LongeCity Media & Archives / Blog entries
July 2021 Longevity Review
Fri Aug 13, 2021 7:15 pm
[background=transparent]The big news from me last month was that I overtook the updating of lifespan.io’s [/background][background=transparent]Rejuvenation Roadmap[/background][background=transparent], which charts the progress in developing longevity treatments. Take a look if you want to be heartened by how many companies are working on longevity and how close some treatments are to becoming commercially available.[/background]
[background=transparent]For further glimpses of progress, next week (19-22 August), Lifespan.io will be hosting their annual conference, [/background][background=transparent]Ending Age Related Diseases 2021[/background][background=transparent], virtually again. The [/background][background=transparent]program[/background][background=transparent] once more features a stellar lineup of the leading researchers in the field. If you want to hear about the latest breaking results before they’ve even had the chance to be published, then this is the place to be. Even better, you can grab yourself [/background][background=transparent]a free ticket[/background][background=transparent] to see the 4 keynote speakers. I will again be volunteering behind the scenes.[/background]
[background=transparent]Now that in Toronto at least most people are fully vaccinated, I’m bringing my [/background][background=transparent]longevity Meetup group[/background][background=transparent] out of hibernation - I’m very much looking forward to finally seeing people in person again, and meeting some people for the first time. If you are [/background][background=transparent]free on Sunday evening[/background][background=transparent], please feel free to join us![/background]
[background=transparent] [/background]
[background=transparent]Follow me on Twitter @ChrisPollyanna1 for the latest updates.[/background]
[background=transparent]For previous updates, you can find them in the [/background][background=transparent]Canadian Longevity Association[/background][background=transparent] Facebook group, and also my [/background][background=transparent]Patreon account[/background][background=transparent], which includes bonus material for members.[/background]
[background=transparent]Finally, if you are interested in helping me create a Canadian longevity non-profit, then please contact me via the [/background][background=transparent]Canadian Longevity Association website[/background][background=transparent].[/background]
[background=transparent]---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------[/background]
[background=transparent]Round-Up:[/background]
[background=transparent]As regular readers are well aware, [/background][background=transparent]senolytics[/background][background=transparent] hold great promise, but can that promise translate to humans? Here we have the first results from Unity’s second senolytic, this time for diabetic macular edema and wet age-related macular degeneration. Their first drug failed in Phase 2, so we have our fingers crossed that their second drug is more successful.[/background]
[background=transparent]*Senolytics Show Positive Results in Phase 1 Clinical Trial[/background][background=transparent] [/background][background=transparent]Press Release[/background]
[background=transparent]Not as powerful as senolytics, Nicotinamide Mononucleotide also shows promise based on animal data, but before this year there had been limited data in humans. Here we have the second human study to be released this year, once again showing some benefit, though perhaps not as great as we had hoped for. [/background]
[background=transparent]*NMN Enhances Aerobic Capacity in Amateur Runners[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]The importance of our microbiome has increasingly become apparent, opening up opportunities for its modulation to improve our health. Here are a couple examples from the last month showing improvements in functional performance for the frail and metabolic biomarkers in the obese. [/background]
[background=transparent]*Lactobacillus plantarum TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial Full Text[/background]
[background=transparent]*Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial Full Text[/background]
[background=transparent]Here, researchers have created stem cells which have been engineered to evade our immune system, thereby greatly extending their potential, as immune rejection was one of the limiting factors for their long-term use.[/background]
[background=transparent]Engineered cells successfully treat cardiovascular and pulmonary disease[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Covid-19 Longevity Related Papers:[/background]
[background=transparent]Targeting aging cells improves survival Full Text[/background]
[background=transparent]*Therapeutic prevention of COVID-19 in elderly: a case–control study Full Text[/background]
[background=transparent]*The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus Full Text[/background]
[background=transparent]---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------[/background]
