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Effects of Resveratrol on Menopause


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#1 npc3

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Posted 12 August 2009 - 01:04 AM


I started my mom on Resveratrol 500mg Transmax by Biotiva, one per day. She's been on it 9 days. She's 54, overweight by 50+ lbs and well into menopause but past the hot flash stages for about a year now. She told me today she felt her libido has come back and that her mood has improved (less cranky). I have not read much on how Res impacts menopause so would like to hear some of your experiences. It seems like all the info out there on Res and menopause is geared to sell it, or sell something. I'd like to hear some real life experiences... :p I will do my best to update on my mom's experience.
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#2 shell59

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Posted 28 August 2009 - 06:11 PM

I started my mom on Resveratrol 500mg Transmax by Biotiva, one per day. She's been on it 9 days. She's 54, overweight by 50+ lbs and well into menopause but past the hot flash stages for about a year now. She told me today she felt her libido has come back and that her mood has improved (less cranky). I have not read much on how Res impacts menopause so would like to hear some of your experiences. It seems like all the info out there on Res and menopause is geared to sell it, or sell something. I'd like to hear some real life experiences... :-D I will do my best to update on my mom's experience.

d

Hi, I think, I don't know for sure, I have asked the question but have not gotten a response that resveratrol increases Estrogen in your body. I was taking hormone replacement (Estradiol and Progesterone) and when I started the Resveratrol I started to get all my symptoms back. I stopped taking the Estradiol and I am feeling back to normal. I think with both I was getting too much Estrogen. Maybe your mom is getting Estrogen that she needs.

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#3 drmz

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Posted 28 August 2009 - 06:39 PM

Cool, this time no dogs or toes but anecdotes about woman in their menopause :-D

#4 npc3

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Posted 30 August 2009 - 09:45 PM

Yeah, I too was under the impression it did impact estrogen levels. My mom has been on it a few weeks now, she's loving it. There have been a few days where she didn't take the pill (forgot) and she really felt the impact. She reported she was tired and started getting moody again, in a negative attitude, this was after skipping a weekend of pills.

#5 shell59

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Posted 31 August 2009 - 10:52 PM

h
Cool, this time no dogs or toes but anecdotes about woman in their menopause ;)


Women in menopause or perimenopause are just as important as anyone else. Dogs and Toes are important also. It might not be something your interested in, but maybe you should be if your taking the supplement. But if your interested in heightening your own female experience I wouldn't worry because it does add Estrogen to your body.

#6 maxwatt

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Posted 01 September 2009 - 10:48 AM

h
Cool, this time no dogs or toes but anecdotes about woman in their menopause ;)


Women in menopause or perimenopause are just as important as anyone else. Dogs and Toes are important also. It might not be something your interested in, but maybe you should be if your taking the supplement. But if your interested in heightening your own female experience I wouldn't worry because it does add Estrogen to your body.


Incorrect. SEE HERE

#7 Anthony_Loera

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Posted 01 September 2009 - 12:56 PM

I believe it's progesterone...

http://content.karge...e.asp?Doi=89487

Study
"Phytoestrogen Resveratrol Suppresses Steroidogenesis by Rat Adrenocortical Cells by Inhibiting Cytochrome P450 c21-Hydroxylase"

Background and Aim: The phytoestrogen resveratrol is found in grapes, mulberries and peanuts, all of which are consumed regularly by humans. Resveratrol is also used in chemotherapy against cancer and aging and as a cardioprotectant. The aim of the present study was to characterize the effects of resveratrol on rat adrenal steroidogenesis and to study the underlying mechanism. Methods: Adrenocortical cells were isolated from the adrenal glands of normal male rats (in vitro) and from male rats administered resveratrol in their diet for 12 weeks (ex vivo). Cells from resveratrol-treated and non-treated rats were tested ex vivo for responsiveness to ACTH and cells from normal rats were tested in vitro for responsiveness to ACTH in the presence and absence of resveratrol. Corticosterone and progesterone production were measured by RIA and expression of steroidogenic enzymes analyzed by PAGE/Western blotting. Results: Corticosterone production was inhibited 47% by 50 µM resveratrol in vitro and 20% ex vivo, while progesterone production was elevated to 400% of the control value in in vitro experiments. Resveratrol treatment decreased adrenal cytochrome P450 c21-hydroxylase expression in vivo and cell culture conditions. No changes in cell viability or morphology were caused by exposure to resveratrol in both ex vivo and in vitro experiments. Conclusion: Resveratrol suppresses corticosterone production by primary rat adrenocortical cell cultures in vitro and ex vivo by inhibiting cytochrome P450 c21-hydroxylase.


