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LongeCity .                       Advocacy & Research for Unlimited Lifespans


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  • Submitted: May 09 2017 04:40 PM
  • Views: 135

My Stack (good for vegetarians/OCD personalities)

* * * * *
raloxifene dutasteride deprenyl black cumin seed oil mct oil olive oil turmeric black pepper ashwangandha dried parsely (apigenin) bacopa green lipped mussle alcar carnosine nac lithium orotate pqq glycine methyl b12 ubiquinol melatonin

Description

This is my stack, with a few different focuses (note that their are overlaps between categories):

-Anti aging, though I am still fairly young and fairly broke so I'm more conservative and prefer supplements which have proven to extend lifespan in mammals. This includes: deprenyl, raloxifene, turmeric/black pepper, Ashwangandha , Bacopa, Apigenin (dried parsley), NAC, low-dose lithium, PQQ, ubiquinol.
-Nutrients lacking in vegetarian diet: B12, glycine, carnosine, ALCAR, green lipped mussel (DHA, EPA and glucosamine/chondroitin).
-Nutrients good for OCD/bipolar types (I have generally very good mental health but lean to this side of the spectrum): NAC, low dose lithium, melatonin.
-Anti inflammatory (also generally helpful for brain function): Turmeric/black pepper, Black cumin seed oil, NAC, probably most others to some extent.
-General cognitive function: Panex Ginseng, deprenyl, black tea, green tea.

I have refined it according to what works well for me. About me:
-26 year old male
-Neuroscience PhD student
-High level of exercise* (aerobic running/biking, bouldering, weight lifting, various forms of yoga). Generally in good shape, raced a half ironman last year (probably lost a year off my life with that one).
-Vegetarian diet (not vegan), average 14-16 hour daily fast (I skip breakfast), high vegetable intake, I try to not eat much carbs except in a window a few hours around dinner, avoid most sugar.*
-Daily brief meditation practice*, prioritize spiritual life, consciously avoid stressful or distracting media.
-Personality: Generally relaxed, introverted but often social, low stress, optimistic, sometimes leaning to the hypomanic/OCD spectrum if I don't watch my mental/physical health.
-I have several mutations according to my 23andme results which influence this regimen. These include: TNF-alpha (increased function SNP), glycine transporter mutation (reduced glycine uptake), homozygous SOD2 mutation (reduced SOD2 activity, justifies more mitochondrial antioxidants in my mind), homozygous MTHFR (folate receptor mutation; can result in increased homocysteine), many DRD2 dopamine receptor SNP's, 1 APOE epsilon4 allele (slightly increased alzheimers risk). This may seem like a lot but I don't worry too much; even the homozygous combos are not uncommon in the healthy population.

*exercise, diet and mindfulness training are easily more important than all the supplements in this stack combined.

Specific experiences:
-NAC: improved mental clarity, relaxation and slight tiredness. Reduced intestinal inflammation/muscle soreness.
-low dose lithium: improved mental evenness.
-tea, ginseng: enhanced focus, good for working.
-melatonin: Slightly better sleep, more daytime wakefulness.
-raloxifene: Somewhat reduced anxiety and improved general mindfulness (may be placebo).
-The rest I think are cumulatively very beneficial but I don't feel confident that I actively notice anything more than a placebo effect.

Specific reasons for some things:
-raloxifene I haven't seen much on here, but it is a mostly side effect free. non-feminizing SERM with nothing but positive effects on a variety of physiological functions in men and women, and I'm hoping it helps me close the gender lifespan gap.
-deprenyl, along with being one of the best life extension compounds known for awhile, also enhances dopamine function in a way which is beneficial given my poor DRD2 genotype. Also, I have a family history of Parkinson's.
-dutasteride: I don't want to lose my hair or get prostate cancer, and DHT seems to mediate a lot of the negative effects of testosterone including fibrosis from papers I've read. Plus, I don't get side effects on the relatively low dose.
-apigenin: As a CD38 inhibitor it may have more of an effect on NAD+ levels than NR (and is much cheaper).
-I try to take things in the least processed version sensible (dried parsley for apigenin, for example).

Everything I take adds up to less than $800 per year (less than $2.50 per day).

Some things which have not worked well for me:
-low-dose aspirin: Bad stomach problems.
-BCAA's: Kidney pain
-Myoinisitol: Increased manic thoughts for a few hours.
-Hi-Maize: Lots of flatulence.

Some things which I would take at 40 pending further good safety and efficacy results/availability:
-weekly rapamycin or rapalogue
-Nicotinamide Riboside
-pterostilbene
-Epitalon
-SKQ1
-C60
-SS-31
-MK677
-Whichever senescent cell removal treatment proves itself best in the next 10 years.
-Sam-E if I have high homocysteine levels (based off of MTHFR mutation).
-Some cardiovascular polypill if my doctor recommended it, but I doubt it given that I eat well/ excercise.

Please, input much appreciated, or PM me if curious about something. I'm not 100% sure if I should be taking these with more food.

Some references:
-Check selfhacked article with references for most supplements here.
-Raloxifene:
-brain: https://www.ncbi.nlm...cles/PMC149792/
-prostate cancer: https://www.ncbi.nlm...pubmed/12097269
-cardiovascular (disputed): https://www.ncbi.nlm...pubmed/11314601
-skin: https://www.ncbi.nlm...les/PMC2685269/
-bones: http://www.webmd.com...is/guide/serms
-don't take raloxifene if you have blood clotting/DVT issues.
-dutasteride:
-hair loss: https://www.ncbi.nlm...pubmed/24411083
-prostate cancer: http://www.nejm.org/...08127#t=article (can reduce detection of early grade tumors via PSA screening though).
-all cause mortality: https://www.ncbi.nlm...pubmed/24628549
-relaxin/flexibility: https://www.ncbi.nlm...es/PMC3975417/
-DHT has positive effects too, so I take a low dose. Finasteride is a less powerful alternative.

Ingredient Dosage Frequency Administration
raloxifene 60 mg Daily morning
dutasteride 0.5 mg Twice a week morning
deprenyl 5mg mg Daily morning
Black Cumin Seed Oil ~2 ml Daily morning
MCT oil ~5 ml Daily morning
Olive Oil ~5 ml Daily morning
Turmeric 1/2 teaspoon Daily morning
Black Pepper 1/8 teaspoon Daily morning
Ashwangandha 1/3 teaspoon Daily morning
Dried Parsely (apigenin) 1 teaspoon Daily morning
Bacopa 1/3 teaspoon Daily morning
Green Lipped Mussle 1 pill(s) Daily morning
ALCAR 500 mg Daily No instructions provided.
Carnosine 500 mg Daily No instructions provided.
NAC 600 mg Daily with meal/evening (may try twice daily)
Lithium Orotate 5 mg Daily morning
PQQ 20 mg Twice a week morning. Would take daily but it's expensive so I'll wait.
Glycine 3-5 gram Daily with meal/evening
Methyl B12 1 mg Daily morning
Ubiquinol 100 mg Twice a week with meal/evening
Melatonin 300 µg Daily Before bed


Photo
McSchwangstasis
May 20 2017 03:56 PM

Okay 05/20/2017 edit, removed dutasteride due to negative effects on alloprogenalone.