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Posinol™ for mood disorders/depression

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#1 NeverSayDie

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Posted 14 November 2009 - 01:28 AM

Posinol is made with an extract from the leaves of Apocynum venetum L., a wild plant grown in Asia. Posinol™ contains no less than 4% of the flavonoid glycosides-isoquercitrin and hyperoside. Hyperoside is known to be most efficacious in mental relaxation and reducing blood pressure. It works with the brain's naturally-occurring chemicals called neurotransmitters, including norepinephrine and dopamine. Posinol™ differs from St. John's wort in that it does not contain hyperforin, an active compound that interacts with the metabolism of certain pharmaceuticals.

"An Asian botanical used for emotional well-being is Apocynum venetum L. In vitro trials suggest Apocynum venetum have significant antioxidant effects, which may inhibit lipid peroxidation in the central nervous system.20 Animal trials investigating the impact of the botanical extract have found it exerts antixolytic activity mediated by the GABAergic system,21 and also reduces norepinephrine and dopamine concentrations, similar to the action of imipramine.22 Further, studies have shown Apocynum venetum extract does not impact the CYP3A pathway the way St. John's wort does, eliminating the possibility of drug interactions.23 OptiPure offers a patented form of Apocynum venetum called Posinol™, which contains no less than 4 percent of the flavonoid glycosides isoquercitrin and hyperoside, which support mental relaxation. Case study reports, provided by the ingredient producer Tokiwa Phytochemical Co., show 50 mg/d of Posinol can help reduce symptoms of mild to moderate depression. Company studies also show Posinol shortens the immobility time in an animal model for antidepressant activity." - http://www.naturalpr...l-wellness.aspx

This is also supplied by Ecological Formulas.


#2 NeverSayDie

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Posted 14 November 2009 - 01:30 AM

J Ethnopharmacol. 2007 Apr 4;110(3):406-11. Epub 2006 Oct 13.

<h1 class="title">Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.</h1>Grundmann O, Nakajima J, Seo S, Butterweck V.

College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesvilla, FL 32610, USA.

The purpose of this study was to characterize the putative anxiolytic-like activity of an ethanolic extract prepared from the leaves of Apocynum venetum (AV) using the elevated plus maze (EPM) in mice. Male C75BL/6 mice were either treated orally with the AV extract or the positive controls diazepam and buspirone, respectively, 1h before behavioral evaluation in the EPM. A single treatment of AV extract markedly increased the percentage time spent on and the number of entries into the open arms of the EPM in doses of 30 and 125 mg/kg p.o., respectively. This effect was comparable to that of the benzodiazepine diazepam (1.5 mg/kg p.o.) and the 5-HT(1A) agonist buspirone (10 mg/kg p.o.). The effects of AV in 125 mg/kg were effectively antagonized by the benzodiazepine antagonist flumazenil (3 mg/kg i.p.). However, the effects of AV extract could only partially be blocked by the unspecific 5-HT(1A) receptor antagonist WAY-100635 (0.5 mg/kg i.p.). Neither diazepam and buspirone nor the AV extract produced any overt behavioral change or motor dysfunction in the open field test. These results indicate that AV extract is an effective anxiolytic agent, and suggest that the anxiolytic-like activities of this plant are mainly mediated via the GABAergic system.

PMID: 17101250 [PubMed - indexed for MEDLINE]


Edited by NeverSayDie, 14 November 2009 - 01:32 AM.

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#3 spermidine

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Posted 28 February 2013 - 06:37 PM

never heard of this plant before. anyone ever used it ? any updates ? it seems quite old thread.

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#4 MarcD

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Posted 01 March 2013 - 09:34 PM

it's a common used herb in tcm named Luo Bu Ma. It calms the liver (calms irritability, anxiety, ... ), it clears heat and promotes urination.

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