Please remember, Progestorone is different than Estrogen and Testosterone. Even my wife got it confused when she wasn't really thinking about it... and me? I simply can't spell them right half the time... ;)

A

Edited by Anthony_Loera, 01 September 2009 - 01:59 PM.


#8 niner

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Posted 01 September 2009 - 04:58 PM

http://content.karge...e.asp?Doi=89487

"Phytoestrogen Resveratrol Suppresses Steroidogenesis by Rat Adrenocortical Cells by Inhibiting Cytochrome P450 c21-Hydroxylase"

Background and Aim: The phytoestrogen resveratrol is found in grapes, mulberries and peanuts, all of which are consumed regularly by humans. Resveratrol is also used in chemotherapy against cancer and aging and as a cardioprotectant. The aim of the present study was to characterize the effects of resveratrol on rat adrenal steroidogenesis and to study the underlying mechanism. Methods: Adrenocortical cells were isolated from the adrenal glands of normal male rats (in vitro) and from male rats administered resveratrol in their diet for 12 weeks (ex vivo). Cells from resveratrol-treated and non-treated rats were tested ex vivo for responsiveness to ACTH and cells from normal rats were tested in vitro for responsiveness to ACTH in the presence and absence of resveratrol. Corticosterone and progesterone production were measured by RIA and expression of steroidogenic enzymes analyzed by PAGE/Western blotting. Results: Corticosterone production was inhibited 47% by 50 µM resveratrol in vitro and 20% ex vivo, while progesterone production was elevated to 400% of the control value in in vitro experiments. Resveratrol treatment decreased adrenal cytochrome P450 c21-hydroxylase expression in vivo and cell culture conditions. No changes in cell viability or morphology were caused by exposure to resveratrol in both ex vivo and in vitro experiments. Conclusion: Resveratrol suppresses corticosterone production by primary rat adrenocortical cell cultures in vitro and ex vivo by inhibiting cytochrome P450 c21-hydroxylase.

Thanks for this ref, Anthony. It shows that a non-trivial 20% inhibition in corticosterone production was seen in rats on oral resveratrol. That was the ex vivo result, meaning that they killed the rats at the end of the resveratrol dosing period and analyzed their tissues. Further, they saw a reduced expression of the 21-hydroxylase gene expression in vivo, though they don't say by how much. That presumably was the source of the 20% inhibition in corticosterone production. Depending on the dose of resveratrol they received, this may or may not be relevant to humans, and at least warrants some attention. It's important to note that the other results given in the abstract are from in vitro experiments, meaning cells in test tubes, not organisms. (vitro means "glass", like the root of the word vitreous.) Note the concentration used: 50 micromolar. This is impossible to achieve in humans, so the other results are only of theoretical interest. They are not at all predictive of what will happen when you take a normal dose of resveratrol. The suppression and/or inhibition of 21-hydroxylase should result in a decrease in aldosterone and cortisol. The effect of resveratrol on sex hormones, outside of a test tube, isn't clear from the abstract, but might be better explained in the full text if anyone has access.

#9 malbecman

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Posted 01 September 2009 - 05:34 PM

The suppression and/or inhibition of 21-hydroxylase should result in a decrease in aldosterone and cortisol.



Less cortisol? Maybe that's why I feel less stressed......... ;)

#10 shell59

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Posted 04 September 2009 - 10:58 PM

So the issue might be that I got too much progesterone not estrogen. I was really disappointed when I got these side effects. I really wanted the benefits from using resveratrol. I also got constipated and starting having heartburn. That well may be from the progesterone. I think my husbands feet stopped hurting after he quit the Reveratrol also. I am wondering if we should try again with a much lower dose.

#11 maxwatt

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Posted 05 September 2009 - 01:58 AM

So the issue might be that I got too much progesterone not estrogen. I was really disappointed when I got these side effects. I really wanted the benefits from using resveratrol. I also got constipated and starting having heartburn. That well may be from the progesterone. I think my husbands feet stopped hurting after he quit the Reveratrol also. I am wondering if we should try again with a much lower dose.


