My mother has MS and has been taking low dose naltrexone (LDN) for several years to good effect. I recommended it to her after noticing it was rated the most effective treatment for MS (at the time) at revolutionhealth.com, a site that allows patients to rate various treatments on several indices based on their personal experience. All anecdotal evidence, I know, but there are some suggestive animal studies and theoretical reasons to think it may be effective. It is supposed to work by triggering a hormetic response, blocking opiod receptors briefly while you sleep, which increases their production during the day. Endogenous opiods are important regulators of immune function, and so LDN is thought to have benefit in a number of auto-immune disorders like MS. At the website lowdosenaltrexone.org, you can find the clinical experiences of Dr. Bernard Bihari in his treatment with LDN of patients with diseases ranging from cancer to AIDS to IBS, etc.
I began thinking that perhaps I should take it myself, though I do not have any such disease. In 50mg doses it is used as a prophylactic treatment to prevent relapse in opioid and alcohol addicts and has been tested for safety and is FDA approved for that indication. The dose used in off-label treatment of auto-immune disorders is 3-5mg. At that dose, my thinking was that it is very cheap and probably safe, and might prevent various illnesses as well as improve my mood and energy levels (a reported effect).
I looked online for any references to its use for such a purpose and was surprised to find a patent filed for this use by Dr. Alexander Michalow. Further investigation revealed that Dr. Michalow was giving a presentation at SENS3 on the topic. He didn't mention LDN by name, as there are several other compounds that could be used (such as naloxone), but his hypothesis seems to be that CR works by a hormetic mechanism and that one of the steps in that metabolic cycle could be induced by something like LDN, interfering in the pathway at a point before sirtuins would become activated. I watched the recently posted video of his presentation. He was rushed and didn't do a good job selling his idea, and an attendee practically heckled him.
Still, based on my mother's experience and what I've read, I'm seriously considering taking it. What do you think? Have you ever heard of this? Would you be willing to try it?