Has anyone tried to list all theories of t...
Danail Bulgaria 05 Nov 2011
If there is not such a list, it will be nice we to make a list like that.
Here are the theories, that I know of:
Wear and tear theory
Cholesterol theory for aging
Theory for accumulation of genetic mutations
Theory of depletion of cellular devidings
Theory of shortening of the telomeres
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Aging as provoked from inflammation (no matter if microbal and aseptical)
Oxydative damage theory
Immune detoriation theory
Hormonal disbalance theory
The theory as provoked from the central neurous system
Theory of intracellular "garbage" accumulation
Please, feel free to add more and more theories, that You know of.
Edited by Mind, 04 April 2012 - 07:37 PM.
VidX 08 Nov 2011
Mind 08 Nov 2011
Here is an older article I have used in the past, kind-of a historical review.
Of course there is SENS and the 7 deadly things.
There is also this older thread from Imminst about everyone's favorite definition of aging.
Danail Bulgaria 24 Nov 2011
I have listed the newely suggested theories in the list. However, I need some help to determine if some theories are not added twice with different names. I went on the SENS web site, but could not find the seven deadly things. Would You please list them?
So, so far the list with the aging theories (listed alphabetically) is:
Accumulative-Waste Theory
Activity theory
Aging as programmed process =? Planned Obsolescence Theory
Aging as provoked from inflammation (no matter if microbal and aseptical)
Autoimmune Theory
Cholesterol theory for aging
Continuity Theory
Cross-Linkage Theory
Disengagement Theory
DNA damage theory
Error Accumulation Theory
Evolutionary theory of aging (M.R.Rose).
Free radicals theory =? Oxydative damage theory
Hormonal disbalance theory
Hayflick Limit Theory
Immune detoriation theory
Misrepair-Accumulation Theory
Mitochondrial Decline Theory
Mitohormesis
The Neuroendocrine Theory of Professor Vladimir Dilman
Oxydative damage theory =? Free radicals theory
Planned Obsolescence Theory =? Aging as programmed process
Reliability theory of ageing and longevity
Reproductive-Cell Cycle Theory
Selectivity Theory
Somatic Mutation Theory =? Theory for accumulation of genetic mutations
Telomere Theory
Telomerase Theory of Aging
Theory for accumulation of genetic mutations =? Somatic Mutation Theory
Theory of depletion of cellular devidings
Theory of shortening of the telomeres
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
The theory as provoked from the central neurous system
Theory of intracellular "garbage" accumulation
Wear and tear theory
Danail Bulgaria 25 Dec 2011
The final list of aging theories so far is:
1.5bn Heart Beat Theory (http://www.npr.org/t...toryId=12877984)
Accumulative-Waste Theory
Activity theory
Aging as programmed process =? Planned Obsolescence Theory
Aging as provoked from inflammation (no matter if microbal and aseptical)
Autoimmune Theory
Cholesterol theory for aging
Continuity Theory
Cross-Linkage Theory
Disengagement Theory
DNA damage theory
Error Accumulation Theory
Evolutionary theory of aging (M.R.Rose).
Free radicals theory =? Oxydative damage theory
Hormonal disbalance theory
Hayflick Limit Theory
Immune detoriation theory
Misrepair-Accumulation Theory
Mitochondrial Decline Theory
Mitohormesis
The Neuroendocrine Theory of Professor Vladimir Dilman
Oxydative damage theory =? Free radicals theory
Planned Obsolescence Theory =? Aging as programmed process
Reliability theory of ageing and longevity
Reproductive-Cell Cycle Theory
Selectivity Theory
Somatic Mutation Theory =? Theory for accumulation of genetic mutations
Telomere Theory
Telomerase Theory of Aging
Theory for accumulation of genetic mutations =? Somatic Mutation Theory
Theory of depletion of cellular devidings
Theory of shortening of the telomeres
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
The theory as provoked from the central neurous system
Theory of intracellular "garbage" accumulation
Wear and tear theory
Danail Bulgaria 25 Dec 2011
The list of aging theories:
1.5bn Heart Beat Theory (http://www.npr.org/t...toryId=12877984)
Accumulative-Waste Theory
Activity theory
Aging as programmed process =? Planned Obsolescence Theory
Aging as provoked from inflammation (no matter if microbal and aseptical)
Autoimmune Theory
Cholesterol theory for aging
Continuity Theory
Cross-Linkage Theory
Disengagement Theory
DNA damage theory
Error Accumulation Theory
Evolutionary theory of aging (M.R.Rose).