You are the first person who has reported constipation with resveratrol use. Usually if there is any problem, the effect is quite the opposite.

In your position I would quit all supplements except D3 at 1000mg, more if you live in the Northern States or Canada. Then use a food/nutrient calculator such as CRON-O-METER to determine if my diet had any deficiencies, and correct those, and only those, by supplementation, or better yet, by improved diet. Once the basics are covered, and only then, would I consider using the phytonutrient du jour. When starting a supplement where one does not know ones tolerance, it is a good idea to start with a very low dose, and increase it over time. If no improvement is noticed, why are you taking it? Stop. And if some desirable benefit is noticed, do not increase the dosage beyond the least amount that maintains or maximizes the desired effect.

Good luck.

#12 MissM

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Posted 05 September 2009 - 02:46 AM

MaxWatt, she is not the first person to report constipation with resveratrol use. Do a search on my posts. I had severe constipation, that turned into severe diarrhea after a few months. And I do mean severe. I was tempted to try and get through it, until I saw yours or someones post about a small percentage of users that had a side effect that mimicked cholera. That was it for me.

I also have hair loss that started during the time I was taking resveratrol, and it is getting worse.

And, it is annoying when female problems are minimized, albeit in a very subtle fashion. dmrz, no doubt you were hoping for more "anecdotes'" on male virility. Get over it.


So the issue might be that I got too much progesterone not estrogen. I was really disappointed when I got these side effects. I really wanted the benefits from using resveratrol. I also got constipated and starting having heartburn. That well may be from the progesterone. I think my husbands feet stopped hurting after he quit the Reveratrol also. I am wondering if we should try again with a much lower dose.


You are the first person who has reported constipation with resveratrol use. Usually if there is any problem, the effect is quite the opposite.

In your position I would quit all supplements except D3 at 1000mg, more if you live in the Northern States or Canada. Then use a food/nutrient calculator such as CRON-O-METER to determine if my diet had any deficiencies, and correct those, and only those, by supplementation, or better yet, by improved diet. Once the basics are covered, and only then, would I consider using the phytonutrient du jour. When starting a supplement where one does not know ones tolerance, it is a good idea to start with a very low dose, and increase it over time. If no improvement is noticed, why are you taking it? Stop. And if some desirable benefit is noticed, do not increase the dosage beyond the least amount that maintains or maximizes the desired effect.

Good luck.



#13 maxwatt

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Posted 05 September 2009 - 01:01 PM

MaxWatt, she is not the first person to report constipation with resveratrol use. Do a search on my posts. I had severe constipation, that turned into severe diarrhea after a few months. And I do mean severe.

constipation followed by diarrhea, not constipation alone.

I was tempted to try and get through it, until I saw yours or someones post about a small percentage of users that had a side effect that mimicked cholera. That was it for me.

Similar to cholera in that the gut is losing water instead of absorbing it, but not caused by an organism destroying the cellular lining of the intestines, but by a chloride ion imbalance. It happens that a remedy that works for cholera (salt-sugar solution) has also been reported to work for several users here.


I also have hair loss that started during the time I was taking resveratrol, and it is getting worse.

I am sorry about your alopecia. Whether it was caused by resveratrol or is a coincidental occurrence, it must be troubling and may be a symptom of other problems. I suggest discussing it with your doctor, who might recommend a specialist in such conditions. Many cases are treatable. Dr. Proctor (doctorproctor.com) usd to have useful information on the topic, but I've not checked the site in years.


And, it is annoying when female problems are minimized, albeit in a very subtle fashion. dmrz, no doubt you were hoping for more "anecdotes'" on male virility. Get over it.

??? I think drmz was disparaging those of us who are relying too much on anecdotal evidence, not female problems in general. He is a useful skeptic.


So the issue might be that I got too much progesterone not estrogen. I was really disappointed when I got these side effects. I really wanted the benefits from using resveratrol. I also got constipated and starting having heartburn. That well may be from the progesterone. I think my husbands feet stopped hurting after he quit the Reveratrol also. I am wondering if we should try again with a much lower dose.


You are the first person who has reported constipation with resveratrol use. Usually if there is any problem, the effect is quite the opposite.

