LongeCity Media & Archives / Regimens

Mithocondrial function

Fri Jun 09, 2017 8:32 am

Category: Medical
Treat mithocondrial dysfunction
Ingredients:
- Melatonin — 1-10 mg, Daily
- CoQ10 — 100 mg, Daily
- Vitamin C — 2-3 gram, Daily
- Glutathione (Reduced) — 500 mg, Daily
- Magnesium — 200 mg, Daily
- Turmeric — 500 mg, Daily
This is my bedtime stack to treat my mitochondrial dysfunction due to a genetic condition. After years trying to increase my ATP output, I find that I get better results by minimizing the systemic effects of the decreased ATP production. Notes:
  • It is important to take this at bedtime. I have tried the very same stack (minus melatonin) in the morning, but it does work not for me.
  • For best results, titrate the melatonin dosage. Start with 1mg and increase it by 1mg every 2-3 days until you wake up groggy. At this point, return to the last "working" dosage.
  • Note that you may need to adjust the melatonin dosage based on workout/non-workout days. I find that I need 1/3 of the dosage (1mg vs3mg) in non-workout days.
  • Melatonin + CoQ10 + Vitamin C + Turmeric is the basic stack. In my case, Glutathione and Magnesium give only marginal benefits.
  • I use Meriva for Turmeric. If you take plain old turmeric, you may need to increase the dosage significantly (and add some piperine to improve bio-availability)
This basic stack has improved my quality of life significantly. In retrospect, I find it funny all the crazy things I have tried over the years. A partial list:
  • C60 (a couple of months; no noticeable difference)
  • Methylene blue (I still remember the dizziness I got from this)
  • Low-dose DNP. I still see great potential in uncoupling the electron transport chain to treat my condition, but this one is pretty dangerous (very narrow therapeutic index)
  • Low-dose Modafinil. Great to maintain my energy levels, but at the end, it is a crash and burn for me.
  • NADH. Great for immediate energy, but it builds tolerance pretty fast. Still take it, maybe once a month.
  • All types of adaptogens (Rhodiola, Gingseng, etc). They somehow work, but not like this stack
--------------------
Rating: 3 (2 votes) — Views: 4126

--------------------
Cloomis — 2022-01-04 23:59:10 UTC
Interesting. Wasn't aware of those supplements affecting mitochondria. Do you do exercise targeted at mitochondria health as well?

Read-only archive. Access follows the preserved publication rules; unavailable historical files are marked where applicable.