Free radicals theory =? Oxydative damage theory
HORMONAL THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman
HGH (human growth hormone) theory
TSH low levels theory
Hayflick Limit Theory
Immune detoriation theory
Misrepair-Accumulation Theory
Mitochondrial Decline Theory
Mitohormesis
Oxydative damage theory =? Free radicals theory
Planned Obsolescence Theory =? Aging as programmed process
Reliability theory of ageing and longevity
Reproductive-Cell Cycle Theory
Selectivity Theory
Somatic Mutation Theory =? Theory for accumulation of genetic mutations
Telomere Theory
Telomerase Theory of Aging
Theory for accumulation of genetic mutations =? Somatic Mutation Theory
Theory of depletion of cellular devidings
Theory of shortening of the telomeres
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
The theory as provoked from the central neurous system
Theory of intracellular "garbage" accumulation
Wear and tear theory
brokenportal 08 Feb 2012
Many of these it seems can be summed up as SENS, so we could take out depletion of cells, mitochondrial decline, possibly take out dna damage, cross linking, etc.. Is it argued anywhere that any of the 7 alone or in groups of less than 7 could bring about indefinite life extension? Telomeres comes to mind for that one but Im not sure, as far as I know if you fixed the telomere dilemma, you would still have to contend with the other 6 forms of damage accumulation.
So besides SENS, the only one that I know of so far that is in serious contention to potentially bring about indefinite life extension is what you seem to have listed as all of these, which I think are the same thing, and worked on by more than Michael Rose.
Aging as programmed process =? Planned Obsolescence Theory
Evolutionary theory of aging (M.R.Rose)
Planned Obsolescence Theory =? Aging as programmed process
Free radical theory and mitohormesis seem to be taken care of by mitosens. Cholesterol is something we can take care of with out radical ant aging intervention it seems. Ill have to read up on hormonal theory, I remember seeing some arguments for it.
Danail Bulgaria 09 Feb 2012
In such a new topic the strategies there may be listed, and their connection with the aging theories may be added like something like that:
1) Lenghtening the telomeres - in accordance to the theories of depletion of cells, the telomerase theory of aging and the telomere theory of aging.
2) Receiving antioxydants - in accordance with the oxydative damage theory and the free radicals theory.
etc.
niner 09 Feb 2012
Aging Damage / Discovery / SENS Solution
Cell loss, tissue atrophy / 19551 Stem cells and tissue engineering (RepleniSENS)
Nuclear [epi]mutations / 19592, 19823 Removal of telomere-lengthening machinery (OncoSENS)
Mutant mitochondria / 19724 Allotopic expression of 13 proteins (MitoSENS)
Death-resistant cells / 19655 Targeted ablation (ApoptoSENS)
Tissue stiffening / 19586, 19817 AGE-breaking molecules (GlycoSENS); tissue engineering
Extracellular aggregates / 19078 Immunotherapeutic clearance (AmyloSENS)
Intracellular aggregates / 19599 Novel lysosomal hydrolases (LysoSENS)
Edited by niner, 09 February 2012 - 01:40 AM.
Danail Bulgaria 09 Feb 2012
Sometimes the differences in the interpretation of the theories is very tiny. For example the telomere theory claims, that telomere shortening are the reason for the cells to age, however as far as I know it is not so far proven, that telomerase is the only one factor, that affects the telomeres length, so according to me it will be better to be listed the both factors as separate teories. Moreover, since the telomere theory is a theory, it is not a sure prove, that the Hayflick limit is due only to the telomeres of the cell. Ofcourse I may not be right, but this is the forum for - to be taken some sort of unanimously decision. I think, that a biogerontologist will be the best person to explain if there are tiny differences among these theories, and if so are there enough arguments for them to be put in separate or they have to be united in one theory.
