Category:Medical Ingredients:
- Ubiquinol CoQ10 — 100 mg, twice daily
- PQQ Pyrroloquinoline Quinone (BioPQQ) — 10-15 mg, every other day
- Omega-3 DHA + EPA (3:2) — 350-550 mg, twice daily
- N-Acetyl Cysteine (NAC) — 900 mg, every other day
- Acetyl Carnitine (ALCAR) — 500 mg, Daily
- CDP Choline (citicoline) — 300 mg, Daily
- Solid Lipid Curcumin — 400 mg, Daily
- Phosphatidylserine (PS) — 100 mg, Daily
- EGCG (green tea catechins) — 250 mg, every other day
- L-Theanine (black & green tea) — 100 mg, every other day
- Milk Thistle (silymarin) — 250 mg, every other day
- Vitamin B12 Methylcobalamin — 25 µg, Daily
- Folate (L-methylfolate) — 400 µg, Daily
- Vitamin D3 (Cholecalciferol) — 1000 IU, Daily
- Nobiletin & Tangeretin (citrus flavonoids) — 100 mg, every other day
- Blueberry Extract (anthocyanins) — 500 mg, Daily
- Lipoic Acid — 50-100 mg, Daily
- Bacopa monnieri (50% bacosides) — 300 mg, Daily
- Taurine — 500 mg, every other day
- Olive Oil Fruit & Leaf (Oleuropein) Extract — 500-1000 mg, Daily
- Raw Fruits & Vegetables — 5 serving(s), Daily
- Nicotinamide Riboside (NR) Niagen — 125-250 mg, every other day
- Vitamin C with Citrus Bioflavonoids — 500 mg, every other day
- Apigenin (bioflavonoid) — 50-100 mg, every other day
- Fisetin (flavonoid) — 50-100 mg, every other day
- Probiotic complex — 1 pill(s), Daily
- Magnesium L-threonate — 48 mg, Daily
Important Note: This is my personal stack and positive results are based on personal experience and current studies. It is not intended nor suggests to cure, treat or prevent any disease or medical condition. Actual supplementation and dosage differ based on each individual's needs, tolerance, clinical condition and current medication. Patients should consult their healthcare specialist before initiating any supplementation. Suggested ways to minimize possible adverse effects of supplementation and avoid possible interaction are: [indent=1]a) start with a lower dose and then gradually increase[/indent] [indent=1]b) gradually add more supplements through time and observe for possible interactions[/indent] [indent=1]c) take one week off every 4 weeks OR begin with a medium to full dose supplementation for a period of 1-2 months and then continue with a lower maintenance dose every other day[/indent] [indent=1]d) take with food when possible to minimize gastrointestinal side effects[/indent] [indent=1]e) not recommended long-term high-dose supplementation as the safety profile of many supplements is limited to short-term studies[/indent] [indent=1]f) preferebly choose natural over synthetic versions[/indent] [indent=1]g) add probiotics in diet to boost immunity and maintain healthy gut[/indent] The purpose of this stack is to possibly:
offer overall antioxidant protection. ( Ubiquinol Q10, PQQ, NAC, Flavonoids, Anthocyanins, Lipoic Acid, EGCG, Vitamin C with bioflavonoids )
lower homocystein levels ( Folate, B12, NAC )
Improve mitochondria function & energy ( Nicotinamide Riboside, PQQ, Ubiquinol Q10, NAC, Taurine, Acetyl-Carnitine, Omega-3, Phosphatidylserine )
Recommended Physical Exercise to improve balance and motor control : Tai Chi & Qigong Tai Chi and Postural Stability in Patients with Parkinson's Disease (N Engl J Med, 2012) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285459/ Effects of Tai Chi on balance and fall prevention in Parkinson's disease: a randomized controlled trial. (Clin Rehabil. 2014 ) https://www.ncbi.nlm.nih.gov/pubmed/24519923 A Meta-Analysis on the Efficacy of Tai Chi in Patients with Parkinson's Disease between 2008 and 2014 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306407/ Effects of Health Qigong Exercises on Relieving Symptoms of Parkinson's Disease.(2016) https://www.ncbi.nlm.nih.gov/pubmed/27891159 References: 1) Ubiquinol CoQ10 Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease. (Parkinsonism Relat Disord. 2015 ) https://www.ncbi.nlm.nih.gov/pubmed/26054881 Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum (Barca E1, Kleiner G1, 2016) https://www.ncbi.nlm.nih.gov/pubmed/27235405 2) PQQ Pyrroloquinoline Quinone (BioPQQ) Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions (Adv Exp Med Biol., 2016) https://www.ncbi.nlm.nih.gov/pubmed/26782228 Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease (Neuropharmacology, 2016) https://www.ncbi.nlm.nih.gov/pubmed/27108097 Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804159/ 3) Acetyl Carnitine + Lipoic Acid Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. (J Cell Mol Med., 2010) https://www.ncbi.nlm.nih.gov/pubmed/20414966 4) NAC (N-acetyl-cysteine ) Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice (PLoS One. 2010) https://www.ncbi.nlm.nih.gov/pubmed/20808797 N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. (Clin Neuropharmacol. 