I'm a huge Picamilon enthusiast, but I think some of you guys are straight up INSANE with the dosages you are listing.
You're getting pills with 150mg each ??? Well my little "drug manual" leaflet that comes in the box with the pills says around 300mg is about the maximum dose you wanna take in 24 hours, with about 200mg prescribed for "alcohol encephalopathy" (sp.?) which is no joke, if you've ever seen anyone suffer from that.
Around here they're sold in 20 and 50 mg plastic bottles. I'd never go over 200-250 mg for the entire day, because that just creates all those side effects like sleepless nights, being manic etc. And you guys are taking it WITH over a gram of Piracetam!?!?!?!?! And you don't get sent to a padded room? I broke a toilet stall at my work to pieces after combining Picamilon with some other nootropics. Gave it a hell of a kick too, just uncontrollable anger.
And what's with the comments about "gives you a stimulating feeling the entire day" when Picamilon's half-life in my instruction manual (looked it up in separate med books too) is listed at a half an hour?? If anything, it produces a short-term feeling of being both very relaxed but still able to function well, but it wears off in just over an hour, and there are NO effects past the 2-hour mark unless you take more. Of course it does accumulate in the brain tissues over time, but I'd imagine you'd have to take it for quite a while and quite a lot to get it to last the whole day.
So it's quite a puzzling thread for me, considering I've been a big fan of this stuff for years.
There is a difference between being insane on dosage and wasting nootropics by taking so little. Three times every day i take my 1.6 g Piracetam with 100mg Picamilon and has never felt no side effects at all, to be honest i still have to figure out the Picamilon effect....i might feel i little happier but thats really subtile and ill probably drop Picamilon because its a heavy price for such a little effect.
Anyone with Picamilon will say that only direct side effect of high dosage is feeling sleepy, so when u get manic and angry on Picamilon something is wrong. It replaces my sleeping pill because its so calming.
I took 200mg Picamilon with 4g Piracetam once and there was no difference at all....Maybe youre just not responding well to it.
There's also such a thing called wasting the substance cause you're taking way more than you should. Since you say there's no difference between 200mg and 4g as opposed to 100mg and 1.6g - who's wasting their pills here?
Doesn't really increase the bioavailability much either way. Pretty sure sticking to what the instruction manual says is also pretty sound. I get no side effects from Picamilon alone at a normal dosage - but I read something like 650MG on here??? Tell me that taking THREE TIMES the dose recommended for ENCEPHALOPATHY isn't "a bit extreme" for a healthy individual, unless your body weight is something ridiculous.
Also, who says that stuff that has a "sedative effect" will necessarily make someone sleepy? It relaxes me just enough to where my natural hyperactivity goes away and my brain goes into "paradoxical stimulation" mode. Although I've done alot of benzos, so my GABA receptor sites have been in some wars before
Now it's understandable that everyone reacts differently to everything, but I'm basing this on my own experience PLUS what the actual manual says for the drug. I'm not responding well to Piracetam at all though, that's one thing I want to point out.
Also why do I keep reading that Picamilon is GABA+Niacin? I asked my grandma this, she's been a chemist for years and she says it's wrong cause it's GABA+Nicotinic acid. Can someone clarify this last point for me further? Cause I dunno where yall finding the niacin, unless I wasn't readin very attentively.