Danail Bulgaria 09 Feb 2012
Danail Bulgaria 09 Feb 2012
*Extracellular aggregates accumulation / 1907 http://www.sens.org/...hemes/amylosens
*Intracellular aggregates accumulation / 1959 http://www.sens.org/...themes/lysosens
Theory of cholesterol accumulation
Theory of amyloid accumulation
DNA damage accumulation theory
Error Accumulation Theory
Misrepair-Accumulation Theory: Wang et al. suggest that ageing is the result of the accumulation of "Misrepair"
Theory for accumulation of genetic mutations = Somatic Mutation Theory
Theory of intracellular "garbage" accumulation in the human body
THEORIES OF DEPLETION
Hayflick Limit Theory http://en.wikipedia..../Hayflick_limit
*Theory of depletion of cellular devidings
*Metabolic rate depletion theory http://prolongyouth....f-Living-Theory
BIOLOGICAL THEORIES
1.5bn Heart Beat Theory (http://www.npr.org/t...toryId=12877984)
Activity reduction theory
Reproductive-Cell Cycle Theory http://en.wikipedia....ll_cycle_theory
Selectivity Theory
Calorie Restriction Theory http://www.anti-agin...restriction.htm
The Membrane Theory of Aging http://www.anti-agin...ry/membrane.htm
*Death-resistant cells / 1965 http://www.sens.org/...emes/apoptosens
*Tissue stiffening / 1958, 1981 http://www.sens.org/...hemes/glycosens
IMUNOLOGICAL THEORIES
Aging as provoked from inflammation (no matter if microbal and aseptical)
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Autoimmune Theory
Immune detoriation theory
PSYCHOLOGICAL THEORIES
Continuity Theory http://en.wikipedia....y_theory_(aging)
Disengagement Theory http://en.wikipedia....gagement_theory
GENETIC THEORIES
Aging as programmed process = Planned Obsolescence Theory
*DNA damage theory
*DNA accumulation damage theory = Somatic Mutation Theory
*Telomere Theory
*Telomerase Theory of Aging
Redundant DNA Theory http://www.anti-agin...dundant-dna.htm
Gene Mutation Theory http://prolongyouth....Mutation-Theory
INTOXICATION THEORIES
Mitohormesis http://en.wikipedia.org/wiki/Hormesis
BIOCHEMICAL THEORIES
Cross-Linkage Theory http://prolongyouth....-Linkage-Theory
Free radicals theory = Oxydative damage theory
*Mitochondrial Decline Theory http://www.anti-agin...ial-decline.htm
The Acidification Theory of Aging http://www.anti-agin...idification.htm
*Mutant mitochondria / 1972 Allotopic expression of 13 proteins
EVOLUTIONARY THEORIES
Evolutionary theory of aging (M.R.Rose)
NEUROENDOCRINE THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman = The theory as provoked from the central neurous system
HGH (human growth hormone) theory
TSH low levels theory
Death Hormone Theory (DECO) http://www.anti-agin...ath-hormone.htm
Thymic Insufience Theory http://www.anti-agin...stimulating.htm
Metabolic rate depletion theory http://prolongyouth....f-Living-Theory
WEAR AND TEAR THEORIES
Wear and tear theory (general)
Reliability theory of ageing and longevity http://en.wikipedia....g_and_longevity
COMBINATION BETWEEN THE THEORIES
Virtually a large number of theories may be produced by combining two or more theories and thus shaping new theory.
Marios Kyriazis 09 Feb 2012
http://www.ncbi.nlm....pubmed/20662589
also here:
http://www.ncbi.nlm....pubmed/12766532
This holds that aging is due to loss of biological complexity and sophistication, and that if we try to increase input of information and complex challenges, then we may be able to slow down the process
Danail Bulgaria 10 Feb 2012
Danail Bulgaria 10 Feb 2012
*Extracellular aggregates accumulation / 1907 http://www.sens.org/...hemes/amylosens
*Intracellular aggregates accumulation / 1959 http://www.sens.org/...themes/lysosens
Theory of cholesterol accumulation
Theory of amyloid accumulation
DNA damage accumulation theory
Error Accumulation Theory
Misrepair-Accumulation Theory: Wang et al. suggest that ageing is the result of the accumulation of "Misrepair"
Theory for accumulation of genetic mutations = Somatic Mutation Theory
Theory of intracellular "garbage" accumulation in the human body
THEORIES OF DEPLETION
Hayflick Limit Theory http://en.wikipedia..../Hayflick_limit
*Theory of depletion of cellular devidings
*Metabolic rate depletion theory http://prolongyouth....f-Living-Theory
There is another theory, the loss of complexity in aging http://www.ncbi.nlm....pubmed/20662589
BIOLOGICAL THEORIES
1.5bn Heart Beat Theory
Activity reduction theory
Reproductive-Cell Cycle Theory http://en.wikipedia....ll_cycle_theory
Selectivity Theory
Calorie Restriction Theory http://www.anti-agin...restriction.htm
The Membrane Theory of Aging http://www.anti-agin...ry/membrane.htm
*Death-resistant cells / 1965 http://www.sens.org/...emes/apoptosens
