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Magnesium Supplement Helps Boost Brainpower


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#1 babcock

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Posted 02 February 2010 - 01:32 PM


http://www.scienceda...00127121524.htm

Because it is difficult to boost brain magnesium levels with traditional oral supplements, Dr. Liu and colleagues developed a new magnesium compound, magnesium-L-threonate (MgT) that could significantly increase magnesium in the brain via dietary supplementation. They used MgT to increase magnesium in rats of different ages and then looked for behavioral and cellular changes associated with memory.


A close examination of cellular changes associated with memory revealed an increase in the number of functional synapses, activation of key signaling molecules and an enhancement of short- and long-term synaptic processes that are crucial for learning and memory.

The authors note that the control rats in this study had a normal diet which is widely accepted to contain a sufficient amount of magnesium, and that the observed effects were due to elevation of magnesium to levels higher than provided by a normal diet.


Hopefully someone will release a MgT supplement in the near future.

Link to another imminst post for another article about the same study:

http://www.imminst.o...mp;#entry379425

#2 widit

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Posted 25 February 2010 - 12:37 PM

WOW! really cool paper!!!!! read it and showed it some colleagues. nice find!

the paper they were talking about is in JCB
http://www.ncbi.nlm....mp;ordinalpos=1

Edited by widit, 25 February 2010 - 12:39 PM.


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#3 chrono

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Posted 22 March 2010 - 11:08 AM

Here are the abstracts so far:

Enhancement of learning and memory by elevating brain magnesium.
Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G.

Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions.


Kalzium ist nicht alles.
Bush AI.

Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular Mg2+ elevation mimics sustained synaptic Zn2+ concentrations by increasing hippocampal NR2B expression and bouton density.



#4 outsider

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Posted 23 March 2010 - 08:26 AM

5 years ago I came upon specialists on internet that claimed that magnesium had a deep impact on brain plasticity. They said magnesium was the gate keeper of nmda if I remember correctly. Wait I'm going to look in my files... there it is:

http://www.medicalne...hp?newsid=17114

"Magnesium is the gatekeeper for the NMDA receptor, which receives signals from an important excitatory neurotransmitter involved in synaptic plasticity. Magnesium helps the receptor open up for meaningful input and shut down to background noise. "As predicted by our theory, increasing the concentration of magnesium and reducing the background level of noise led to the largest increases of plasticity ever reported in scientific literature," Liu said."

http://www.vrp.com/art/1613.asp

"According to the cover story of the December 2 issue of Neuron, magnesium may also perform a lesser-known role: supporting cognitive function."


http://www.falconbla...s/magnesium.htm

"Alzheimer's Disease is, in many ways, accelerated aging of specific parts of the brain. "Oxidative stress and neurodegenerative processes are accompanied by a pronounced magnesium dificiency."

The Miracle of Magnesium

By Carolyn Dean, MD, ND
Magnesium deficiency triggers or causes the following 22 conditions; the introduction of magnesium, either by a high-magnesium diet, with green drinks, or magnesium supplements, can help alleviate these conditions:
1. Anxiety and panic attacks
2. Asthma
3. Blood clots
4. Bowel disease
5. Cystitis
6. Depression
7. Detoxification
8. Diabetes, Syndrome X,
and Metabolic Syndrome
9. Fatigue
10. Heart disease
11. Hypertension
12. Hypoglycemia 13. Insomnia
14. Kidney Disease
15. Liver Disease
16. Migraine
17. Musculoskeletal conditions
18. Nerve problems
19. Obstetrics and Gynecology--premenstrual syndrome, dysmenorrhea (cramping pain during menses), infertility, premature contractions, preeclampsia, and eclampsia in pregnancy, lessens the risk of cerebral palsy and Sudden Infant Death Syndrome (SIDS)
20. Osteoporosis
21. Raynaud's Syndrome
22. Tooth decay

Science and medicine have both turned their backs on magnesium. Science opts out because the scientific methodology is defined by being able to test one thing at a time ending up with one result. Science finds magnesium too difficult to corral, partly because it is responsible for the correct metabolic function of over 350 enzymes in the body. The creation of ATP (adenosine triphospate) the energy molecules of the body, the action of the heart muscle, the proper formation of bones and teeth, relaxation of blood vessels, and the promotion of proper bowel function are all under the guidance of magnesium.

