22 replies to this topic

[jackinbox]

It’s terrible how long it take to a drug to hit the market. When do you expect an ampakine to be available? If a really effective smart drug was discovered, would the defence department take over it and keep it secret? Could it be available on black market?

[fast turtle]

Black market? Why don't you just call a chemical supplier and do a custom synth? Plenty upon plenty do. Might run you about $500 a gram and less in bulk but you'll get your product. There's not much demand for an experimental untested/unproven psychostimulant, not enough to produce gigantic amounts of it anyway.

[jackinbox]

500$ a gram: The dosage of CX717 for ADHD is around 1000 mg/day. 500$*30 days = 15000$ per month.... I think I will wait until it hits the market!

[doug123]

Sketchy. I'd wait until they have some human data indicating safety and effectiveness.

[paul]

The FDA halted clinical trials in April. Although the hold was released in October, restrictions are still in place which prevent testing at the level needed to have its memory enhancing effects. Cortex are doing more toxicity to attempt to remove these restrictions but the whole fiasco has cost the company loads (Share price has fallen from $5.60 to $1.60) and slowed thing right down. They have got a number of ampakines in the pipeline but dont expect to see one on the market for perhaps another 5 years.

[doug123]

The FDA halted clinical trials in April. Although the hold was released in October, restrictions are still in place which prevent testing at the level needed to have its memory enhancing effects. Cortex are doing more toxicity to attempt to remove these restrictions but the whole fiasco has cost the company loads (Share price has fallen from $5.60 to $1.60) and slowed thing right down. They have got a number of ampakines in the pipeline but dont expect to see one on the market for perhaps another 5 years.

Hey Paul, I hit up one of your posts recently here...

How is pharmacy school treating you?

[Agarikon]

I just read a front page story in the L.A. Times covering the discovery and amazing promise of Ampakines. How come there is only one Ampakine available to us (provigil) and why is it approved for so few conditions?

[labpv]

We are a gruop of italian cellular neurophysiologists involved since years in research on glutamatergic transmission and plasticity. We would be interested in testing the effect of Ampakines in cerebellar preparation in vitro but till now we haven't found a commercial site for purchasing Ampakines.
Could you please help us?
Please contact me at andreflieshigh@tiscali.it

Dipartimento di Scienze Fisologiche Farmacologiche e Molecolari
Univerity of Pavia
www.unipv.it/dsffcm/pagine/labs/dangelo/dangelo.html

[bob_d]

We are a gruop of italian cellular neurophysiologists involved since years in research on glutamatergic transmission and plasticity. We would be interested in testing the effect of Ampakines in cerebellar preparation in vitro but till now we haven't found a commercial site for purchasing Ampakines.
Could you please help us?
Please contact me at andreflieshigh@tiscali.it

Dipartimento di Scienze Fisologiche Farmacologiche e Molecolari
Univerity of Pavia
www.unipv.it/dsffcm/pagine/labs/dangelo/dangelo.html

why do you need help? you will never get cx 717 until cortex gives it to you or has it's formula released, while it looks like cx 516 can be ordered through several suppliers. even if they don't have it at stock(which most probably will be the case), you could still choose to go the road of custom synthesis. so i don't see your problem.

[neuroenhanced]

I just read a front page story in the  L.A. Times covering the discovery and amazing promise of Ampakines.    How come there is only one Ampakine available to us (provigil) and why is it approved for so few conditions?

Provigil is not an ampakine it's an addictive drug.

Aniracetam and Idebenone are ampakines.

[cmorera]

I just read a front page story in the  L.A. Times covering the discovery and amazing promise of Ampakines.    How come there is only one Ampakine available to us (provigil) and why is it approved for so few conditions?

THE DRUGS
The U.S. Food and Drug Administration frowns on the idea of pharmacological enhancement – drugs intended not to cure, but to augment. But the FDA’s position may quickly seem outdated, according to neuroscientists who argue that drugs intended for aging Baby Boomers fearful of Alzheimer’s and dementia will inevitably find their way into younger users’ medicine cabinets (that’s why they’re called “lifestyle drugs!”). But that’s not necessarily a bad thing, according to University of California at Irvine neuroscientist Gary Lynch.

Lynch is developing a class of drugs called ampakines, which bind to receptors in the brain and boost neurotransmitters, producing an elongated attention span and alert state without (apparently) any side effects. You’ve probably heard of Provigil (also called Modafinil), which was originally intended for narcoleptics. Provigil was scooped up by the military and some go-getter business/student types because it “cures” the brain of sleep deprivation. With Provigil, reportedly, you feel just as alert on, say, five hours of sleep as you would on eight. Provigil users have described having a preternatural ability to concentrate and get work done. While Provigil isn’t technically an ampakine, it’s in a related class and gives us a glimpse of what we can expect from future pharmaceuticals. Last year, Provigil’s maker, Cephalon Labs, filed for FDA approval of a similar drug called Nuvigil, along with Sparlon, a drug for treatment of attention deficit disorder.

The problem is, nobody really understands exactly how these drugs work. They modify neurological processes, somehow, making the brain’s receptors more or less, well, receptive. The murky mechanics behind lifestyle drugs raise all sorts of ethical questions. Do we really want to tinker with our minds – the very things that make us us? Will altering our brains change what it means to be human?