*Tissue stiffening / 1958, 1981 http://www.sens.org/...hemes/glycosens
IMUNOLOGICAL THEORIES
Aging as provoked from inflammation (no matter if microbal and aseptical)
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Autoimmune Theory
Immune detoriation theory
PSYCHOLOGICAL THEORIES
Continuity Theory http://en.wikipedia....y_theory_(aging)
Disengagement Theory http://en.wikipedia....gagement_theory
GENETIC THEORIES
Aging as programmed process = Planned Obsolescence Theory
*DNA damage theory
*DNA accumulation damage theory = Somatic Mutation Theory
*Telomere Theory
*Telomerase Theory of Aging
Redundant DNA Theory http://www.anti-agin...dundant-dna.htm
Gene Mutation Theory http://prolongyouth....Mutation-Theory
INTOXICATION THEORIES
Mitohormesis http://en.wikipedia.org/wiki/Hormesis
BIOCHEMICAL THEORIES
Cross-Linkage Theory http://prolongyouth....-Linkage-Theory
Free radicals theory = Oxydative damage theory
*Mitochondrial Decline Theory http://www.anti-agin...ial-decline.htm
The Acidification Theory of Aging http://www.anti-agin...idification.htm
*Mutant mitochondria / 1972 Allotopic expression of 13 proteins
EVOLUTIONARY THEORIES
Evolutionary theory of aging (M.R.Rose)
NEUROENDOCRINE THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman = The theory as provoked from the central neurous system
HGH (human growth hormone) theory
TSH low levels theory
Death Hormone Theory (DECO) http://www.anti-agin...ath-hormone.htm
Thymic Insufience Theory http://www.anti-agin...stimulating.htm
Metabolic rate depletion theory http://prolongyouth....f-Living-Theory
WEAR AND TEAR THEORIES
Wear and tear theory (general)
Reliability theory of ageing and longevity http://en.wikipedia....g_and_longevity
COMBINATION BETWEEN THE THEORIES
Virtually a large number of theories may be produced by combining two or more theories and thus shaping new theory.
Marios Kyriazis 12 Feb 2012
Danail Bulgaria 12 Feb 2012
Another theory, that is close to Your thoughts is the damage accumulation theory. However, I didn't add it, because I could not find differences between it and the wear and tear theory.
I have heared also about the dispossible soma theory, but I am not sure what does it postulates.
Are those thoughts differ from the above theories? If there is a difference, I will add this theory in the list of theories.
Marios Kyriazis 12 Feb 2012
Danail Bulgaria 12 Feb 2012
THEORIES OF ACCUMULATION
*Extracellular aggregates accumulation / 1907
*Intracellular aggregates accumulation / 1959
Theory of cholesterol accumulation
Theory of amyloid accumulation
DNA damage accumulation theory
Error Accumulation Theory
Misrepair-Accumulation Theory: Wang et al. suggest that ageing is the result of the accumulation of "Misrepair"
Theory for accumulation of genetic mutations = Somatic Mutation Theory
Theory of intracellular "garbage" accumulation in the human body
THEORIES OF DEPLETION
Hayflick Limit Theory
*Theory of depletion of cellular devidings
*Metabolic rate depletion theory
There is another theory, the loss of complexity in aging
BIOLOGICAL THEORIES
1.5bn Heart Beat Theory
Activity reduction theory
Reproductive-Cell Cycle Theory
Selectivity Theory
Calorie Restriction Theory
The Membrane Theory of Aging
*Death-resistant cells / 1965
*Tissue stiffening / 1958, 1981
IMUNOLOGICAL THEORIES
Aging as provoked from inflammation (no matter if microbal and aseptical)
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Autoimmune Theory
Immune detoriation theory
PSYCHOLOGICAL THEORIES
Continuity Theory
Disengagement Theory
GENETIC THEORIES
Aging as programmed process = Planned Obsolescence Theory
*DNA damage theory
*DNA accumulation damage theory = Somatic Mutation Theory
*Telomere Theory
*Telomerase Theory of Aging
Redundant DNA Theory
Gene Mutation Theory
INTOXICATION THEORIES
Mitohormesis http://en.wikipedia.org/wiki/Hormesis
BIOCHEMICAL THEORIES
Cross-Linkage Theory
Free radicals theory = Oxydative damage theory
*Mitochondrial Decline Theory
The Acidification Theory of Aging
*Mutant mitochondria / 1972 Allotopic expression of 13 proteins
EVOLUTIONARY THEORIES
Evolutionary theory of aging (M.R.Rose)
The Disposable Soma Theory
NEUROENDOCRINE THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman = The theory as provoked from the central neurous system
HGH (human growth hormone) theory
TSH low levels theory
Death Hormone Theory (DECO)
Thymic Insufience Theory
Metabolic rate depletion theory
WEAR AND TEAR THEORIES
Wear and tear theory (general)
Reliability theory of ageing and longevity
COMBINATION BETWEEN THE THEORIES
Virtually a large number of theories may be produced by combining two or more theories and thus shaping new theory.
