Here is a possibly novel theory of aging noncancerous yet anomoulously ordered surface receptor groupings at the cytosurface cause varied chemoenvironment thus causing erratic cytobehavior, notably multicyte longevity as well as changes to the hayflick effect as well as a couple possible medications to reduce aging.
I think scientists could study rate of upgunk at the cytosurface, or create multielement description of cytosurface change linked to hayflick effect. the effect where cytes only divide a certain number of times.
visualize a young cyte, well say its receptors are spaced regularly like
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the view an older cyte, perhaps its receptors are spaced like
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that is the surface of the cyte shows messy room syndrome, irregular groupings or areas with fewer receptors.
If this receptor orderliness change "progresses" that is is linked to the hayflick effect, then it is reasonable to link the clustering or spacing of receptors to information transmission effectiveness. Notice that with mapping there are new categories: general wackiness (mess) as well as new describable geometries of clustering or spacing(.
so there more here than the different testably hypotheses just "more mess, less long" or " fewer triplets causes less function" Theres the idea that the actual spatiality of cytopatterns affects longevity. im kind of saying, haflick is a measure, a cytosurface could be like a map. mapping creates more things to measure.
An actual longevity drug creation technology
visualize a plate culture of hayflick cytes,
This is actually at a sandwich, where the fluid flow is directly up or sideways. If its sideways then cytokines like messenger chemicals spread between cytes, if fluid flow is straight up, then the cytes are more chemoisolated. Compare these two nutrient movement ways, to see if one or the opther is better, then see what the minimum sideways radius is to create that difference, that area sugests the actual concentration amount of the chemicals that cause the change. then you could make a version, where the glommingly shaped proteins called antibodies are placed at the tissue culture to find any specific cytokine that is actually linked to different longevity. so thats a way to find the right dose of the right chemical.
if its beneficial you can then make more of it, otherwise you could immunize against it or develop drugs that reduced production of the naughty cytokine
http://www.ncbi.nlm....pubmed/12200036 says there are specific cytokines that have been linked to aging. "human diploid fibroblasts (HDFs) exposed in vivo and in vitro to pro-inflammatory cytokines display biomarkers of senescence and might participate in the degradation of the extracellular matrix observed in ageing." the part of the article I read did not say though if the hayflick effect was modified.,
The idea of the surface of the cytes receptors being anomolously located causes suddenly greater or lesser responsiveness to naughty or nice cytokines, so we can see how cytosurface order is different than chemoenvironment yet may cause zapareas that suddenly think they are getting too much or too little of a cytochemical. I call that infogunk at the title.
a messy room syndrome modifying drug could then benefit longevity
at the tremendously simple tissue culture perspective then, any chemicals or treatments that reduce messy room syndrome (noncancerous yet anomoulously ordered surface receptor grouping that causes erratic behavior) would benefit between cyte communication, as well as possibly hayflic capacity, which would then be verified as improving tissue as well as organism well being.
so whats a messy room modifying drug, how about a lipid linked to a highly ubiquinated protein. That could cause the cytosurface to be mass flagged to be reconstructed, possibly restoring normal surface geometry. (a molecular biology tome says ubiquinating proteins causes them to be flagged to be recycled, ubiquinating a membrane lipid (rather a protein linked to that lipid) Doofuswise, its possible DHAlinkedto a ubiquinated AEDGAEDGAEDGAEDG protein would become a part of membranes yet its postrecycling presence might be beneficial DHA or the longevity wellness 4 amino acid peptide AEDG, which might be ubiquinationable if the number of AEDG is long enough. The AEDG longevity peptide is described at http://pepbank.mgh.h...s/details/46177 as well as Pubmed.
another possible cytosurface upRegenerating drug would be one of those drugs where they measure that the number of receptors goes up when people use it a lot. Another drug effect, possibly just a brief surplus or deficit of a very common ion, would tell the body to make more potassium or sodium channels, thus refreshing cytosurface.
or a lipid linked to a highly ubiquinated protein with an enzymatically modifiable outer surface. The lipid becomes part of the mebrane uniformly at the cytosurface, yet the ubiquination of the lipid says to the cyte remodel this lipid outta here, the enzymatically modifiable surface gives the lipid time to become part of the membrane prior to remodelling.
Anyways thats a theory of aging (noncancerous yet anomoulously ordered surface receptor groupings that cause varied chemoenvironment causes erratic cytobehavior) as well as a couple possible medications to reduce aging.
Edited by treonsverdery, 25 January 2012 - 09:03 PM.