LongeCity - My Stack (good for vegetarians/OCD personalities)

Category: Life Extension, General Health
Anti-aging/mental optimization/general health
Ingredients:
- raloxifene — 60 mg, Daily
- dutasteride — 0.5 mg, Twice a week
- deprenyl — 5mg mg, Daily
- Black Cumin Seed Oil — ~2 ml, Daily
- MCT oil — ~5 ml, Daily
- Olive Oil — ~5 ml, Daily
- Turmeric — 1/2 teaspoon, Daily
- Black Pepper — 1/8 teaspoon, Daily
- Ashwangandha — 1/3 teaspoon, Daily
- Dried Parsely (apigenin) — 1 teaspoon, Daily
- Bacopa — 1/3 teaspoon, Daily
- Green Lipped Mussle — 1 pill(s), Daily
- ALCAR — 500 mg, Daily
- Carnosine — 500 mg, Daily
- NAC — 600 mg, Daily
- Lithium Orotate — 5 mg, Daily
- PQQ — 20 mg, Twice a week
- Glycine — 3-5 gram, Daily
- Methyl B12 — 1 mg, Daily
- Ubiquinol — 100 mg, Twice a week
- Melatonin — 300 µg, Daily
This is my stack, with a few different focuses (note that their are overlaps between categories): -Anti aging, though I am still fairly young and fairly broke so I'm more conservative and prefer supplements which have proven to extend lifespan in mammals. This includes: deprenyl, raloxifene, turmeric/black pepper, Ashwangandha , Bacopa, Apigenin (dried parsley), NAC, low-dose lithium, PQQ, ubiquinol. -Nutrients lacking in vegetarian diet: B12, glycine, carnosine, ALCAR, green lipped mussel (DHA, EPA and glucosamine/chondroitin). -Nutrients good for OCD/bipolar types (I have generally very good mental health but lean to this side of the spectrum): NAC, low dose lithium, melatonin. -Anti inflammatory (also generally helpful for brain function): Turmeric/black pepper, Black cumin seed oil, NAC, probably most others to some extent. -General cognitive function: Panex Ginseng, deprenyl, black tea, green tea. I have refined it according to what works well for me. About me: -26 year old male -Neuroscience PhD student -High level of exercise* (aerobic running/biking, bouldering, weight lifting, various forms of yoga). Generally in good shape, raced a half ironman last year (probably lost a year off my life with that one). -Vegetarian diet (not vegan), average 14-16 hour daily fast (I skip breakfast), high vegetable intake, I try to not eat much carbs except in a window a few hours around dinner, avoid most sugar.* -Daily brief meditation practice*, prioritize spiritual life, consciously avoid stressful or distracting media. -Personality: Generally relaxed, introverted but often social, low stress, optimistic, sometimes leaning to the hypomanic/OCD spectrum if I don't watch my mental/physical health. -I have several mutations according to my 23andme results which influence this regimen. These include: TNF-alpha (increased function SNP), glycine transporter mutation (reduced glycine uptake), homozygous SOD2 mutation (reduced SOD2 activity, justifies more mitochondrial antioxidants in my mind), homozygous MTHFR (folate receptor mutation; can result in increased homocysteine), many DRD2 dopamine receptor SNP's, 1 APOE epsilon4 allele (slightly increased alzheimers risk). This may seem like a lot but I don't worry too much; even the homozygous combos are not uncommon in the healthy population. *exercise, diet and mindfulness training are easily more important than all the supplements in this stack combined. Specific experiences: -NAC: improved mental clarity, relaxation and slight tiredness. Reduced intestinal inflammation/muscle soreness. -low dose lithium: improved mental evenness. -tea, ginseng: enhanced focus, good for working. -melatonin: Slightly better sleep, more daytime wakefulness. -raloxifene: Somewhat reduced anxiety and improved general mindfulness (may be placebo). -The rest I think are cumulatively very beneficial but I don't feel confident that I actively notice anything more than a placebo effect. Specific reasons for some things: -raloxifene I haven't seen much on here, but it is a mostly side effect free. non-feminizing SERM with nothing but positive effects on a variety of physiological functions in men and women, and I'm hoping it helps me close the gender lifespan gap. -deprenyl, along with being one of the best life extension compounds known for awhile, also enhances dopamine function in a way which is beneficial given my poor DRD2 genotype. Also, I have a family history of Parkinson's. -dutasteride: I don't want to lose my hair or get prostate cancer, and DHT seems to mediate a lot of the negative effects of testosterone including fibrosis from papers I've read. Plus, I don't get side effects on the relatively low dose. -apigenin: As a CD38 inhibitor it may have more of an effect on NAD+ levels than NR (and is much cheaper). -I try to take things in the least processed version sensible (dried parsley for apigenin, for example). Everything I take adds up to less than $800 per year (less than $2.50 per day). Some things which have not worked well for me: -low-dose aspirin: Bad stomach problems. -BCAA's: Kidney pain -Myoinisitol: Increased manic thoughts for a few hours. -Hi-Maize: Lots of flatulence. Some things which I would take at 40 pending further good safety and efficacy results/availability: -weekly rapamycin or rapalogue -Nicotinamide Riboside -pterostilbene -Epitalon -SKQ1 -C60 -SS-31 -MK677 -Whichever senescent cell removal treatment proves itself best in the next 10 years. -Sam-E if I have high homocysteine levels (based off of MTHFR mutation). -Some cardiovascular polypill if my doctor recommended it, but I doubt it given that I eat well/ excercise. Please, input much appreciated, or PM me if curious about something. I'm not 100% sure if I should be taking these with more food. Some references: -Check selfhacked article with references for most supplements here. -Raloxifene: -brain: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC149792/ -prostate cancer: https://www.ncbi.nlm.nih.gov/pubmed/12097269 -cardiovascular (disputed): https://www.ncbi.nlm.nih.gov/pubmed/11314601 -skin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685269/ -bones: http://www.webmd.com/osteoporosis/guide/serms -don't take raloxifene if you have blood clotting/DVT issues. -dutasteride: -hair loss: https://www.ncbi.nlm.nih.gov/pubmed/24411083 -prostate cancer: http://www.nejm.org/doi/full/10.1056/NEJMoa0908127#t=article (can reduce detection of early grade tumors via PSA screening though). -all cause mortality: https://www.ncbi.nlm.nih.gov/pubmed/24628549 -relaxin/flexibility: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975417/ -DHT has positive effects too, so I take a low dose. Finasteride is a less powerful alternative.
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Rating: 3 (2 votes) — Views: 6286

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Aardvark202 — 2017-05-20 15:56:50 UTC

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