...

Why Don't We Hear More About Magnesium?
Medicine has turned its back on magnesium because most of the funding for medical research now comes from drug companies. Magnesium is not a patented drug and therefore will not be studied by drug companies, except to try to disprove its action.

...

Up to 80 Percent of Americans are Magnesium-Deficient
-------
Back then I figured the best way to get magnesium was the ionized form.

#5 Athletix

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Posted 25 March 2010 - 01:25 PM

I actually have found a source for this if anyone is interested. Only problem is it is tough to try and convert murine dosages to human dosages. You could take a normal dose of Mg, but it is difficult to tell whether or not it would still have positive cognitive benefits. With the spike in acetylcholine levels shown, in the journal Neuron, created by MgT one would think you wouldn't need much. Athletes have used Mg at dosages of 250mg at night and experienced increased sleep quality and vivid dreams, which one could assume says that some is making across the BBB. 100-150mg of MgT might be where I would start.

Has anyone used this yet?

#6 adamh

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Posted 25 March 2010 - 07:51 PM

I'm taking 4 - 225mg doses per day and getting nice effects. Stools are a bit loose but not so much as to be a problem. Actually, that part is not so bad either. Better than the opposite if you know what I mean.

#7 xzibit

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Posted 25 March 2010 - 08:25 PM

Would a person have to be deficient in mg in order to benefit from taking it? Is it just MGt that increases acetylcholine levels?

#8 nito

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Posted 25 March 2010 - 08:51 PM

I'm taking 4 - 225mg doses per day and getting nice effects. Stools are a bit loose but not so much as to be a problem. Actually, that part is not so bad either. Better than the opposite if you know what I mean.



U take citrate?

#9 outsider

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Posted 26 March 2010 - 08:40 AM

If I would take magnesium it would be ionic magnesium like this:

http://www.evolution...s/Magnesium.htm

Ionic magnesium seems to be 100% bioavailable. But I'm sure there are other good ionic magnesium products, I just did a rapid search.

I found this part interesting in one site:

Low Level Magnesium and Heavy Metal Poisoning
Heavy Metal poisoning: Magnesium protects the cell from aluminum, mercury, lead, cadmium, beryllium and nickel. Evidence is mounting that low levels of magnesium contribute to the heavy metal deposition in the brain that precedes Parkinson's, multiple sclerosis and Alzheimer's. It is probable that low total body magnesium contributes to heavy metal toxicity in children and is a participant in the etiology of learning disorders.

Also this:

The activation of B vitamins, adrenals, brain and nervous system.

#10 mclaren779

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Posted 30 March 2010 - 02:23 AM

I actually have found a source for this if anyone is interested. Only problem is it is tough to try and convert murine dosages to human dosages. You could take a normal dose of Mg, but it is difficult to tell whether or not it would still have positive cognitive benefits. With the spike in acetylcholine levels shown, in the journal Neuron, created by MgT one would think you wouldn't need much. Athletes have used Mg at dosages of 250mg at night and experienced increased sleep quality and vivid dreams, which one could assume says that some is making across the BBB. 100-150mg of MgT might be where I would start.

Has anyone used this yet?


I would be interested in the source I googled it and no responses I guess it's still to new.

#11 chrono

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Posted 31 March 2010 - 08:20 PM

I actually have found a source for this if anyone is interested. Only problem is it is tough to try and convert murine dosages to human dosages.


I'm sure everyone would be interested in finding a source, yes. Assuming it is of reasonable purity.

The dosage estimation will be a little iffy. Anyone know of any dosage info for other threonate substances?

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#12 matter_of_time

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Posted 01 April 2010 - 09:26 AM

THANK YOU ALL

just (3 days) started with taking a magnesium complex

it makes a huge difference on my stress levels.




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