[background=transparent]Podcast to listen to: [/background]
[background=transparent]Following on from my work on the Rejuvenation Roadmap, if you’re interested in finding out more about the biotech side of longevity, then my friend and fellow Torontonian’s podcast is well worth checking out. The Longevity Biotech Show features in depth interviews with the founders and leading lights from biotechs interested in longevity.[/background]
[background=transparent]The Longevity Biotech Show[/background]
[background=transparent]==========================================================================================================================================[/background]
[center][background=transparent] 2021 Supplemental Information[/background][/center]
[background=transparent]***Disclaimer[/background][background=transparent] [/background][background=transparent]1 [/background][background=transparent]– As should be self-evident to anyone receiving these emails, I am NOT a doctor or indeed a scientist. All the information pertained within is for information purposes only; use at your own risk. Please consult with a healthcare practitioner if needing medical advice.[/background][background=transparent]***[/background]
[background=transparent]**Disclaimer 2 – [/background][background=transparent]In no way should supplements be a replacement for an unhealthy diet or lifestyle. A varied, plant dominant dietary pattern is the cornerstone for health. Try to eat the rainbow – the greater the variety, the greater the benefit. Even though I might take a supplement derived from a plant source, I still eat the plant in question. Also, make sure you move as much as possible – that is what we evolved to do.[/background][background=transparent]**[/background][background=transparent] [/background]
[background=transparent]*[/background][background=transparent]Also bear in mind that most of the studies mentioned below are in rodents, not humans. Rodents, needless to say, do not always react the same way to drugs as humans do – witness the countless times cancer or another disease has been cured in rodents only to subsequently fail human trials. I have [/background][background=transparent]*bolded[/background][background=transparent] any human trials.[/background][background=transparent]*[/background]
[background=transparent]---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------[/background]
[background=transparent]Lifestyle[/background]
[background=transparent]Fasting/Dietary Restriction[/background][background=transparent] – certainly the cheapest & also one of the most effective anti-ageing interventions currently available. It comes in many flavours, but I fast for at least 12 hours every day. [/background]
[background=transparent]Fasting: How to Guide Full Text[/background]
[background=transparent]Dietary Restriction for Kidney Protection: Decline in Nephroprotective Mechanisms During Aging Full Text[/background]
[background=transparent]Effects of fasting on skeletal muscles and body fat of adult and old C57BL/6J mice[/background]
[background=transparent]Diet – [/background][background=transparent]let food be thy medicine…[/background]
[background=transparent]*Higher levels of omega-3 acids in the blood increases life expectancy by almost five years[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]*A fermented-food diet increases microbiome diversity and lowers inflammation, study finds[/background][background=transparent] [/background][background=transparent]Abstract[/background]
[background=transparent]*Eating whole grains linked to smaller increases in waist size, blood pressure, blood sugar[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Exercise[/background][background=transparent] – if you could bottle the benefits of exercise, it would be the biggest blockbuster drug of all time.[/background]
[background=transparent]*Six weeks of high intensity cycle training reduces H2O2 emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes Full Text[/background]
[background=transparent]*High-Intensity Interval Training in Older Adults: a Scoping Review Full Text[/background]
[background=transparent]*Regular Strength and Sprint Training Counteracts Bone Aging: A 10-Year Follow-Up in Male Masters Athletes Full Text[/background]
[background=transparent]Non-prescription Supplements (in alphabetical order)[/background]
[background=transparent]*Due to concerns about engendering homeostasis, I’ve begun varying my intake of supplements so that I’m not taking all of them every day. Haven’t worked out a rota so far.[/background]
[background=transparent]Astaxanthin[/background][background=transparent] – which is behind the pink colour of salmon & shrimp. Considered the most powerful carotenoid, it has anti-oxidative, anti-inflammatory, anti-cancer, neuro-protective and skin-protective qualities. I take 4 or 8 mg intermittently.[/background]
[background=transparent]Mitochondrion as a Target of Astaxanthin Therapy in Heart Failure Full Text[/background]
[background=transparent]Astaxanthin Protects Human Granulosa Cells against Oxidative Stress through Activation of NRF2/ARE Pathway and Its Downstream Phase II Enzymes Full Text[/background]
