9 replies to this topic

[SWALK]

Hey, I may need a little help.

First, some back ground.
I have been taking Ecstacy (X) for about 9 months now, I have quit, and never intend to touch the stuff again, however.

X acts on the brain by forcing large amounts of seritonin into the synaps, thus trigering the whole euphoria thing, not bad in itself, but it also messes with the seritonin reuptake transporers in such a way that they take up more than seritonin, to be precise, they take up dopamine into the seritonin cells, this is bad, due to the fact that the dopamine then gets broken down in a cell that is not prepaired to deal with it, causing oxidisation and the production of some nasty chemicals which, to put a long story short, causes the seritonin brain cells to, well, shrivel up.

not good when you consider that seritonin is a happynes chemical.

so, after that, i am looking for something to help repair my brain, if you could please skip the derogitory remarks on my part, i know X is stupid and pointless now, i just want to get better and recover from the damage i have done myself.

any sugestions would be welcome, i will be watching this post, thanks in advance.

Joshua.

[ajnast4r]

what type of symptoms are you having?

i abused mdma fairly regularly when i was younger, and was left with some pretty nasty side effects. the two things that made the biggest difference for me was 1) daily meditation and 2) st johns wort. SJW caused a 100% remission of the sporatic bouts of depression i was having which was [i believe] due to mdma abuse.

i just wrote a whole big post about st johns wort, how it effected me, proper usage & finding a good medical grade extract(theres a big difference between the different extracts). look for my posts in this thread(specifically this and this), and feel free to PM me any time:

CNS Drugs. 2003;17(8):539-62.

Extracts of Hypericum perforatum L. (St John's wort) are now successfully competing for status as a standard antidepressant therapy. Because of this, great effort has been devoted to identifying the active antidepressant compounds in the extract. From a phytochemical point of view, St John's wort is one of the best-investigated medicinal plants. A series of bioactive compounds has been detected in the crude material, namely flavonol derivatives, biflavones, proanthocyanidines, xanthones, phloroglucinols and naphthodianthrones. Although St John's wort has been subjected to extensive scientific studies in the last decade, there are still many open questions about its pharmacology and mechanism of action. Initial biochemical studies reported that St John's wort is only a weak inhibitor of monoamine oxidase-A and -B activity but that it inhibits the synaptosomal uptake of serotonin, dopamine and noradrenaline (norepinephrine) with approximately equal affinity. However, other in vitro binding assays carried out using St John's wort extract demonstrated significant affinity for adenosine, GABA(A), GABA(B) and glutamate receptors. In vivo St John's wort extract leads to a downregulation of beta-adrenergic receptors and an upregulation of serotonin 5-HT(2) receptors in the rat frontal cortex and causes changes in neurotransmitter concentrations in brain areas that are implicated in depression. In studies using the rat forced swimming test, an animal model of depression, St John's wort extracts induced a significant reduction of immobility. In other experimental models of depression, including acute and chronic forms of escape deficit induced by stressors, St John's wort extract was shown to protect rats from the consequences of unavoidable stress. Recent neuroendocrine studies suggest that St John's wort is involved in the regulation of genes that control hypothalamic-pituitary-adrenal axis function. With regard to the antidepressant effects of St John's wort extract, many of the pharmacological activities appear to be attributable to the naphthodianthrone hypericin, the phloroglucinol derivative hyperforin and several flavonoids. This review integrates new findings of possible mechanisms that may underlie the antidepressant action of St John's wort and its active constituents with a large body of existing literature.

the parts i highlighted, specifically underlined, are what would be significant to someone who has abused mdma... sjw can actually help to repair damaged areas of the brain

Edited by ajnast4r, 28 June 2008 - 01:01 PM.

[zoolander]

joshua, good move reaching out to people. You're on the right track.

You're going to need to give it about 12 months off any recreational drug for things to level out again. Please be patient.

[Rags847]

Excellent article on ecstasy here on the Narconon website:
http://www.addiction...FAQ-ecstasy.htm

Can't recommend this product specifically, but it gives an idea of various repairing avenues to look into: http://www.recoverye.../kits/adve.html

Healing and repairing your brain is a serious and excellent undertaking. You should research it thoroughly and seek an expert doctor in this field. Finding a doctor that is really an expert in healing the brain specifically from this drug is an expense worth every penny.

Best of luck to you.


http://www.drug-reha...ugs/ecstasy.php
http://www.ecstasy-effects.com/

Edited by Rags847, 28 June 2008 - 03:21 PM.

[SWALK]

In response to ajnast4r asking what my symptoms are, theres the contant depresson, not just talking about bouts or anything like that, constant. that of course is accompanied by a feeling of hopelessness and sometimes nausia.
but the worst is that now i am constantly having minor hlucinations, for example, my bred bin is always covered in neon writing, the walls are rainbow coloured and sometimes other weird things happen. its scary as hell and im not shure it will ever be fixed.
but of course i wouldnt be panicking as much if my brain wasnt messed up, as theres no seritonin, but thats just a circular argument.
thanks for the hellp and advice, reading it now, hopefully i can find something.
thanks
Joshua

[medievil]

Hey, I may need a little help.

First, some back ground.
I have been taking Ecstacy (X) for about 9 months now, I have quit, and never intend to touch the stuff again, however.