Danail Bulgaria 12 Feb 2012
Here is it again:
THEORIES OF ACCUMULATION
*Extracellular aggregates accumulation / 1907
*Intracellular aggregates accumulation / 1959
Theory of cholesterol accumulation
Theory of amyloid accumulation
DNA damage accumulation theory
Error Accumulation Theory
Misrepair-Accumulation Theory: Wang et al. suggest that ageing is the result of the accumulation of "Misrepair"
Theory for accumulation of genetic mutations = Somatic Mutation Theory
Theory of intracellular "garbage" accumulation in the human body
THEORIES OF DEPLETION
Hayflick Limit Theory
*Theory of depletion of cellular devidings
*Metabolic rate depletion theory
There is another theory, the loss of complexity in aging
BIOLOGICAL THEORIES
1.5bn Heart Beat Theory
Activity reduction theory
Reproductive-Cell Cycle Theory
Selectivity Theory
Calorie Restriction Theory
The Membrane Theory of Aging
*Death-resistant cells / 1965
*Tissue stiffening / 1958, 1981
IMUNOLOGICAL THEORIES
Aging as provoked from inflammation (no matter if microbal and aseptical)
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Autoimmune Theory
Immune detoriation theory
PSYCHOLOGICAL THEORIES
Continuity Theory
Disengagement Theory
GENETIC THEORIES
Aging as programmed process = Planned Obsolescence Theory
*DNA damage theory
*DNA accumulation damage theory = Somatic Mutation Theory
*Telomere Theory
*Telomerase Theory of Aging
Redundant DNA Theory
Gene Mutation Theory
INTOXICATION THEORIES
Mitohormesis http://en.wikipedia.org/wiki/Hormesis
BIOCHEMICAL THEORIES
Cross-Linkage Theory
Free radicals theory = Oxydative damage theory
*Mitochondrial Decline Theory
The Acidification Theory of Aging
*Mutant mitochondria / 1972 Allotopic expression of 13 proteins
EVOLUTIONARY THEORIES
Evolutionary theory of aging (M.R.Rose)
The Disposable Soma Theory
NEUROENDOCRINE THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman = The theory as provoked from the central neurous system
HGH (human growth hormone) theory
TSH low levels theory
Death Hormone Theory (DECO)
Thymic Insufience Theory
Metabolic rate depletion theory
WEAR AND TEAR THEORIES
Wear and tear theory (general)
Reliability theory of ageing and longevity
COMBINATION BETWEEN THE THEORIES
Virtually a large number of theories may be produced by combining two or more theories and thus shaping new theory.
Danail Bulgaria 15 Feb 2012
Marios Kyriazis 15 Feb 2012
mrszeta, You wrote, that according to You the aging is due to a process in which "the rate of damage exceeds the rate of repair". From that, I think, that You suppose, that there exists some sort of balance between the two rates - the rate of damage and the rate of repair. If this is so, then there are some differences between Your theory and the wear and tear theories and the dispossible soma theory. I was reading for awhile about these theories, however, I didn't find such a balance or equilibrium, that suggests the rate of damage exceeds the rate of repair. So, if I am right, and if You don;t mind, Your theory may be included into the list of the theories. Can Your theory be formulated as theory for disrupting of the balance between the rate of repair and the rate of damage?
The rate of damage vs repair is not my own personal theory, but I happen to support the idea.
