I came across a patent for water-soluble curcumin which involve raising pH to obtain a water soluble basic form, then adding gelatin, and lowering pH leaving the curcumin bound to the gelatin in solution.
I wondered if it were possible to make an equivalent drink to SRT501 using gelatin instead of HPMC/DOSS or Tween80.
I've done some kitchen chemistry to see what would work with resveratrol. First, i did not try to change the pH, to avoid conversion to cis-resveratrol. Add half a teaspoon (5 ml) of unflavored gelatin to 4 ounces (125 cc) of water. Heating to 100 degrees and stirring vigorously is necessary for it to dissolve quickly. Then add 500 mg of 98% resveratrol power and stir vigorously for 30 seconds. When I did this, the solution turned milky white. Inspection revealed some small particles which remained suspended, only the largest (under 5%) settling. After half an hour the solution was still cloudy, most of the suspended particles too small to see as such even with a hand-lens. Some visible particles remained suspended due to Van der Waals forces. Note, the resveratrol I used was not micronized; I believe using micronized resveratrol would result in no settling of resveratrol particles.
I suppose one could use flavored gelatin. Unflavored gelatin makes for a bland-tasting drink. Heated to 300 degrees and baked in muffins, resulted in the loss through decomposition of about 30% of the resveratrol in one published study. The stability at 100 degress or less should be no problem, or you could let the solution cool to room temperature before adding resveratrol.
I've been using my fasting blood glucose as a proxy measurement to attempt to evaluate the effectiveness of different delivery systems for resveratrol. Very preliminary, I've only one measurement so far, but this method resulted in lower fasting glucose for me than just swallowing resveratrol powder or attempting bucal delivery. It could be a coincidence, or confounding factors, so I will keep measuring.
I hope Browser finds this a suitable delivery system for his problem. I expect Anthony will go to the supermarket to buy some gelatin this morning. Maybe we can come up with a recipe for resveratrol Jello Shots.
Mixing the solution and storing it refrigerated should prove stable for at least a month. Trela investigated the stability of resveratrol in aqueous solution and found it stable for that long, as long as the pH was below 11 and it was not exposed to UV light. I expect a few days storage will not be a problem.