X acts on the brain by forcing large amounts of seritonin into the synaps, thus trigering the whole euphoria thing, not bad in itself, but it also messes with the seritonin reuptake transporers in such a way that they take up more than seritonin, to be precise, they take up dopamine into the seritonin cells, this is bad, due to the fact that the dopamine then gets broken down in a cell that is not prepaired to deal with it, causing oxidisation and the production of some nasty chemicals which, to put a long story short, causes the seritonin brain cells to, well, shrivel up.

not good when you consider that seritonin is a happynes chemical.

so, after that, i am looking for something to help repair my brain, if you could please skip the derogitory remarks on my part, i know X is stupid and pointless now, i just want to get better and recover from the damage i have done myself.

any sugestions would be welcome, i will be watching this post, thanks in advance.

Joshua.

thats a very old theory that had been disproven, also i would read thedea.org, there is no evidence that there is any neurotoxitcy occuring in humans, neurotoxiticy has been linked to body temp in animals

it does however make serotonin less sensitive, i would experiment with inositol or sint johns worth (used before to bring te magic back)

what type of symptoms are you having?

i abused mdma fairly regularly when i was younger, and was left with some pretty nasty side effects. the two things that made the biggest difference for me was 1) daily meditation and 2) st johns wort. SJW caused a 100% remission of the sporatic bouts of depression i was having which was [i believe] due to mdma abuse.

i just wrote a whole big post about st johns wort, how it effected me, proper usage & finding a good medical grade extract(theres a big difference between the different extracts). look for my posts in this thread(specifically this and this), and feel free to PM me any time:

CNS Drugs. 2003;17(8):539-62.

Extracts of Hypericum perforatum L. (St John's wort) are now successfully competing for status as a standard antidepressant therapy. Because of this, great effort has been devoted to identifying the active antidepressant compounds in the extract. From a phytochemical point of view, St John's wort is one of the best-investigated medicinal plants. A series of bioactive compounds has been detected in the crude material, namely flavonol derivatives, biflavones, proanthocyanidines, xanthones, phloroglucinols and naphthodianthrones. Although St John's wort has been subjected to extensive scientific studies in the last decade, there are still many open questions about its pharmacology and mechanism of action. Initial biochemical studies reported that St John's wort is only a weak inhibitor of monoamine oxidase-A and -B activity but that it inhibits the synaptosomal uptake of serotonin, dopamine and noradrenaline (norepinephrine) with approximately equal affinity. However, other in vitro binding assays carried out using St John's wort extract demonstrated significant affinity for adenosine, GABA(A), GABA(B) and glutamate receptors. In vivo St John's wort extract leads to a downregulation of beta-adrenergic receptors and an upregulation of serotonin 5-HT(2) receptors in the rat frontal cortex and causes changes in neurotransmitter concentrations in brain areas that are implicated in depression. In studies using the rat forced swimming test, an animal model of depression, St John's wort extracts induced a significant reduction of immobility. In other experimental models of depression, including acute and chronic forms of escape deficit induced by stressors, St John's wort extract was shown to protect rats from the consequences of unavoidable stress. Recent neuroendocrine studies suggest that St John's wort is involved in the regulation of genes that control hypothalamic-pituitary-adrenal axis function. With regard to the antidepressant effects of St John's wort extract, many of the pharmacological activities appear to be attributable to the naphthodianthrone hypericin, the phloroglucinol derivative hyperforin and several flavonoids. This review integrates new findings of possible mechanisms that may underlie the antidepressant action of St John's wort and its active constituents with a large body of existing literature.

the parts i highlighted, specifically underlined, are what would be significant to someone who has abused mdma... sjw can actually help to repair damaged areas of the brain

lols i replied before i have read your post, but yeah there has been more succes with SJW

[meursault]

Exercising regularly and having a good diet are the key to healthy lifestyle and will greatly help with recovery. Try walking/jogging a couple times a week, eat a couple servings of vegetables and fruits daily, and maintain a consistent sleep schedule.

Furthermore, if you are having minor hallucinations, you need to see a doctor. Recovery will most certainly come with time, but it is important to seek medical attention when you cannot function normally even after cessation. Keep to your word to quit and your doctor, family, and friends will be supportive.

Edited by czukles, 29 June 2008 - 07:22 PM.

[ajnast4r]

zoolander and czukles both make extremely important points. you must be patient...it took me about 6 years to get to the point now where i feel i am 100% recovered (although i abused drugs other than mdma, and for quite a bit longer than you... so your recovery may be significantly shorter) and you must exercise, adhere to a good diet & get proper sleep.

the minor visual hallucinations will lessen over the next few years but most likely you will be stuck with them atleast somewhat (trails, breathing, glowing). its not a big deal, and its nothing to worry or get anxious about imo. you'll get used to it.

Edited by ajnast4r, 29 June 2008 - 11:19 PM.

[ortcloud]

Exercising regularly and having a good diet are the key to healthy lifestyle and will greatly help with recovery. Try walking/jogging a couple times a week, eat a couple servings of vegetables and fruits daily, and maintain a consistent sleep schedule.

Furthermore, if you are having minor hallucinations, you need to see a doctor. Recovery will most certainly come with time, but it is important to seek medical attention when you cannot function normally even after cessation. Keep to your word to quit and your doctor, family, and friends will be supportive.

and what would a doctor do ?

[meursault]

Exercising regularly and having a good diet are the key to healthy lifestyle and will greatly help with recovery. Try walking/jogging a couple times a week, eat a couple servings of vegetables and fruits daily, and maintain a consistent sleep schedule.

Furthermore, if you are having minor hallucinations, you need to see a doctor. Recovery will most certainly come with time, but it is important to seek medical attention when you cannot function normally even after cessation. Keep to your word to quit and your doctor, family, and friends will be supportive.

and what would a doctor do ?

I'd imagine a doctor could refer him to a neurologist. I don't know, but I think it would be poor judgment to tell someone that is currently hallucinating to just "stick it out" if it is disturbing them during the day.