There is a balance between the rate of damage and that of repair - the two processes try to 'take each other over', and the result is that we manage to live to the age of around 80-120 before the rate of damage takes over completely and we die. At a deeper level, I see it as Physics trying to increase damage (trhough friction, gravity, entropy etc) whereas Biology is trying to balance this by increasing the rate of repair (through innate mechanisms that increase biological complexity). The Disposable Soma theory merely states that the rate of repair is diminished because the energy resources are depleted. I am saying that we can increase the rate of repair (and thus live longer) by increasing biological sophistication via a variety of means, which I have already discussed elsewhere:
https://skydrive.liv...91D98A0F83A!141
Danail Bulgaria 16 Feb 2012
Danail Bulgaria 20 Feb 2012
The final list of the aging theories is:
THEORIES OF ACCUMULATION
*Extracellular aggregates accumulation / 1907
*Intracellular aggregates accumulation / 1959
Theory of cholesterol accumulation
Theory of amyloid accumulation
DNA damage accumulation theory
Error Accumulation Theory
Misrepair-Accumulation Theory: Wang et al. suggest that ageing is the result of the accumulation of "Misrepair"
Theory for accumulation of genetic mutations = Somatic Mutation Theory
Theory of intracellular "garbage" accumulation in the human body
THEORIES OF DEPLETION
Hayflick Limit Theory
*Theory of depletion of cellular devidings
*Metabolic rate depletion theory
There is another theory, the loss of complexity in aging
BIOLOGICAL THEORIES
1.5bn Heart Beat Theory
Activity reduction theory
Reproductive-Cell Cycle Theory
Selectivity Theory
Calorie Restriction Theory
The Membrane Theory of Aging
*Death-resistant cells / 1965
*Tissue stiffening / 1958, 1981
IMUNOLOGICAL THEORIES
Aging as provoked from inflammation (no matter if microbal and aseptical)
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Autoimmune Theory
Immune detoriation theory
PSYCHOLOGICAL THEORIES
Continuity Theory
Disengagement Theory
GENETIC THEORIES
Aging as programmed process = Planned Obsolescence Theory
*DNA damage theory
*DNA accumulation damage theory = Somatic Mutation Theory
*Telomere Theory
*Telomerase Theory of Aging
Redundant DNA Theory
Gene Mutation Theory
INTOXICATION THEORIES
Mitohormesis http://en.wikipedia.org/wiki/Hormesis
BIOCHEMICAL THEORIES
Cross-Linkage Theory
Free radicals theory = Oxydative damage theory
*Mitochondrial Decline Theory
The Acidification Theory of Aging
*Mutant mitochondria / 1972 Allotopic expression of 13 proteins
EVOLUTIONARY THEORIES
Evolutionary theory of aging (M.R.Rose)
The Disposable Soma Theory
NEUROENDOCRINE THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman = The theory as provoked from the central neurous system
HGH (human growth hormone) theory
TSH low levels theory
Death Hormone Theory (DECO)
Thymic Insufience Theory
Metabolic rate depletion theory
WEAR AND TEAR THEORIES
Wear and tear theory (general)
Reliability theory of ageing and longevity
DHA-Accelerated Aging Hypothesis
COMBINATION BETWEEN THE THEORIES
Virtually a large number of theories may be produced by combining two or more theories and thus shaping new theory.
Danail Bulgaria 20 Mar 2012
THEORIES OF ACCUMULATION
*Extracellular aggregates accumulation / 1907 http://www.sens.org/...hemes/amylosens
*Intracellular aggregates accumulation / 1959 http://www.sens.org/...themes/lysosens
Theory of cholesterol accumulation
Theory of amyloid accumulation
DNA damage accumulation theory
Error Accumulation Theory
Misrepair-Accumulation Theory: Wang et al. suggest that ageing is the result of the accumulation of "Misrepair"
Theory for accumulation of genetic mutations = Somatic Mutation Theory
Theory of intracellular "garbage" accumulation in the human body
THEORIES OF DEPLETION
Hayflick Limit Theory http://en.wikipedia..../Hayflick_limit
*Theory of depletion of cellular devidings
*Metabolic rate depletion theory http://prolongyouth....f-Living-Theory
There is another theory, the loss of complexity in aging http://www.ncbi.nlm....pubmed/20662589
BIOLOGICAL THEORIES
1.5bn Heart Beat Theory
Activity reduction theory
Reproductive-Cell Cycle Theory http://en.wikipedia....ll_cycle_theory
Selectivity Theory
Calorie Restriction Theory http://www.anti-agin...restriction.htm
The Membrane Theory of Aging http://www.anti-agin...ry/membrane.htm
*Death-resistant cells / 1965 http://www.sens.org/...emes/apoptosens
*Tissue stiffening / 1958, 1981 http://www.sens.org/...hemes/glycosens
IMUNOLOGICAL THEORIES
Aging as provoked from inflammation (no matter if microbal and aseptical)
The microorganisms theory, that is being discussed in the Aging Theories section of this forum
Autoimmune Theory
Immune detoriation theory
