LongeCity Media & Archives / Blog entries
November 2020 Longevity Review
Sun Dec 06, 2020 6:39 pm
[background=transparent]In personal news, now that I’ve finally caught up with producing these reviews after falling badly behind a couple of months ago, I’ve started writing a longevity master plan for the next steps going forward. It’s early days, as I’ve given myself until the end of the year, but suffice to say I’m incredibly excited for 2021! Some of my ideas are quite large, such as the creation of a Canadian non-profit, and these will require help. Fortunately, I’ve already got somebody, but will need many more hands on deck - please reach out if you’re interested in getting involved with longevity advocacy. [/background]
[background=transparent]In the meantime - stay safe![/background]
[background=transparent]Follow me on Twitter @ChrisPollyanna1 for the latest updates.[/background]
[background=transparent]Please join my longevity [/background][background=transparent]Facebook group[/background][background=transparent].[/background]
[background=transparent]For those near Toronto, there’s also a [/background][background=transparent]Meetup Group[/background][background=transparent], which will soon be emerging from COVID hibernation.[/background]
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[background=transparent]NOTE: I’ve been having trouble linking to the science journal hacking site [/background][background=transparent]www.sci-hub.se[/background][background=transparent], so am only including Full Text links to articles not behind a paywall. I still have been able to download most of them, so if there are any that you are after, I can send them upon request, or you can simply copy the paper’s URL into the site above to get +95% of papers hidden behind paywalls.[/background]
[background=transparent]Interesting Human Study Results[/background]
[background=transparent]First off, three studies which boosted cognition via either dark chocolate, probiotics or wheat germ:[/background]
[background=transparent]*Cocoa flavanols boost brain oxygenation, cognition in healthy adults[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Randomized Clinical Trial Examining the Impact of Lactobacillus rhamnosus GG Probiotic Supplementation on Cognitive Functioning in Middle-aged and Older Adults[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Now, three studies dealing in heart failure using Astaxanthin, Nicotinamide Riboside (NR), or Resveratrol:[/background]
[background=transparent]*Changes in self-reported physical activity and health-related quality of life following 3-month astaxanthin supplementation in patients with heart failure: results from a pilot study[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Resveratrol Improves Heart Function by Moderating Inflammatory Processes in Patients with Systolic Heart Failure[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background][background=transparent]Leaf Review[/background]
[background=transparent]And finally, an interesting study showing Aspirin use slowing down the ageing of the colon:[/background]
[background=transparent]*Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]November Round-Up:[/background]
[background=transparent]Starting off with a fantastic report from Nature which showcases the depth and breadth of the senolytics field. There are so many shots on goal that surely a few will go in?![/background]
[background=transparent]Send in the senolytics[/background]
[background=transparent]The [/background][background=transparent]Interventions Testing Program[/background][background=transparent] from the NIA has released the latest batch of results, and although they failed to show any life extension for Minocycline, β-guanidinopropionic acid, MitoQ, and 17-DMAG, they furthered our understanding of Rapamycin dosages:[/background]
[background=transparent]Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]While the latest ITP report drew some blanks, this study showed that some in-use diabetes medications lengthened the lives of mice as well as showing reduced mortality in humans.[/background]
[background=transparent]PPARγ agonists delay age-associated metabolic disease and extend longevity[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Here, more evidence for the potential benefits of Alpha-Ketoglutarate supplementation; this time for osteoporosis.[/background]
[background=transparent]Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background][background=transparent]LEAF Review[/background]
[background=transparent]Now, a follow up to a [/background][background=transparent]May study[/background][background=transparent] showing the rejuvenatory effect of diluting plasma in mice, here, improved cognition is shown. [/background]
[background=transparent]Plasma dilution improves cognition and attenuates neuroinflammation in old mice[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background][background=transparent]LEAF Review[/background]
[background=transparent]There’s been a lot of work in trying to create accurate ageing clocks, which would really speed up the search for interventions that work, and here, a number of them have been put to the test with Horvath’s GrimAge Clock coming out the winner.[/background]
[background=transparent]*GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality[/background][background=transparent] [/background][background=transparent]LEAF Review[/background]
[background=transparent]Finally, for longevity treatments to go mainstream, we need our doctors on board. Here is a brand new online course aimed at getting people (especially doctors) up to speed with longevity medicine. The course is not expensive, and they even have free registration days every month. I’ve signed up and will let you know what it’s like.[/background]
