Posted 26 August 2007 - 10:11 AM
The problem with sub-lingual delivery is that resveratrol is only soluble in oil (moderately) and solvents such as ethanol. You need to combine the resveratrol with a carrier such as an edible oil/emulsifier combination or a solvent such as DMSO or alcohol to obtain a significant degree of adsorption. Furthermore the problem with a solvent or oil is compounded by the fact that the quantity of the carrier needed to dissolve a meaningful amount of resveratrol would not be practical to use in a sub-lingual delivery modality.
There are other ways to enhance bio availability and we are currently working on a few. These systems involve taking the particle size down to about 5 microns, dermal patches, botanical additives, lipid particle coatings and one proprietary system that I am not free to discuss here.
In the meantime taking resveratrol after consuming an oily food heps with bio availability. This is not because the resveratrol is dissolved in the oil but because the oil stimulates bile production in your your liver and delivery of this emulsifier to your stomach by the gall bladder. Taking resveratrol in the morning after breakfast may also help since bile levels are highest upon waking and tend to diminish towards evening. James at Biotivia Ltd.