PSYCHOLOGICAL THEORIES
Continuity Theory http://en.wikipedia....y_theory_(aging
Disengagement Theory http://en.wikipedia....gagement_theory
GENETIC THEORIES
Aging as programmed process = Planned Obsolescence Theory
*DNA damage theory
*DNA accumulation damage theory = Somatic Mutation Theory
*Telomere Theory
*Telomerase Theory of Aging
Redundant DNA Theory http://www.anti-agin...dundant-dna.htm
Gene Mutation Theory http://prolongyouth....Mutation-Theory
INTOXICATION THEORIES
Mitohormesis http://en.wikipedia.org/wiki/Hormesis
BIOCHEMICAL THEORIES
Cross-Linkage Theory http://prolongyouth....-Linkage-Theory
Free radicals theory = Oxydative damage theory
*Mitochondrial Decline Theory http://www.anti-agin...ial-decline.htm
The Acidification Theory of Aging http://www.anti-agin...idification.htm
*Mutant mitochondria / 1972 Allotopic expression of 13 proteins
EVOLUTIONARY THEORIES
Evolutionary theory of aging (M.R.Rose)
The Disposable Soma Theory
NEUROENDOCRINE THEORIES
Hormonal disbalance theory
The Neuroendocrine Theory of Professor Vladimir Dilman = The theory as provoked from the central neurous system
HGH (human growth hormone) theory
TSH low levels theory
Death Hormone Theory (DECO) http://www.anti-agin...ath-hormone.htm
Thymic Insufience Theory http://www.anti-agin...stimulating.htm
Metabolic rate depletion theory http://prolongyouth....f-Living-Theory
WEAR AND TEAR THEORIES
Wear and tear theory (general)
Reliability theory of ageing and longevity http://en.wikipedia....g_and_longevity
DHA-Accelerated Aging Hypothesis
COMBINATION BETWEEN THE THEORIES
*The Russian scheme for the aging http://www.sciencevs...0.5.4_final.jpg
Virtually a large number of theories may be produced by combining two or more theories and thus shaping new theory.
treonsverdery 29 Mar 2012
I think this may be a new theory, I may have written about it here previously.
cytomorphology effects cytokine activity causing misregulation of cytosystems. or "histology surface change quantitatively reregulates tissue" http://www.longecity...hat-treat-this/
basically as tissues accumulate shape change, their actual chemical messengering with neighbors changes, modifying tissue activity, causing symptoms.
Imagine a bunch of perfect spheres packed together, they all just slightly touch, now imagine a bunch of water ballons packed together, massive surface contact right?
each sphere or water balloon is covered with receptors as well as secreting chemicals, so the amount of chemicals the heaped spheres would transmit, or be able to receive might be a hundredth that of the heaped water balloons. Thus shape change alone can regulate cytomessaging more than an order of magnitude or two. When scientists study the shape of elderly tissue (histology) it is obviously different than younger tissue thus the actual receptor densitity, secretion density, actual contact area parameters could be measured. Then cytomorphology (cytoshape) drugs could be tried to see if drugs that caused greater similarity to youthful contact area also created greater longevity.
an undergrad way to test this would be plate tissue culture of a mammalian tissue, preferably human, grow one right side up, the other upside down(or even centrifuged), then verify the cytes were different shapes from gravity, then see if the hayflick effect was different (a measure of longevity)just from the surface area effect.
Also potentially rather similar to the psychology theories is that elderly humans live longer when exposed to children (pubmed reference) now one approach is to believe this has to do with psychological participation, or cognitive stimulation, yet it could also be a result of immunological or pheremonal effects. college humans apparently modify their heart rate as well as attentiveness as a result of smelling t shirts others have worn, thus there could be chemical effects here as well.
Then there is the engineering approach to efficacy.
One of the things Aubrey has written of is that scientists differ from engineers, engineers are driven to accomplish a technological accomplishment while scientists create new knowledge. To Aubrey, the way no scientist has simply combined say the top ten pharmacological longevity medicines at a huge quantity of mice to find the most effective current solution to aging is because to a scientist, at a scientific culture, thats kind of different than creating new knowledge. I strongly value basic reasearch as well as applied technology. Thus there is also the engineering perspective to cure aging. Actually scientists might call this empiricism, "try building on what works, create application notes as well as theory on the way" brings new actual knowledge to light as well
There is also the possibilityof a chronoregulation theory. Viewing this video provides the data graph.