In your position I would quit all supplements except D3 at 1000mg, more if you live in the Northern States or Canada. Then use a food/nutrient calculator such as CRON-O-METER to determine if my diet had any deficiencies, and correct those, and only those, by supplementation, or better yet, by improved diet. Once the basics are covered, and only then, would I consider using the phytonutrient du jour. When starting a supplement where one does not know ones tolerance, it is a good idea to start with a very low dose, and increase it over time. If no improvement is noticed, why are you taking it? Stop. And if some desirable benefit is noticed, do not increase the dosage beyond the least amount that maintains or maximizes the desired effect.

Good luck.


Edited by maxwatt, 05 September 2009 - 01:04 PM.


#14 npc3

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Posted 19 September 2009 - 02:02 PM

Just wanted to update on my menopausal 54 year old mother who has been on 500 mg transmax resversatrol for about 1.5 months now . She has experienced migranes since starting Res, she never had them before. She's had 3. Increased estrogen is a risk factor for migranes so if Res increases estrogen I don't think it's too far fetched to assume there's a link here. However, despite the migranes which are disabling, (I'm talking migranes with nausea, light and noise sensativity, causing physical disability for a couple of hours--not just a headache) my mom refuses to stop taking the Res. She enjoys the other benefits she gets from taking it, improved mood, improved mentation, improved libido and energy, general well being. She says she'll deal with the migranes rather than stop Res.

Now I should mention that my mom is kinda scatter brained and does not consistently take the Res every day on an empty stomach at the same time. She'll skip doses for days at a time and then restart.

Next bottle I give her will be 250 mg, will report back in a couple of months.

#15 madanthony

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Posted 02 April 2010 - 07:21 PM

I believe it's progesterone...

http://content.karge...e.asp?Doi=89487

Study
"Phytoestrogen Resveratrol Suppresses Steroidogenesis by Rat Adrenocortical Cells by Inhibiting Cytochrome P450 c21-Hydroxylase"

Background and Aim: The phytoestrogen resveratrol is found in grapes, mulberries and peanuts, all of which are consumed regularly by humans. Resveratrol is also used in chemotherapy against cancer and aging and as a cardioprotectant. The aim of the present study was to characterize the effects of resveratrol on rat adrenal steroidogenesis and to study the underlying mechanism. Methods: Adrenocortical cells were isolated from the adrenal glands of normal male rats (in vitro) and from male rats administered resveratrol in their diet for 12 weeks (ex vivo). Cells from resveratrol-treated and non-treated rats were tested ex vivo for responsiveness to ACTH and cells from normal rats were tested in vitro for responsiveness to ACTH in the presence and absence of resveratrol. Corticosterone and progesterone production were measured by RIA and expression of steroidogenic enzymes analyzed by PAGE/Western blotting. Results: Corticosterone production was inhibited 47% by 50 µM resveratrol in vitro and 20% ex vivo, while progesterone production was elevated to 400% of the control value in in vitro experiments. Resveratrol treatment decreased adrenal cytochrome P450 c21-hydroxylase expression in vivo and cell culture conditions. No changes in cell viability or morphology were caused by exposure to resveratrol in both ex vivo and in vitro experiments. Conclusion: Resveratrol suppresses corticosterone production by primary rat adrenocortical cell cultures in vitro and ex vivo by inhibiting cytochrome P450 c21-hydroxylase.


Please remember, Progestorone is different than Estrogen and Testosterone. Even my wife got it confused when she wasn't really thinking about it... and me? I simply can't spell them right half the time... :|?

A

Anyone know how much reservatrol in a glass of grape juice? I don't take reservatrol but I drink a glass of grape juice every day and hope I'm doing good? I am addicted to grapes and grape juice. I have never been able to take progesterone or vitex, which stimulates it, w/o CRYING. I have never determined if the problem is a short half-life and symptoms actually caused by its decline (maybe I needed to take it 2x/day. I have no problem with a glass of grape juice, but maybe it's not enough to add up to anything?

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#16 madanthony

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Posted 02 April 2010 - 08:27 PM

So the issue might be that I got too much progesterone not estrogen. I was really disappointed when I got these side effects. I really wanted the benefits from using resveratrol. I also got constipated and starting having heartburn. That well may be from the progesterone. I think my husbands feet stopped hurting after he quit the Reveratrol also. I am wondering if we should try again with a much lower dose.


