"In 2006, researchers had reported that mice lacking SIRT6 seemed to age more quickly[sup]2[/sup]. The mice were small and sickly, had a reduced capacity to repair damaged DNA, and died a month after birth.
Cohen and his colleagues decided to find out what would happen if mice expressed higher levels of the SIRT6 protein than normal. They found that longevity in female mice was unaffected by the excess protein, but that the median lifespan of male mice rose by 14.5% in one line of their transgenic mice and 9.9% in another."