40,980 Norwegian siblings were ranked on IQ similarity along numerous decades. The heritability of IQ ranged between about .23 to .87, following an obviously discerable curve with time. Thus all kinds of other genetic things things like susceptibility to disease may also vary their heritability gradually.
untitled.PNG 1.41MB 3 downloads
Such a chronoeffect would have very meaningful effects on the study of aging as there is apparently an outside effect on gene expression that has not yet been described. Notably do lab mice also have a regularly changing curve of genetic heritability of traits that is on the same schedule as humans, or does theirs oscillate much faster? That would determine if it was a area EM(electromagnetic) or EMlike effect, or some other effect
http://www.youtube.com/watch?v=lluQz9CagG4
Edited by treonsverdery, 29 March 2012 - 09:29 PM.
Danail Bulgaria 30 Mar 2012
However, I couldn't fully understand what do You mean.
As far as I understand, You are supposing several theories:
1. Theory, that the aging is caused by change in the cytosurface, which influences the receptors of the cells.
2. Theory, that the process of aging is caused by insuficient psychological participation, or cognitive stimulation.
3. A chronoregulation theory, according to which the regulation of our genes is decreasing slowly with time.
4. Theory, that the aging is caused by an electromagnetic or EMlike (electromagnetic like?) effect.
Please, answer if I have understood You correctly, so the theories to be added in the list.
treonsverdery 04 Apr 2012
2 actually what looks like psychological stimulation could also be explained with something like pheremones, that is noting that at other stdies sniffing t shirts changes heart rate as well as attentiveness, if you have an elderly person have a slightly different heart rate or attentiveness over a while, it could actually affect their longevity as a sepearate chemical process similar to what scientists call quorum sensing , similarly mice exposed to the scent of crowded mice or attractrive mice might have different lifespans, although that might blend chemoresponse with information content. to the humans the t shirts were apparently identical as well as unscented.
3 as well as 4 a chronoVariation theory, where genetic determinacy goes up or down gradually yet rather than time being the source of the effect a different thing is the source of the effect
There are also spiritual technology theories of aging as well, I think these have been described as morphogenic fields The one I heard about yet have not tried is that people that have voluntary sex with virgins have greater physiological well being thus may live longer. You can see how if it works it is a new theory. It is easily tested Just have mice breed only with virgin mice or sexually experienced mice then see if it affects their longevity. some people might also be willing to try this with humans. They could also try this with nonhuman primates as well. The similarity or contrast of the results (works with each or some) could be traced to either spiritual technology or chemistry.
another aging theory that is actually so obvious it is kind of part of other theories yet not listed is the proteome difference theory. scientists routinely measure the proteome or all proteins made n their paths of action at tissues. young tissue has a different specific proteins produced, at different amounts, at different raters of production than old tissue. the scientists often make charts of the mRNA (protein making instructions) difference of activity between two groups like at the expression graph at http://www.ncbi.nlm....e-0023652-g004/
I say this is obvious because when a supplements user takes a pill that causes the body to make a younger level of a particular chemical they are already doing this
You could say the Activity or keep busy theory is also meaningful. Astronauts must exercise to keep from dwindling, mental tasks apparently give greater durability of cognition, so noting that caffeine reduces mouse alzheimers 70 pct, is it the chemical or some kind of mental stimulation that causes the maintained youthful response. Hormesis is the observation that challenge builds greater well being than absence of challenge at certain circumstances. Compared with astronauts earth dwellers just think exercise is natural.
treonsverdery 10 Apr 2012
it could be called the buffered environment or perfect nutrient theory
Neurons live over a century
Other tissues rotate all their cytes out every 7 years
Thus neurons have a high degree of longevity compared with other human tissues
This could because of the blood brain barrier(BBB), basically epithilial cytes right next to every neuron superfilter as well as regularize all of the ions nutrients cytokines that the neurons feel. Thus it could be that superperfect blood chemistry would cause vastly greater longevity, or it could be that the physical support of the BBB as well as the brain tissue known as glia, causes the neurons to always have a regularized physical shape thus always maintaining their cytokine communications functionality rather like the histology surface change quantitatively reregulates tissue
if you combine regulation of when cytes are replaced with higher quality body fluids possibly other human tussues would last as long as neurons, possibly multiplying organism longevity many times.
Now, whats wrong with this idea? well, mice. Mice get senile before humans reach kindergarten yet mice have blood brain barriers. so some other programmed effect may be causing multisystem senescence. The human brain keeps growing until age 10 or beyond, after most mice are thrice dead. so rather than a superfilter explanation some kind of organismal program is likely. However, scientists frequently find that soaking tissue cultures with things like long lived animal chemicals (jellyfish, NDGA from plants) makes the tissue live longer so there is also support of a superfilter theory.