"Hangover" was probably too strong a word. Just some slightly lingering adverse effects the next morning. I've only noticed this twice, and it was when I used a patch slice twice within 3 days. It's not that much of a bother, but I'm on the lookout for anything that may indicate unhealthy vasoconstriction. I expect it's affecting me more than most, as I'm very out of shape due to a very protracted back injury.
I might try gum, though it's a more unhealthy ROA. It also seems like it would deliver nicotine in a burst compared to the slow transdermal release.
Honestly, the unpleasantness of the effects themselves are more than offset by the effect nicotine has on my dreams. Long, cinematic and vivid all night. I feel much more engaged, perhaps like my executive functions are more intact, rather than "watching myself." I had a very short spontaneous lucid dream a week or two back for the first time in my life, on a night after nicotine. Piracetam dreams as well when I haven't had it in a while, but nicotine is much more intense over the course of the whole night. If I actually forget to take the patch off, it's sometimes almost too intense. I enjoy even my bad dreams, but it's something to consider if you don't.
A meta-analysis of the cognitive effects of nicotine was published yesterday: http://www.ncbi.nlm....pubmed/20414766
Interesting results! Honestly, I don't notice much cognitive or focus enhancement from nicotine. I take it most for the dopamine release, slight though it is compared to amphetamine salts. I get greatly enhanced focus right now from a combination of piracetam/ALCAR, but the dopaminergic component is missing when it comes to task avoidance and initiating social contact. On the Attention Network Task spectrum, this sounds more like the Executive attention component to me, which they didn't include in the meta-analysis.
An interesting abstract relevant to my benefits:
Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD).
Nicotine, like the psychostimulants methylphenidate and dextroamphetamine, acts as an indirect dopamine agonist and improves attention and arousal. Adults and adolescents with attention deficit hyperactivity disorder (ADHD) smoke much more frequently than normal individuals or those with other psychiatric conditions, perhaps as a form of self-medication for ADHD symptoms. Nicotine might therefore have some value as a treatment for ADHD. The present study is an acute double-blind crossover administration of nicotine and placebo with smokers (n = 6) and nonsmokers (n = 11) diagnosed with adult ADHD. The drug was delivered via a transdermal patch at a dosage of 7 mg/day for nonsmokers and 21 mg/day for smokers. Results indicate significant clinician-rated global improvement, self-rated vigor and concentration, and improved performance on chronometric measures of attention and timing accuracy. Side effects were minimal. These acute results indicate the need for a longer clinical trial and a comparison with other stimulants in adult ADHD treatment.
PMID: 8927677 [PubMed - indexed for MEDLINE]
dfowler, it seems quite possible that it's both good and bad in the long run, through different mechanisms. My feeling is that any putative long-term benefits can be derived from other substances with fewer risks/AEs.
Edited by chrono, 29 September 2010 - 12:53 PM.