[background=transparent]Ameliorative effects of astaxanthin against copper(II) ion-induced alteration of pentose phosphate pathway and antioxidant system enzymes in rats[/background]
[background=transparent]Curcumin[/background][background=transparent] – the spice which gives curries their yellow colour. Anti-inflammatory and neuroprotective. I take 1 gram intermittently. Needs to be taken with black pepper (piperine) to improve bioavailability. [/background]
[background=transparent]Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling Full Text[/background]
[background=transparent]Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review Full Text[/background]
[background=transparent]Is Curcumin the Answer to Future Chemotherapy Cocktail? Full Text[/background]
[background=transparent]Fisetin[/background][background=transparent] – a flavonoid found in highest concentrations in strawberries. Senolytic, anti-inflammatory, anti-cancer, neuro-protective & Sirt1 activator. I take 100mg intermittently.[/background]
[background=transparent]Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis Full Text[/background]
[background=transparent]Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation, inhibiting osteoporosis[/background]
[background=transparent]Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome[/background]
[background=transparent]Melatonin[/background][background=transparent] – a natural hormone produced in the pineal gland, it makes us get to sleep every night, but it has many other functions, including as a mitochondrial antioxidant. I take 3mg every night primarily as a sleep aid.[/background]
[background=transparent]Research progress of melatonin (MT) in improving ovarian function: a review of the current status Full Text[/background]
[background=transparent]Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease Full Text[/background]
[background=transparent]The mechanism of oral melatonin ameliorates intestinal and adipose lipid dysmetabolism through reducing Escherichia coli-derived lipopolysaccharide Full Text[/background]
[background=transparent]Nicotinamide MonoNucleotide (NMN)[/background][background=transparent] [/background][background=transparent]– NAD+ precursor. I take 250 – 500mg on days I exercise.[/background]
[background=transparent]Nicotinamide Mononucleotide Combined With Lactobacillus fermentum TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway Full Text[/background][background=transparent] [/background]
[background=transparent]*NAD+ metabolism and cardiometabolic health: the human evidence Full Text[/background]
[background=transparent]Pterostilbene[/background][background=transparent] – found in blueberries. Anti-oxidant, anti-inflammatory and Sir1 activator. Similar to, but with greater bioavailability than resveratrol. Taking 50mg intermittently in the same pill as resveratrol. Works better in conjunction with NAD+ precursors.[/background]
[background=transparent]Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2 Full Text[/background]
[background=transparent]Resveratrol[/background][background=transparent] – found in the skin of grapes. Anti-oxidant, anti-inflammatory and Sir1 activator. Taking 250mg intermittently in the same pill as pterostilbene. Works better in conjunction with NAD+ precursors & Spermidine.[/background]
[background=transparent]Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases Full Text[/background]
[background=transparent]Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging Full Text[/background]
[background=transparent]*Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials[/background]
[background=transparent]Spermidine[/background][background=transparent] – found in wheat germ and a potent inducer of autophagy, it works in synergy with Resveratrol. I try to eat a few teaspoons of wheat germ every day in my berry & nut breakfast.[/background]
[background=transparent]The metabolic role of spermidine in obesity: Evidence from cells to community[/background]
[background=transparent]Other available supplements or natural substances (in alphabetical order) [/background]
[background=transparent]Astragaloside IV prevents memory impairment in D-galactose-induced aging rats via the AGEs/RAGE/ NF-κB axis Full Text[/background]
[background=transparent]*Impact of β-hydroxy-β-methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT [/background][background=transparent] [/background]
[background=transparent]*Effect of Carnosine or β-Alanine Supplementation on Markers of Glycemic Control and Insulin Resistance in Humans and Animals: A Systematic Review and Meta-analysis Full Text[/background]
[background=transparent]Matricaria chamomilla (Chamomile) Ameliorates Muscle Atrophy in Mice by Targeting Protein Catalytic Pathways, Myogenesis, and Mitochondrial Dysfunction[/background]
[background=transparent]Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro[/background]
[background=transparent]Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway Full Text[/background]
[background=transparent]Grape skin extract modulates neuronal stem cell proliferation and improves spatial learning in senescence-accelerated prone 8 mice Full Text[/background]
