8 replies to this topic

[haga11az]

I've been looking around for a few athletic powder blends to help give me an edge in my kickboxing workout regimen. One of the independent supplements I am taking is Rhodiola Rosea (625 mg w/ 0.8% rosavins), by Planetary Formulas.

So anyway, in one of these products, which I am thinking about puchasing, contains 7-Keto DHEA. I am understanding that 7-Keto is basically a form of DHEA that does not convert to androgens. However, this claim also seems to be illegitimate, as it is always pushed by its advocates, and that's not to mention that there is a patent on this compound (is that correct?).

I am only 20 years old, so I don't want to be messing around with potientially harmful hormones!

I will browse some more and try to find the exact brand and ingredients of this product. Someone told me that a lot of the famous UFC fighters endorse this product as well.

[Mind]

Check Here and here

[nihilist]

magnesium is very likely to be low as well.

[John Schloendorn]

Does anyone know how 7-keto DHEA is made in vivo?

[haga11az]

wait uuummmmmm

what do Zinc and Magnesium have anything to do with 7-Keto DHEA?

I'm not looking to boost my testosterone level... in fact, i don't want to mess with anything that directly messes with hormones, since i'm still relatively young.

[dimjimm]

Title: Safety and Endocrine Effects of 3-Acetyl-7-Oxo DHEA (7-Keto DHEA)
Author: MH Davidson, CE Weeks, H Lardy, K Maki, D Umporowicz
Source: FASEB Jrnl. 1998; 12(5):A4429.

Abstract:
Supplemental dehydroepiandosterone (DHEA) has been postulated to have beneficial effects on heart disease, immune function and well-being. However, conversion of DHEA to sex hormones may cause unwanted side effects. 7-Keto-DHEA is a naturally occurring metabolite which has DHEA activity, but is not converted to sex hormones in vivo. The present study examined the effects of 7-keto-DHEA on several endocrine and safety parameters in healthy adult men (18-49 years of age). 7-Keto-DHEA (n=18) or placebo (n=6) were administered for 8 weeks. The 7-keto-DHEA dose was increased weekly to a maximum of 100 mg bid during the final 4 weeks of treatment. Levels of the hormones measured did not differ between groups (p>0.10) at baseline or during treatment. End-of-trial levels of dihydrotestosterone, estradiol, cortisol and insulin were not different from baseline values (p>0.10). A small reduction in total testosterone [601 ± 142 (SD) vs. 554 ± 149 ng/dL, p<0.01] and a small, clinically insignificant, increase in free testosterone [27 ± 5 vs. 31 ± 8 pg/mL, p<0.01] were observed among men receiving, 7-keto-DHEA. All hormone levels were within normal limits. This study shows that 7-keto-DHEA is well-tolerated at doses up to 200 mg/d and does not produce clinically important sex hormone changes in healthy men.

[Hedrock]

Does anyone know how 7-keto DHEA is made in vivo?

Hi John,

I'm so glad you ask:

In my understanding the path is the following:


DHEA
|
| cytochrome CYP7B1
|
V
7α-hydroxy-DHEA
|
| Oxidation balance (non-encymatic)
|
V
7-oxo-DHEA (= 7-keto-DHEA)
|
| 11β-HSD1
|
V
7α-hydroxy-DHEA
and
7β-hydroxy-DHEA

The result will be lots of amounts of 7β-hydroxy-DHEA, because it's the dead end.

7α-hydroxy-DHEA will reconvert to 7-oxo-DHEA and then again 7α-hydroxy-DHEA and 7β-hydroxy-DHEA.

Link

Just an idea:

Suppress the activity of 11β-HSD1 (e.g (3-(1-adamantyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine Link for suppression or Magnolol Link to magnolol)

Increase the activity of CYP7B1

Then you will have lots of natural 7-keto-DHEA (=7-oxo-DEA)!

Edited by Hedrock, 25 March 2010 - 09:45 PM.