Arthur Caplan, a bioethicist at the University of Pennsylvania in Philadelpia, doesn’t think so. “Stimulating your brain with a reminder on a Blackberry doesn’t seem that different to me from stimulating your brain with a drug,” Caplan told New Scientist magazine.

Wait, so a Blackberry can stimulate your brain? Will that make us smarter? If only someone had said so at the beginning…

this may help.

[jackinbox]

I just read a front page story in the  L.A. Times covering the discovery and amazing promise of Ampakines.    How come there is only one Ampakine available to us (provigil) and why is it approved for so few conditions?

Yeah... they all say that. Admit that you want to boost your grades! Seriously, I wish you the best luck to find the holy grail of nootropics. We definitely need more research on this promising drug. If you get your hand on it, it would be great if you could drop me a message or come back reporting on the forum.

[csrpj]

i'm thinking stuff like IDRA-21 or CX-546

[Ark]

where can one find these?

[Spectre]

I'm interested in finding out where to get them as well.

[Delta Gamma]

The reason people don't try these is because their safety hasn't been fully tested yet and we don't completely understand their mechanisms of action or side effects. However, there was some guy on bluelight.ru that was testing some ampakines on himself, try finding him and seeing what he says about it.

[chrono]

Merged a few threads. Please search before posting a "has anyone tried X" thread, either for the experiences, or a duplicate thread to bump.

There are a few brief experiences scattered around the internet; this is the only one I recall seeing with any appreciable detail. Several others basically said "it made me dizzy."

As Delta Gamma said, very little assurance of safety. And exotic doesn't necessarily mean it's that good. You could get a huge amount of well-tested, probably better nootropics for the price of custom synthesizing something that may be neurotoxic...

[Ampa-omega]

hello! i'm new here and i'm not sure where to ask this question, but i think this is the appropriate spot.

What does anyone think are the best current alternative(s) to ampakines?
(ampa receptor potentiators and desensitization inhibitors or other mechanisms)

what are your thoughts on other ampa active agents instead of racetams, such as cyclothiazide, PEPA, IDRA-21?
other cheap but effective alternatives? which may effect more glutamate receptors.., is their anything you know of?

what has a higher affinity for ampa receptors, oxiracetam or aniracetam?as well pramiracetam?

i read a lot on this forum about aniracetam being a moderately potent ampa receptor modulator,
but what seems surprising to me is that most people noticed a stimulant effect with oxiracetam..

what is the oxiracetam doing in contrast to aniracetam that has this stimuli effect?

-thank you

Edited by Ampa-omega, 19 April 2011 - 07:49 AM.

[Ark]

Irondragon Research Chemicals, used to sell it but they were super expensive and now I believe they are out of business. I'm keen on finding Ampakines, anyone have a new source??? Please Share or PM me.


THANKS!~!~
Ark

Edited by Ark, 19 April 2011 - 07:52 AM.

[Ampa-omega]

Irondragon Research Chemicals, used to sell it but they were super expensive and now I believe they are out of business. I'm keen on finding Ampakines, anyone have a new source??? Please Share or PM me.


THANKS!~!~
Ark

hi mate, do you know of tocris?
also if you can find the chemical structure or name and paste it into google
+ the words order/buy/supplier you may find it available, also in my experience its better to first check pubmed and such sites to find what chemicals are out there and their safety.

[Ark]

Irondragon Research Chemicals, used to sell it but they were super expensive and now I believe they are out of business. I'm keen on finding Ampakines, anyone have a new source??? Please Share or PM me.


THANKS!~!~
Ark

hi mate, do you know of tocris?
also if you can find the chemical structure or name and paste it into google
+ the words order/buy/supplier you may find it available, also in my experience its better to first check pubmed and such sites to find what chemicals are out there and their safety.

Most of the suppliers that i know do only bulk, we'd have to form a group under this avenue for a order.

[Ampa-omega]

that seems to be a more cost effective pathway, But first their would have to be an agreed compound. What is it that you are looking for?

It may be something i may consider, although right now im looking into alternatives to ampakines.

Edited by Ampa-omega, 19 April 2011 - 09:34 AM.

[Ampa-omega]

What does anyone think are the best current alternative(s) to ampakines?
(ampa receptor potentiators and desensitization inhibitors or other mechanisms)

what are your thoughts on other ampa active agents instead of racetams, such as cyclothiazide, PEPA, IDRA-21?
other cheap but effective alternatives? which may effect more glutamate receptors.., is their anything you know of?

what has a higher affinity for ampa receptors, oxiracetam or aniracetam?as well pramiracetam?

i read a lot on this forum about aniracetam being a moderately potent ampa receptor modulator,
but what seems surprising to me is that most people noticed a stimulant effect with oxiracetam..

what is the oxiracetam doing in contrast to aniracetam that has this stimuli effect?

-thank you

also forget to mention Sulfonamides, which may enhance glutamate uptake and alostericly inhibit uptake of gaba

Edited by Ampa-omega, 19 April 2011 - 07:18 PM.