Adrafinil is metabolized in vivo to Modafinil... their mechanisms of action are essentially the same at that point.
The key difference is that you have to wait ~hour till Adrafinil is metabolized. The hour half-life of Adrafinil is irrelevant to the ~twelve hour half life of Modafinil. Once metabolized into Modafinil I'd wager the half life tendencies are the same in metabolized Adrafinil as in Modafinil stand-alone.
The other key difference is price, hahaha.
Main diff, one is legal, while the other technically not unless by doctor
1. I think it stands to reason for Mod to be more efficient, potent even. What is AUC??
If by efficient you mean you get the desired effects faster then I guess you're right.
3. I'm sure there're side effects.
Other than those one would normally get with Modafinil stand-alone, what other side effects can you point out other than traces of sulfur once metabolized--sulfur is harmless. I'm not saying there's no side effects, I'm just curious about further distinctions between the two drugs.
4. I think adrafinil taxes the liver a bit, but the liver toxicity is low compared to other toxins
Over prolonged periods of time, yes. Hey, sounds like alcohol! You shouldn't be using stimulants all the time anyways (unless you have ADHD, and yes I'm aware some believe that is a dubious claim). Just like alcohol, moderation is important, especially considering the many unknowns involving using these many of these drugs as nootropics in the long run.
Edited by Duke, 18 January 2009 - 02:07 AM.