[background=transparent]*Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients Full Text[/background]
[background=transparent]*Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study Full Text[/background]
[background=transparent]Combinations of Supplements[/background]
[background=transparent]*Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study Full Text[/background]
[background=transparent]*Effectiveness of Tinnitan Duo® in Subjective Tinnitus with Emotional Affectation: A Prospective, Interventional Study Full Text[/background]
[background=transparent]Protective effects of Quercetin and Resveratrol on aging markers in kidney under high glucose condition: in vivo and in vitro analysis[/background]
[background=transparent]Prescription Supplements[/background]
[background=transparent]Metformin[/background][background=transparent] – [/background][background=transparent]Anti-diabetic medication, maintained by many scientists to be a safe longevity enhancing medication. [/background]
[background=transparent]*A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach Full Text[/background]
[background=transparent]*Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects Full Text[/background]
[background=transparent]Rapamycin[/background][background=transparent] (sirolimus) – first drug proven to increase the health & lifespan of mice. Currently used for organ transplantation and against cancer. [/background]
[background=transparent]The inhibition of mammalian target of rapamycin (mTOR) in improving inflammatory response after traumatic brain injury Full Text[/background]
[background=transparent]Inhibition of mTOR signaling by rapamycin protects photoreceptors from degeneration in rd1 mice Full Text[/background]
[background=transparent]Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration Full Text[/background]
[background=transparent]Miscellaneous Molecules[/background]
[background=transparent]17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy[/background]
[background=transparent]Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity Full Text[/background]
[background=transparent]SGLT2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body-induced NRF2 activation[/background]
[background=transparent]Other Areas of Interest (in alphabetical order)[/background]
[background=transparent]Ageing Clocks & other biomarkers of ageing [/background]
[background=transparent]*‘Inflammation clock’ can reveal body’s biological age Full Text[/background][background=transparent] [/background][background=transparent]Abstract[/background]
[background=transparent]The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets[/background]
[background=transparent]*The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study[/background]
[background=transparent]Blood Factors or other Heterochronic Transplantation [/background]
[background=transparent]Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach Full Text[/background]
[background=transparent]Emerging insights into the role of albumin with plasma exchange in Alzheimer’s disease management Full Text[/background]
[background=transparent]Exposure to Plasma From Non-alcoholic Fatty Liver Disease Patients Affects Hepatocyte Viability, Generates Mitochondrial Dysfunction, and Modulates Pathways Involved in Fat Accumulation and Inflammation Full Text[/background]
[background=transparent]Epigenetics & Cellular Reprogramming[/background]
[background=transparent]*Ageing-associated changes in DNA methylation in X and Y chromosomes Full Text[/background]
[background=transparent]Early-life social experience affects offspring DNA methylation and later life stress phenotype Full Text[/background]
[background=transparent]*Epigenetic regulation of energy metabolism in obesity Full Text[/background]
[background=transparent]Exosomes [/background][background=transparent](small packets of information released by cells)[/background]
[background=transparent]Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo Full Text[/background]
[background=transparent]Extracellular vesicles in the treatment of neurological disorders Full Text[/background]
[background=transparent]The Emerging Role of Exosomes in the Treatment of Human Disorders With a Special Focus on Mesenchymal Stem Cells-Derived Exosomes Full Text[/background]
[background=transparent]Genetics including CRISPR[/background]
[background=transparent]*Genetic signature of human longevity in PKC and NF-κB signaling Full Text[/background]
[background=transparent]Lifespan-Associated Gene Expression Signatures of Recombinant BXD Mice Implicates Coro7 and Set in Longevity Full Text[/background]
[background=transparent]Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast Full Text[/background]
[background=transparent]Lifespan Lengthening Interventions [/background]
[background=transparent]Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity Full Text[/background]
[background=transparent]AI built to find anti-aging chemical compounds[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Skeletal Muscle Specific Calpastatin Overexpression Mitigates Muscle Weakness in Aging and Extends Lifespan[/background]
