15 replies to this topic

[Miracle]

anti-aging GenF20 HGH is a Human Growth Hormone releaser that helps replenish your body's lost levels of HGH, im a 17 year old male and i seem to look way older than i am, and have many mood swings, and i was wondering if it would be okay to take this natural supplement, more info can be found here:

www.genf20.com

edit:

I was told  http://www.ghr1000.com/ is better, but check it out for yourself and please let me know.

Edited by Miracle, 06 April 2008 - 09:53 AM.

[balance]

You're only 17.... Hell no.

Stick with a good multivitamin and fish oil combo. Maybe add in some bone building nutrients. Take some l-theanine or l-tyrosine for the mood. In studies people that started supplementing even in old age actually became up to 3.5 years younger biologically. You're way too young right now to start experimenting with growth hormone/variants.

[ajnast4r]

absolutely not.


start eating right, taking a multivitamin/mineral & exercising.

[wayside]

From the ghr1000 website:



I don't know what "Tribulus Terrestris" is, but the rest of it seems pretty tame.


The stuff from genf20.com also seems pretty tame:



I'm not sure what "Pituitary (Anterior) Pwd." is either, sounds yummy though.


My guess is that neither one of these products would do jack-sh** to increase HGH. I'm not alone either:

Review of GHR1000
Review of genf20

[troika]

It is always funny to just blow of something without ever having tried it. Unless you have tried one of these supplements you really can't say for sure if they work or not. In fact a lot of antidepressants for example work for some people and do nothing for others; does that mean that we should stop using anti depressants completely. My point is try ghr1000 or genf20 then decide, both these products come with money back guarantee.

Edited by maxwatt, 16 May 2012 - 11:20 PM.

[luv2increase]

anti-aging GenF20 HGH is a Human Growth Hormone releaser that helps replenish your body's lost levels of HGH, im a 17 year old male and i seem to look way older than i am, and have many mood swings, and i was wondering if it would be okay to take this natural supplement, more info can be found here:

www.genf20.com

edit:

I was told  http://www.ghr1000.com/ is better, but check it out for yourself and please let me know.

Just because you look way older than you are is not an indicator that you HGH levels are low. What in the world eluded you to that?


Have you had your HGH levels tested? You cannot just assume.



HGH is not the sole indicator of aging. There are many many variables. Do your parents look old for their age?

[zoolander]

Hang on a minute....at 17 looking older is an advantage isn't it. You won't have to pay Hobbos in the street three fiddy (god Damn lockness Monster) to buy your booze (get off my lawn).

[Anthony_Loera]

Unless you have something like Laron Syndrome, taking HGH may decrease lifespan.

(at least that is my current take on it...)

A

[wayside]

It is always funny to just blow of something without ever having tried it. Unless you have tried one of these supplements you really can't say for sure if they work or not. In fact a lot of antidepressants for example work for some people and do nothing for others; does that mean that we should stop using anti depressants completely. My point is try then decide, both these products come with money back guarantee.

Money-back guarantee from some random web-site, that is funny.

Why don't you post some studies that show this junk works?

Edited by maxwatt, 16 May 2012 - 11:21 PM.

[humpty]

I've heard of genf20 and it seems like a good deal with some prime ingredients. I found this place called hghlevel.com which lets the customers provide feedback of the supplement. Any one here try it before I commit?

[kismet]

Unless you have something like Laron Syndrome, taking HGH may decrease lifespan.

(at least that is my current take on it...)

A

I am not even sure if that is the case. Evidently Laron syndrome produces signs of "premature aging" and some side-effects related to reduced growth-hormone (signalling).
However, it would contradict the animal data if the syndrome really caused premature aging (ok, it happens, we are not rodents after all), but evidence in humans seems to point in the same direction as the animal data. I recommed the short review by Zvi Laron himself. [1]
People suffering from Laron syndrome can have regular life spans and even live quite longer than the average, but we can't draw any firm conclusions as of yet. Although, I'd be glad if the GH/IGF-1 axis acted similar in mammals for the sake of longevity research.

[1] Mech Ageing Dev. 2005 Feb;126(2):305-7.
Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?
Laron Z.

Edited by kismet, 02 January 2009 - 12:33 AM.

[VampIyer]

OK, now even I will draw attention to the fact that 2 of these posters are new.

Also these products are primarily just amino acids... some of us take EAA, BCAA, or other aminos anyway. There has been some discussion on the effects of arginine + ornithine + glutamine (esp. taken at night) on GH release, but I don't remember any clinically significant results. Still: even at 17 years old... moderately dosed amino acids aren't going to HURT you.

Taking real HGH at this age would be inadvisable.

