Posted 18 November 2006 - 07:31 PM
I tried Wellbutrin/Zyban/Bupropion 300mg/day a couple of years ago and it seemed to reduce my appetite substantially along with some fairly mild stimulant effects -- AND made it possible for me to kick a bad smoking habit too.
[quote name='http://www.obesityresearch.org/cgi/content/full/10/7/633']Obesity Research 10:633-641 (2002)
© 2002 The North American Association for the Study of Obesity
Bupropion SR Enhances Weight Loss: A 48-Week Double-Blind, Placebo- Controlled Trial
James W. Anderson*, Frank L. Greenway, Ken Fujioka, Kishore M. Gadde, James McKenney¶ and Patrick M. O’Neil**
* Department of Internal Medicine, Veterans Affairs Medical Center, University of Kentucky, Lexington, Kentucky;
Pennington Biomedical Research Center, Baton Rouge, Louisiana;
Nutrition and Metabolic Research Center, Scripps Clinic Del Mar, San Diego, California;
Department of Psychiatry, Duke University Medical Centre, Durham, North Carolina;
¶ National Clinical Research, Inc., Virginia Commonwealth University, Richmond, Virginia; and
** Weight Management Center, Medical University of South Carolina, Charleston, South Carolina.
Address correspondence to Dr. James W. Anderson, Medical Service, 111C, Veterans Affairs Medical Center, Lexington, KY 40511. E-mail: firstname.lastname@example.org
Objective: To critically examine the efficacy of bupropion SR for weight loss.
Research Methods and Procedures: This 24-week multicenter, double-blind, placebo-controlled study randomized obese adults to placebo, bupropion SR 300, or 400 mg/d. Subjects were counseled on energy-restricted diets, meal replacements, and exercise. During a 24-week extension, placebo subjects were randomized to bupropion SR 300 or 400 mg/d in a double-blinded manner.
Results: Of 327 subjects enrolled, 227 completed 24 weeks; 192 completed 48 weeks. Percentage losses of initial body weight for subjects completing 24 weeks were 5.0%, 7.2%, and 10.1% for placebo, bupropion SR 300, and 400 mg/d, respectively. Compared with placebo, net weight losses were 2.2% (p = 0.0468) and 5.1% (p < 0.0001) for bupropion SR 300 and 400 mg/d, respectively. The percentages of subjects who lost 5% of initial body weight were 46%, 59%, and 83% (p vs. placebo < 0.0001) for placebo, bupropion SR 300, and 400 mg/d, respectively; weight losses of 10% were 20%, 33%, and 46% (p vs. placebo = 0.0008) for placebo, bupropion SR 300, and 400 mg/d, respectively. Withdrawals, changes in pulse and blood pressure did not differ significantly from placebo at 24 weeks. Subjects who completed 48 weeks maintained mean losses of initial body weight of 7.5% and 8.6% for bupropion SR 300 and 400 mg/d, respectively.
Discussion: Bupropion SR 300 and 400 mg/d were well-tolerated by obese adults and were associated with a 24-week weight loss of 7.2% and 10.1% and sustained weight losses at 48 weeks. [/quote]
[quote name='http://www.cbsnews.com/stories/2004/02/13/earlyshow/saturday/main600283.shtml']Bupropion is sold under the brand name of Wellbutrin and is an antidepressant. Like some drugs sold specifically to help lose weight, Bupropion makes users feel less hungry. A recent study found that 14 percent of those people who took the drug every day lost about 5 pounds in eight weeks. However, some people experience side effects including anxiety, constipation and nausea.[/quote]
Adderall -- on the other hand -- is a mixture of four amphetamine salts. I don't know if it would be necessary to combine these two drugs. I think the clinical effect of the amphetamines might overpower any effects of Wellbutrin to the point of little or no significance.
[quote name='http://en.wikipedia.org/wiki/Adderall']1/4 Dextro-amphetamine Saccharate
1/4 Dextro-amphetamine Sulfate
1/4 dl-amphetamine Aspartate (racemic amphetamine)
1/4 dl-amphetamine Sulfate (racemic amphetamine)[/quote]
Please report if you try it.