[background=transparent]New Course to Teach Doctors About Longevity Medicine[/background][background=transparent] [/background][background=transparent]Longevity Medicine Course[/background]
[background=transparent]Covid-19 Longevity Related Papers:[/background]
[background=transparent]Is there a link between vitamin D status, SARS-CoV-2 infection risk and COVID-19 severity?[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Vitamin D and SARS-CoV-2 infection—evolution of evidence supporting clinical practice and policy development Full Text[/background]
[background=transparent]Can Melatonin Be a Potential "Silver Bullet" in Treating COVID-19 Patients?[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in cultured Vero cells Full Text[/background]
[background=transparent]The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19[/background][background=transparent] [/background][background=transparent]Full Text[/background]
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[background=transparent]Videos to watch: [/background]
[background=transparent]LEAF have launched a separate YouTube channel for their LifeXtenShow, which at the time of writing has 34 episodes about all things Life Extension (see what they did with the name?). Well worth checking out:[/background]
[background=transparent]LifeXtenShow | All episodes[/background]
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[center][background=transparent]2020 Supplemental Information[/background][/center]
[background=transparent]***Disclaimer[/background][background=transparent] [/background][background=transparent]1 [/background][background=transparent]– As should be self-evident to anyone receiving these emails, I am NOT a doctor or indeed a scientist. All the information pertained within is for information purposes only; use at your own risk. Please consult with a healthcare practitioner if needing medical advice.[/background][background=transparent]***[/background]
[background=transparent]**Disclaimer 2 – [/background][background=transparent]In no way should supplements be a replacement for an unhealthy diet or lifestyle. A varied, plant dominant dietary pattern is the cornerstone for health. Try to eat the rainbow – the greater the variety, the greater the benefit. Even though I might take a supplement derived from a plant source, I still eat the plant in question. Also, make sure you move as much as possible – that is what we evolved to do.[/background][background=transparent]**[/background][background=transparent] [/background]
[background=transparent]*[/background][background=transparent]Also bear in mind that most of the studies mentioned below are in rodents, not humans. Rodents, needless to say, do not always react the same way to drugs as humans do – witness the countless times cancer or another disease has been cured in rodents only to subsequently fail human trials. I have [/background][background=transparent]*bolded[/background][background=transparent] any human trials.[/background][background=transparent]*[/background]
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[background=transparent]Lifestyle[/background]
[background=transparent]Fasting/Dietary Restriction[/background][background=transparent] – certainly the cheapest & also one of the most effective anti-ageing interventions currently available. It comes in many flavours, but I fast for at least 12 hours every day. [/background]
[background=transparent]*Effects of consuming later evening meal versus earlier evening meal on weight loss during a Weight Loss Diet: a randomized clinical trial[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Caloric restriction: implications for sarcopenia and potential mechanisms[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Diet – [/background][background=transparent]let food be thy medicine…[/background]
[background=transparent]Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties: A Comprehensive Review to Prolong Human Life[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Nutrients and Pathways that Regulate Health Span and Life Span[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Exercise[/background][background=transparent] – if you could bottle the benefits of exercise, it would be the biggest blockbuster drug of all time.[/background]
[background=transparent]*Aim to exceed weekly recommended physical activity level to offset health harms of prolonged sitting[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Shedding Light on the Effects of Moderate Acute Exercise on Working Memory Performance in Healthy Older Adults: An fNIRS Study[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Non-prescription Supplements (in alphabetical order)[/background]
[background=transparent]*Due to concerns about engendering homeostasis, I’ve begun varying my intake of supplements so that I’m not taking all of them every day. Haven’t worked out a rota so far.[/background]
[background=transparent]Astaxanthin[/background][background=transparent] – which is behind the pink colour of salmon & shrimp. Considered the most powerful carotenoid, it has anti-oxidative, anti-inflammatory, anti-cancer, neuro-protective and skin-protective qualities. I take 4 or 8 mg intermittently.[/background]
[background=transparent]Antioxidant and anti‑inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review)[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions[/background][background=transparent] [/background][background=transparent]Full Text [/background]
[background=transparent]Astaxanthin protects cognitive function of vascular dementia[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Curcumin[/background][background=transparent] – the spice which gives curries their yellow colour. Anti-inflammatory and neuroprotective. I take 1 gram intermittently. Needs to be taken with black pepper (piperine) to improve bioavailability. [/background]