Edit: Sorry. I noticed that one of the products has Tribulus in it. There might be some hormonal effects from that (tribulus may do nothing for many, but I'm sensitive to all of these products so it's instant gyno fo me) . Other than that, I don't know what the hell Anterior Pituitary powder is going to do. Everything else looks like a harmless waste of money (because you could get the same for less elsewhere I'm sure).

Edited by VampIyer, 02 January 2009 - 01:29 AM.

[kismet]

Other than that, I don't know what the hell Anterior Pituitary powder is going to do.

After our experience with pit-hGH from cadavers (transmitting HIV, CJD, etc) and the huge dangers involved with any (animal) brain tissue (transmission of BSE/CJD and/or other prion diseases) I really hope "Anterior Pituitary powder" is not what I think it is.

Obviously those posters are just spammers or spambots.

Edited by kismet, 03 January 2009 - 03:16 PM.

[Brainbox]

The question is if this study can be extrapolated to humans, but in general, has there been any research that delivers positive proof regarding the use of elevated HGH levels in humans?

Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice.
Bartke A.

Departments of Physiology and Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794-9628, USA. abartke@siumed.edu

Overexpression of heterologous growth hormone (GH) in transgenic mice results in numerous phenotypic effects, including a drastically shortened life span. Early onset of pathological changes in the kidneys, glomerulosclerosis and glomerulonephritis, undoubtedly contributes to and perhaps accounts for reduced longevity of these animals. However, GH-transgenic mice exhibit various symptoms of accelerated aging, including increased astrogliosis, shortened reproductive life span, and early onset of age-related changes in cognitive function, hypothalamic neurotransmitter turnover, and plasma corticosterone levels. The hypothesis that supraphysiological levels of GH can accelerate aging derives indirect support from findings in GH-deficient and GH-resistant mutant mice in which aging is delayed and the life-span is increased and from the reciprocal relationship of body size and longevity within species. Copyright 2003 S. Karger AG, Basel

PMID: 14583653 [PubMed - indexed for MEDLINE]

[kismet]

The question is if this study can be extrapolated to humans, but in general, has there been any research that delivers positive proof regarding the use of elevated HGH levels in humans?

Well, it certainly depends on your definition of "positive". We know what hGH does, it is anabolic, lipolytic and helps regeneration (probably at the cost of increased cancer risk [1]) - if this is your thing, then yes, we have a lot of positive evidence. I think [2] is the original study which started the GH "anti-aging" hype, as expected GH reversed part of the aging phenotype (positive influence on bone mass, adpiose tissue and muscle mass), but testosterone replacement or resistane training should do the same. We have thousands of accounts of AAS and hGH abuse among athletes,  yes it does work.
However, I am still of the opinion (but without direct proof) that high GH levels contribute to human aging the same way they do in rodents - just slightly less. So far the data on Laron dwarfism [3] does not contradict the theory, but I guess that low GH levels offer less benefits and have more side-effects than in rodents. The GH/IGF-1 axis seems to act similar in mammals anyway [4]. Most rodents die from cancer, because they are very susceptible and even very small cancers can kill them, so a lack of GH - slowing down cancerous growth - would be expected to influence their lifespan more dramatically than in humans. Still many cenetarians have cancers at death and/or die due to cancer (and many more die probably from amyloidosis) hence it should help. Epidemiologic data seems to support the insulin/IGF-1 connection with cancer.
So medium to low GH levels might be the best for life extension purposes, avoiding Laron-like changes in phenotype, but inhibiting tissue growth. Sarcopenia, osteoporosis and thining of the skin should be treated with other interventions then the net effect of low GH levels would be positive.

EDIT: exchanged the paper by Laron for a newer one with free access

[1] Antitumorigenic actions of growth hormone-releasing hormone antagonists 
Rhonda D. Kineman
http://www.pnas.org/...t/97/2/532.full
[2] Effects of human growth hormone in men over 60 years old
D Rudman, AG Feller, HS Nagraj, GA Gergans, PY Lalitha, AF Goldberg, RA Schlenker, L Cohn, IW Rudman, and DE Mattson http://content.nejm....nt/full/323/1/1
[3] The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
http://hormones.gr/p...ew.php?c_id=204
[4]  Growth Horm IGF Res. 2008 Dec;18(6):455-71. Epub 2008 Aug 16.
Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models.
Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ.

Edited by kismet, 05 January 2009 - 02:21 PM.

[ajnast4r]

Hang on a minute....at 17 looking older is an advantage isn't it. You won't have to pay Hobbos in the street three fiddy (god Damn lockness Monster) to buy your booze (get off my lawn).