2013) https://www.ncbi.nlm.nih.gov/pubmed/21587143 5) Omega 3 Fatty Acids Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase. (Nutr Neurosci, 2017) https://www.ncbi.nlm.nih.gov/pubmed/28221817 Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA (Front Aging Neurosci. 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404917/ 6) Green Tea (EGCG) Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties (Genes Nutr. 2009) www.ncbi.nlm.nih.gov/pmc/articles/PMC2775893/ 7) Anthocyanins Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease. (Brain Res. 2014) https://www.ncbi.nlm.nih.gov/pubmed/24502982 8) Citicoline (CDP-Choline) Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. (Rev Neurol Dis. 2008) https://www.ncbi.nlm.nih.gov/pubmed/19122569 Citicoline in the treatment of Parkinson's disease. https://www.ncbi.nlm.nih.gov/pubmed/2289218 9) Solid Lipid Curcumin Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. (J Med Food. 2015) https://www.ncbi.nlm.nih.gov/pubmed/25490740 10) Taurine Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment. https://www.ncbi.nlm.nih.gov/pubmed/26004911 Mechanism of neuroprotective function of taurine. (Adv Exp Med Biol, 2009) https://www.ncbi.nlm.nih.gov/pubmed/19239147 11) Folate, B12 Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study. (Zhang S1, 2015) https://www.ncbi.nlm.nih.gov/pubmed/26291976 Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. https://www.ncbi.nlm.nih.gov/pubmed/16801668 High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine. https://www.ncbi.nlm.nih.gov/pubmed/22610053 12) Probiotics Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease (Cell. 2016) http://www.cell.com/cell/fulltext/S0092-8674%2816%2931590-2 Use of probiotics for the treatment of constipation in Parkinson's disease patients. https://www.ncbi.nlm.nih.gov/pubmed/21587143 The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies (Eur J Pharmacol. 2017) http://www.sciencedirect.com/science/article/pii/S0014299917303734#bib66 13) Milk Thistle (silymarin) Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization. https://www.ncbi.nlm.nih.gov/pubmed/25677261 14) Fisetin The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease. (J Parkinsons Dis. 2012) https://www.ncbi.nlm.nih.gov/pubmed/23938259 15) Apigenin Curcumin and Apigenin – novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease (Neural Regen Res. 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590215/ Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. https://www.ncbi.nlm.nih.gov/pubmed/28389404 16) Nicotinamide Riboside (NR) (NAD+ precursor) Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease (Biol Open. 2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312101/ Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders (Clin Transl Med. 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963347/ 17) Nobiletin & Tangeretin Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease. (J Med Food. 2015) https://www.ncbi.nlm.nih.gov/pubmed/25325362 Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease. https://www.ncbi.nlm.nih.gov/pubmed/28474543 18) Bacopa monnieri Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.(Biochem Biophys Res Commun. 2011) https://www.ncbi.nlm.nih.gov/pubmed/21925152 19) L-theanine l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018574/ 20) Vitamin D Serum vitamin D and the risk of Parkinson disease. https://www.ncbi.nlm.nih.gov/pubmed/20625085 Systematic Review of the Relationship between Vitamin D and Parkinson’s Disease (J Parkinsons Dis. 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927872/ 21) Phosphatidylserine (PS) Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT). https://www.ncbi.nlm.nih.gov/pubmed/2690093 22) Olive Oil & Oleuropein Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model (Int. J. Mol. Sci. 2016) http://www.mdpi.com/1422-0067/17/8/1293/htm 23) Mucuna Pruriens Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study. (J Neurol Neurosurg Psychiatry. 2004) https://www.ncbi.nlm.nih.gov/pubmed/15548480 An alternative medicine treatment for Parkinson's disease: results of a multicenter clinical trial. HP-200 in Parkinson's Disease Study Group. (J Altern Complement Med. 1995) https://www.ncbi.nlm.nih.gov/pubmed/9395621 24) Magnesium L-threonate Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial (J Alzheimers Dis. 2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927823/
-------------------- Rating: 3 (2 votes) — Views: 9007 — Updated: 2017-09-03
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