I would like to compare notes with other users here who might be getting negative effects from CoQ10 or MitoQ. What I am discovering with both of these supplements is that I get some inappropriate kind of excitatory effect and the symptoms of this are wild and inappropriate changes in my pulse, and separately some kind of brain fog. I'm currently suffering from some kind of mitochondrial injury that has destroyed most of my aerobic metabolism. So my VO2Max numbers are lowest-data-point in a population study of 200+ people, including both sedentary and endurance trained groups. Whatever the nature of the injury is, CoQ10 and MitoQ appear to aggravate the condition rather than improve it.
The fact that pulse runs around for a day after taking either CoQ10 or MitoQ to me suggests a possible adrenalin response. And my serum adrenalin (and pituitary hormone) numbers have all been testing high. They have excluded ACTH tumor, and have likely excluded adrenalin stimulating tumors, so the high adrenalin may be a response to supplements.
I am interested in hearing from other users whether you have these kinds of issues after taking CoQ10 or MitoQ:
* pulse going higher
* blood pressure swings higher
* blood glucose readings both pre and postprandial that go higher
Do you get these symptoms, all of which might suggest an adrenalin response, for about a day or two after you supplement CoQ10 or MitoQ? And very importantly do the symptoms immediately clear after a few days if you stop supplementing?
Any other symptoms? I note one user in this thread reporting lower blood pressure when taking ubiquinol but not ubiquinone. CoQ10 appears to be a powerful mediator of metabolism in some of us, with some possibly non trivial effects going on behind the scenes.
We could prove adrenalin by doing a 24 hour urine catecholamines test before and after a period of supplementation. That's a hassle and finding a doctor willing to cooperate will be hard for some of us. I would first like to survey who else is having these effects. Another user in the MitoQ thread is reporting the suspicious jumping pulse result, but apparently she is not on the site very often because she has not responded to me.
If any of you who get symptoms have 23andme testing done, what is the value on your MAO A RS6323 SNP? I am a male with T, so that is equivalent to TT for a female. T means you do not metabolize adrenalin efficiently. So the interesting hypothesis (presently without an ounce of proof) is maybe many people are getting the adrenalin surge, but people without the risk allele on RS6323 simply metabolize it away so quickly they do not get lasting symptoms.
Edited by pone11, 19 March 2015 - 10:40 PM.