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Coenzyme Q10 May Shorten Your Life!

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#31 John2009

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Posted 21 May 2013 - 02:21 AM

Some info I found on coQ10 and life extension

I found this article about life extension and coq10 in old mice...

The article and other info can be found on this site...

More research articles here

This is the non profit international coenzyme q10 foundation...

Article about studies suggesting conflicting conclusions

I found reference to a couple of studies here that my provide more information....
Coles, S., & Harris, S. B. Co-enzyme Q-10 and life extension. In: Advances in Anti-Aging Medicine. Volume 1. Dr. Ronald M. Klatz (editor), 1996

Linnane, A. 9th International Symposium on Biomedical and Clinical Aspects of Coenzyme Q10. Ancona, Italy, 1996. Reported In: Life Extension. 2(11):42, 1996.

Edited by John2009, 21 May 2013 - 02:35 AM.

#32 John2009

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Posted 24 May 2013 - 01:24 AM

I know LEF has CoQ10 on their top ten list, but are most longecity forum members here using coQ10 ? Is this a worthwhile supplement for someone over 40 ? If so, what is a good daily dose ?

LEF two page List of 43 study citations:
https://www.lef.org/...ey=coenzyme q10


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#33 jly1986

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Posted 24 May 2013 - 11:40 AM

CoQ10 always makes me feel really tired when I take it, which was always funny to me, because it's marketed as an energy-boosting supplement. I get so fatigued that I stop taking it and then after a couple days, I feel back to normal.

#34 Kevnzworld

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Posted 24 May 2013 - 11:29 PM

CoQ10 ( especially the ubiquinol form ) is good for aging people with heart conditions, especially early CHF. It helped my father the last few years of his life. It is also good for statin users to supplement given that statins reduce the amount of CoQ10 the liver produces.
Those that take higher doses of PUFA's ( fish oil ) can also benefit because CoQ10 reduces levels of lipid peroxidation.
I take 200 mg daily.
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#35 rwac

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Posted 25 May 2013 - 02:40 AM

CoQ10 always makes me feel really tired when I take it, which was always funny to me, because it's marketed as an energy-boosting supplement. I get so fatigued that I stop taking it and then after a couple days, I feel back to normal.

Yes, this is exactly what I experience. CoQ10 promotes fat burning which definitely can affect people negatively. Fat is not as good a food for the brain as glucose.
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#36 nameless

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Posted 25 May 2013 - 04:39 AM

I wonder if some of the people who notice fatigue from CoQ10 or Ubiquinol measured their blood pressures?

I noticed Ubiquinol at 200mg seems to lower my blood pressure a bit (around 10 pts or so)... which is actually a negative in my case, as sometimes it gets a bit too low. But I do recall some reports of people stating fatigue when switching from CoQ10 to Ubilquinol...and then I wondered if it's possible the fatigue is simply related to blood pressure.

Not that it matters, as if you get tired from it regardless of cause, it's doubtful it's worth taking. If a person has high blood pressure issues, it could be something to consider though.

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#37 thenaturalstep

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Posted 10 February 2014 - 06:46 PM

I am 32 yeas old and i am thinking about taking 30 mg Q10 each day. Of course when i read something like this it makes me think. But this was 2008, and it seemed to be a controversial opinion even then. I checked wikipedia and found nothing about decreasing life span, instead it seemed to improve your lifespan:


One study demonstrated that low dosages of CoQ10 reduce oxidation and DNA double-strand breaks, and a combination of a diet rich in polyunsaturated fatty acids and CoQ10 supplementation leads to a longer lifespan in rats.[68] Coles and Harris demonstrated an extension in the lifespan of rats when they were given CoQ10 supplementation.[69] But multiple studies have since found no increase in lifespan or decrease in aging in mice and rats supplemented with CoQ10.[70][71][72][73] Another study demonstrated that CoQ10 extends the lifespan of C. elegans (nematode).[74]

A 2013 study that characterizes an aspect of aging due to a nucleic communication breakdown with mitochondria inherently postulates a novel approach for CoQ10 as an anti-aging factor, being that it facilitates mitochondria in energy production, thereby reversing the aging effect resulting from nutrient-deprived mitochondria, likened to the findings of non-functioning mitochondria as described in the study.[75]

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