[background=transparent]*Antioxidant Potential of Curcumin-A Meta-Analysis of Randomized Clinical Trials[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Effects of the Use of Curcumin on Ulcerative Colitis and Crohn's Disease: A Systematic Review[/background]
[background=transparent]*The effect of curcumin supplementation on recovery following exercise-induced muscle damage and delayed-onset muscle soreness: A systematic review and meta-analysis of randomized controlled trials[/background]
[background=transparent]Fisetin[/background][background=transparent] – a flavonoid found in highest concentrations in strawberries. Senolytic, anti-inflammatory, anti-cancer, neuro-protective & Sirt1 activator. I take 100mg intermittently. [/background]
[background=transparent]Modulation of the Neuroprotective and Anti-inflammatory Activities of the Flavonol Fisetin by the Transition Metals Iron and Copper[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX-1 in apoE -/- mice[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Melatonin[/background][background=transparent] – a natural hormone produced in the pineal gland, it makes us get to sleep every night, but it has many other functions, including as a mitochondrial antioxidant. I’ve been taking 3mg for years before bed time as a sleep aid.[/background]
[background=transparent]Is Melatonin the Cornucopia of the 21st Century?[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials[/background]
[background=transparent]Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway[/background][background=transparent] [/background][background=transparent] Full Text[/background]
[background=transparent]Nicotinamide MonoNucleotide (NMN)[/background][background=transparent] [/background][background=transparent]– NAD+ precursor. I take 250 – 500mg on days I exercise.[/background]
[background=transparent]CD38-expressing macrophages drive age-related NAD+ decline[/background][background=transparent] [/background][background=transparent]Abstract[/background]
[background=transparent]Nicotinamide Mononucleotide Inhibits Hepatic Stellate Cell Activation to Prevent Liver Fibrosis via Promoting PGE 2 Degradation[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Comparative proteomic analysis identifies biomarkers for renal aging[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Nicotinamide Riboside (NR)[/background][background=transparent] [/background][background=transparent]– NAD+ precursor.[/background]
[background=transparent]Can nicotinamide riboside protect against cognitive impairment?[/background][background=transparent] [/background]
[background=transparent]Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1 G93A Mice[/background]
[background=transparent]Pterostilbene[/background][background=transparent] – found in blueberries. Anti-oxidant, anti-inflammatory and Sir1 activator. Similar to, but with greater bioavailability than resveratrol. Taking 50mg intermittently in the same pill as resveratrol. Works better in conjunction with NAD+ precursors.[/background]
[background=transparent]Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Pterostilbene, A Bioactive Component of Blueberries, Alleviates Renal Interstitial Fibrosis by Inhibiting Macrophage-Myofibroblast Transition[/background]
[background=transparent]Activity of Pterostilbene Metabolites against Liver Steatosis in Cultured Hepatocytes[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Resveratrol[/background][background=transparent] – found in the skin of grapes. Anti-oxidant, anti-inflammatory and Sir1 activator. Taking 250mg intermittently in the same pill as pterostilbene. Works better in conjunction with NAD+ precursors & Spermidine.[/background]
[background=transparent]*Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]The influence of dietary conditions in the effects of resveratrol on hepatic steatosis[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Spermidine[/background][background=transparent] – found in wheat germ and a potent inducer of autophagy, it works in synergy with Resveratrol. I try to eat a few teaspoons of wheat germ every day in my berry & nut breakfast.[/background]
[background=transparent]Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Spermidine ameliorates high-fat diet-induced hepatic steatosis and adipose tissue inflammation in preexisting obese mice[/background]
[background=transparent]Other available supplements (in alphabetical order) [/background]
[background=transparent]Glucosamine may reduce overall death rates as effectively as regular exercise, study suggests[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Legacy Effect of Antioxidant N-acetylcysteine in Cellular Senescence of Diet-induced Obesity Mice[/background]
[background=transparent]Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Quercetin promotes in vitro maturation of oocytes from humans and aged mice[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Protective effects of flavonoids in acute models of light-induced retinal degeneration[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background]
[background=transparent]Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background]
[background=transparent]Prescription Supplements[/background]
[background=transparent]Metformin – [/background][background=transparent]Anti-diabetic medication, maintained by many scientists to be a safe longevity enhancing medication. I’m still on the fence about this.[/background]
[background=transparent]*No effects of dapagliflozin, metformin or exercise on plasma glucagon concentrations in individuals with prediabetes: A post hoc analysis from the randomized controlled PRE-D trial[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Age is decisive for positive or negative effects of the diabetes drug metformin[/background][background=transparent] [/background][background=transparent]Abstract[/background]
