Part of this discussion has already occurred in the Resveratrol Effectiveness thread. But where as I have been sick for the past month with one thing or another (Strep, cold, cold, Strep), I have more or less stopped taking it. When taking my rather large dose of resveratrol (2g/day), I notice small acne resembling infections characterized by redness around white center (not acne though), and an affinity for colds. In one since it is comforting to know that the dose that I am taking is effective, but I just can't do it through the winter months. I will also add that though I do not normally drink heavily, the two times that I got strepp were right after wild nights, so you can toss those out. My results are just one data point though.
Here is a study on immune suppression effects of Resv:
Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.
Sharma S, Chopra K, Kulkarni SK, Agrewala JN.
Immunology Laboratory, Institute of Microbial Technology, Chandigarh, India.
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
As to discussing the study, Resveratrol decreases the expression of CD28 (thereby decreasing TCell activation) and CD80 (Further decreasing TCell activation and decreasing survival). Resveratrol also increase the production of IL-10 which inhibits Th1 cytokine production (some of which are instrumental in viral, and tumor response) and suppress the antigen presentation capacity of antigen presenting cells.
Here are some graphs from the full text:
After 72 h of incubation, [3H]-thymidine was added and the cells were harvested 16 h later and radioactivity incorporated was measured.
Yeh, resveratrol crushes those white blood cell signals.
Hmmm... Here is the rest of the article:
So these studies were in vitro so to extract these results to being taken orally in humans is a bit of a jump.
Oddly Resveratrol and Curcummin are anti cancerous despite their immune suppressive qualities; this leads to the option of further increasing mean lifespan by remodulating the immune system to a normal or optimal level.
So as it stands for me, I'm not going to take resveratrol till I'm feeling well again.
Edited by lucid, 29 November 2007 - 04:30 AM.