I stumbled across this on pubmed looking for something else. It contains Rehmannia root, Poria whole plant, Chinese yam root, Asiatic dogwood aerial part, Barrenwort aerial part, Water plantain aerial part, Astragalus root and Cassia bark. Anybody familiar with this and/or have any experiences to report?
Effect of hachimijiogan, an oriental herbal medicinal mixture, on experimental amnesia in mice.
Hirokawa S, Nose M, Ishige A, Amagaya S, Ogihara Y.
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
The effect of Hachimijiogan on cognitive disturbance was investigated using step-through passive avoidance failure techniques: scopolamine-, cycloheximide- and cerebral ischemia-induced amnesia. Pre-acquisition trial administration of Hachimijiogan (0.5 g/kg, p.o.) prolonged the step-through latency reduced by scopolamine and cycloheximide. Hachimijiogan (0.5 and 1.0 g/kg, p.o.) also ameliorated the cerebral ischemia-induced amnesia. Physostigmine (0.1 mg/kg, i.p.) ameliorated all three amnesia models. The ameliorating effects of Hachimijiogan and physostigmine on cycloheximide-induced amnesia were diminished by the combination with scopolamine. These results suggest that Hachimijiogan possesses a wide-ranging pharmacological profile in anti-amnesic actions and that its anti-amnesic activities may be related to the cholinergic neuronal system.