[background=transparent]Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span[/background]
[background=transparent]Microbiome[/background][background=transparent] [/background]
[background=transparent]Common features of aging fail to occur in Drosophila raised without a bacterial microbiome Full Text[/background]
[background=transparent]The Relationship Between the Gut Microbiome and Neurodegenerative Diseases Full Text[/background]
[background=transparent]*The Roles of the Gut Microbiota and Chronic Low-Grade Inflammation in Older Adults With Frailty Full Text[/background]
[background=transparent]Observational Studies[/background]
[background=transparent]*Compassion toward others and self-compassion predict mental and physical well-being: a 5-year longitudinal study of 1090 community-dwelling adults across the lifespan Full Text[/background]
[background=transparent]*Stratification in health and survival after age 100: evidence from Danish centenarians Full Text[/background]
[background=transparent]*Increasingly capable at the ripe old age? Cognitive abilities from 2004 to 2013 in Germany, Spain, and Sweden Full Text[/background]
[background=transparent]Opinion/Editorials/Theory[/background]
[background=transparent]Toward the development of a vibrant, super-aged society:The future of medicine and society in Japan Full Text[/background]
[background=transparent]The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm[/background]
[background=transparent]Senescence: why and where selection gradients might not decline with age Full Text[/background]
[background=transparent]Other Ageing Biology[/background]
[background=transparent]Protein pile-up plays havoc in ageing nematode worms[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Manipulating the exposome to enable better ageing Full Text[/background]
[background=transparent]Emerging Therapeutic Potential of SIRT6 Modulators Full Text[/background]
[background=transparent]Scientists reverse age-related memory loss in mice[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]Reviews[/background]
[background=transparent]Cardiac regeneration by direct reprogramming in this decade and beyond Full Text[/background]
[background=transparent]mTORC2: The other mTOR in autophagy regulation Full Text[/background]
[background=transparent]*Sex differences in frailty: Comparisons between humans and preclinical models Full Text[/background]
[background=transparent]Senolytics/Senescent Cells [/background]
[background=transparent]Senolytics Improve Spinal Cord Recovery in Mice[/background][background=transparent] [/background][background=transparent]Full Text[/background]
[background=transparent]LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells Full Text[/background]
[background=transparent]Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls Full Text[/background]
[background=transparent]Skin & Beauty [/background]
[background=transparent]Red ginseng oil promotes hair growth and protects skin against UVC radiation Full Text[/background]
[background=transparent]Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway[/background]
[background=transparent]*Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals Full Text[/background]
[background=transparent]*Effects of a Combination of Botanical Actives on Skin Health and Antioxidant Status in Post-menopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial[/background]
[background=transparent]Stem Cells [/background]
[background=transparent]Mesenchymal stem cells: ideal seeds for treating diseases Full Text[/background]
[background=transparent]Stem Cell Ovaries Now Functional in Mice[/background][background=transparent] [/background][background=transparent]Abstract[/background]
[background=transparent]Mesenchymal Stem Cells in Treatment of Spinal Cord Injury and Amyotrophic Lateral Sclerosis Full Text[/background]
[background=transparent]Telomeres[/background][background=transparent] [/background]
[background=transparent]*Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity?[/background]
[background=transparent]*Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers Full Text[/background]
[background=transparent]*Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis[/background]
[background=transparent]Odds & Sods[/background]
[background=transparent]*Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men Full Text[/background]
[background=transparent]*Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia Full Text[/background]
[background=transparent]*Can Transcranial Direct Current Stimulation Enhance Functionality in Older Adults? A Systematic Review Full Text[/background]
[background=transparent]*Acupuncture-Related Therapies for Parkinson's Disease: A Meta-Analysis and Qualitative Review Full Text[/background]
[background=transparent]*Preferred life expectancy and the association with hypothetical adverse life scenarios among Norwegians aged 60+ Full Text[/background]
[background=transparent]Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci Full Text[/background]
Read-only archive. Access follows the preserved publication rules; unavailable historical files are marked where applicable.