You are the first person who has reported constipation with resveratrol use. Usually if there is any problem, the effect is quite the opposite.

In your position I would quit all supplements except D3 at 1000mg, more if you live in the Northern States or Canada. Then use a food/nutrient calculator such as CRON-O-METER to determine if my diet had any deficiencies, and correct those, and only those, by supplementation, or better yet, by improved diet. Once the basics are covered, and only then, would I consider using the phytonutrient du jour. When starting a supplement where one does not know ones tolerance, it is a good idea to start with a very low dose, and increase it over time. If no improvement is noticed, why are you taking it? Stop. And if some desirable benefit is noticed, do not increase the dosage beyond the least amount that maintains or maximizes the desired effect.

Good luck.

I very strongly disagree with this view. Someone else brought up the loss of nutrients that occurs as food is aged and shipped. that is only one aspect, there are many others:
(1) Tools like this use the minimum daily allowance, which is a measure of the MINIMUM requirement of a nutrient to prevent outright disease (NOT a measure of how much is required for health, nor for OPTIMAL health)
(2) The minimum daily allowance is based on short term tests and not generally reflective of the amount of a nutrient required to prevent LONG-TERM disease. (For instance, the iodine requirement was set based on the minimum to prevent goiter w/o knowledge or regard for the fact that breast tissue has iodine receptors and the Japanese, who consume an order of magnitude (12.5 mg/day) more iodine than Americans, have an extremely low rate of breat cancer unlike Americans).
(3) The minimum daily requirement is based on "the average person" and there is no such thing as an average person.
(a) As recent research has been showing, there are many genotypes out there which affect enzyme binding of cofactors, making higher vitamin cofactors required for those individuals. Some common genotypes, such as MTHFR C677T are actually increasing globally. Sports nutrition, which is a study of OPTIMAL nutrition, shows according to Dr. michael Colgan, for instance, remarkably huge differing individual requirements for niacin.
(b) People make different lifestyle choices which affect their nutritional requirements way beyond any MDR. For instance, the MDR for calcium is measured in the "average person" but vegetarians who do not eat meat do not have as high of a calcium requirement (meat is acidic and makes one lose calcium in order to correct ph).
© People's past dietary choices affect their present requirements (nothing to do with MDR). For example, if you eat a diet that does not have FOS and other such things to feed the helpful gut flora, not so helpful flora will colonoze, and will consume some of the nutrients you eat as well as give off acid wastes requiring alkaline minerals to de-acidify.
(d) Another way that past dietary choices affect current nutritional requirements is that deficiencies cause the buildup of potentially harmful partial metabolites - for instance, a deficiency in any methyl cycle nutrient (methionine, P5P, l-methylfolate, methylcobalamine, B2, betaine/choline, ATP), will cause the buildup of homocysteine, which requires more nutrients to clear it.
(e) Another way that past dietary choices affect current nutritional requirements is that deficiencies may cause enzyme deficiencies or ATP deficiency that may be very hard or impossible to replace. Active vitamins can be taken (which are not listed in CRON-o-Meter) such as P5P instead of B6 (where B6 will do NO GOOD if you haven't the enzymes necessary to turn it into P5P), and the people with ATP issues (chronic fatigue) find it very hard to escape this catch 22. It can be done, but most people never manage to figure out how.
(4) A whole lost of necessary nutrients are not listed in CRON nor are a whole lot of foods. And it makes a world of difference, how a food is prepared. If the exact food prepared the exact way is not listed, choosing something "close" is meaningless.

SO. Tools like CRON-o-Meter are of passing minimal interest to suggest possible gross dietary deficiencies but if you have a symptom, you should not trust CRON but should start looking for a solution.

I basically would not trust CRON at all because I observe most Americans have mood problems at least by the time they are my age and I observe the quality of types of foods most Americans eat and I deduce easily lack of vitamin content. In whole grocery stores I cannot find a single loaf of stone ground whole wheat bread with all the natural B vitamins in it, and I shudder for the average American who does not supplement with B complex. So...if it detects a deficiency you probably have a SEVERE deficiency. If it does not, don't for a minute believe you are home free.




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