[background=transparent]Rapamycin[/background][background=transparent] (sirolimus) – first drug proven to increase the health & lifespan of mice. Currently used for organ transplantation and against cancer. [/background]
[background=transparent]Rapamycin Eyedrops Increased CD4 + Foxp3 + Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Chronic low-dose rapamycin treatment fine tunes cardioprotective signalling in ischaemia-reperfused diabetic hearts[/background][background=transparent] [/background][background=transparent]Abstract[/background]
[background=transparent]Rapamycin Ameliorates Cognitive Impairments and Alzheimer's Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of Streptozotocin-Induced Diabetic Mice[/background]
[background=transparent]Other Areas of Interest (in alphabetical order)[/background]
[background=transparent]Ageing Clocks & other biomarkers of ageing[/background]
[background=transparent]*Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Polygenic risk score of longevity predicts longer survival across an age-continuum[/background][background=transparent]*[/background]
[background=transparent]Epigenetics[/background]
[background=transparent]Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome Full Text[/background]
[background=transparent]Association of Neighborhood Deprivation With Epigenetic Aging Using 4 Clock Metrics[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Exosomes [/background][background=transparent](small packets of information released by cells)[/background]
[background=transparent]Stem Cell-Derived Exosomes and Nanovesicles: Promotion of Cell Proliferation, Migration, and Anti-Senescence for Treatment of Wound Damage and Skin Ageing[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Roles of exosomal miRNA in vascular aging[/background]
[background=transparent]Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys[/background]
[background=transparent]Genetics[/background]
[background=transparent]DNA Damage and Mitochondria in Cancer and Aging[/background][background=transparent] [/background][background=transparent] Full Text[/background]
[background=transparent]Rare gene mutation hints at 'fountain of youth'[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background]
[background=transparent]Identifying longevity associated genes by integrating gene expression and curated annotations[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Lifespan Lengthening Interventions[/background]
[background=transparent]Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Inhibition of PAR-1 delays aging via activating AMPK in C. elegans[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Control of lifespan and survival by Drosophila NF-κB signaling through neuroendocrine cells and neuroblasts[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism[/background][background=transparent] [/background]
[background=transparent]Clove essential oil confers antioxidant activity and lifespan extension in C. elegans via the DAF-16/FOXO transcription factor[/background]
[background=transparent]Longevity effects of hispidol in Caenorhabditis elegans[/background]
[background=transparent]Extension of life span and stress tolerance modulated by DAF-16 in Caenorhabditis elegans under the treatment of Moringa oleifera extract[/background]
[background=transparent]SUMO wrestles with mitophagy to extend lifespan[/background]
[background=transparent]Sestrin makes fruit flies live longer[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Microbiome[/background]
[background=transparent]*Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*Vitamin D metabolites and the gut microbiome in older men[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]What connection is there between intestinal microbiota and heart disease?[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Miscellaneous Molecules[/background]
[background=transparent]The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits[/background][background=transparent] [/background][background=transparent]Full Text[/background][background=transparent] [/background]
[background=transparent]Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Senolytics & Senescent Cells [/background]
[background=transparent]Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages[/background][background=transparent] [/background][background=transparent]LEAF Review[/background]
[background=transparent]On the evolution of cellular senescence[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Targeting cellular senescence based on inter-organelle communication, multi-level proteostasis and metabolic control[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Stem Cells [/background]
[background=transparent]Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Human mesenchymal stem cells treatment improved hepatic lesions and reversed gut microbiome disorder in non-alcoholic steatohepatitis[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Telomeres[/background]
[background=transparent]*Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson's disease associated with enhanced autophagy[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Young Blood Factors or other heterochronic transplantations[/background]
[background=transparent]Circulating plasma factors involved in rejuvenation[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Senescent cell accumulation mechanisms inferred from parabiosis[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Odds & Sods[/background]
[background=transparent]*The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review[/background][color=rgb(0,0,0
Read-only archive. Access follows the preserved publication rules; unavailable historical files are marked where applicable.