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indiscriminate activation of SIRT1 might lead to cancer?


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#1 Beckham

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Posted 30 June 2008 - 10:59 PM


I found this on ouroboros blog.

Does this mean that it isn't safe for women to take daily
dose of Resveratrol?

Your thoughts please.
Thanks

I am currently wondering whether recent findings that indiscriminate activation of SIRT1 might lead to cancer (e.g., when DBC1 is deleted) will temper the enthusiasm for these compounds.

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perhaps DBC1 is particularly important in epithelial populations that, like the breast, lie dormant for much of the lifespan but possess the latent ability to proliferate rapidly in response to hormones — in cells like these, it makes sense to have a relatively "hair-trigger" apoptotic response to potentially carcinogenic insults.


http://ouroboros.wor...laxosmithkline/




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