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Hachimijiogan herbal complex

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#1 Guacamolium

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Posted 28 May 2010 - 02:38 PM

I stumbled across this on pubmed looking for something else. It contains Rehmannia root, Poria whole plant, Chinese yam root, Asiatic dogwood aerial part, Barrenwort aerial part, Water plantain aerial part, Astragalus root and Cassia bark. Anybody familiar with this and/or have any experiences to report?

Effect of hachimijiogan, an oriental herbal medicinal mixture, on experimental amnesia in mice.

Hirokawa S, Nose M, Ishige A, Amagaya S, Ogihara Y.

Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.

The effect of Hachimijiogan on cognitive disturbance was investigated using step-through passive avoidance failure techniques: scopolamine-, cycloheximide- and cerebral ischemia-induced amnesia. Pre-acquisition trial administration of Hachimijiogan (0.5 g/kg, p.o.) prolonged the step-through latency reduced by scopolamine and cycloheximide. Hachimijiogan (0.5 and 1.0 g/kg, p.o.) also ameliorated the cerebral ischemia-induced amnesia. Physostigmine (0.1 mg/kg, i.p.) ameliorated all three amnesia models. The ameliorating effects of Hachimijiogan and physostigmine on cycloheximide-induced amnesia were diminished by the combination with scopolamine. These results suggest that Hachimijiogan possesses a wide-ranging pharmacological profile in anti-amnesic actions and that its anti-amnesic activities may be related to the cholinergic neuronal system.

#2 chrono

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Posted 31 May 2010 - 08:53 PM

Good find! It seems to have many physiological benefits as well. Though personally, I'm more comfortable taking things which have better-defined mechanisms, rather than a soup of plants whose components and combinations have uncertain effects. This is an interesting contrast to many here, who are much more comfortable taking "natural" or "traditional" medicines.

Here's another cognitive-related study, using its Chinese name:

A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia.
Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Cho S, Akiba T, Arai H, Cyong JC, Sasaki H.

OBJECTIVES: To evaluate whether a traditional Chinese herbal medicine, ba wei di huang wan (BDW), improves cognitive and physical functioning in dementia patients. DESIGN: An 8-week randomized, double-blind, placebo-controlled trial. SETTING: Long-term-care facility in Japan. PARTICIPANTS: Thirty-three patients with mild to severe dementia (7 men and 26 women; mean age +/- standard deviation=84.4 +/- 7.8) were recruited and enrolled from May 2002 through September 2002. INTERVENTION: Participants were randomly assigned to the active drug (BDW) group (n=16) or the placebo group (n=17) and treated for 8 weeks. MEASUREMENT: Cognitive function and activities of daily living (ADLs); palsatility index. RESULTS: After the trial, cognitive function as assessed using the Mini-Mental State Examination (MMSE) significantly improved from 13.5 +/- 8.5 to 16.3 +/- 7.7 (P<.01, 95% confidence interval (CI)=-4.1 to -1.4) in the BDW group. The ADL score in the Barthel Index also significantly changed, from 61.8 +/- 34.6 to 78.9 +/- 21.1 (P<.01, 95% CI=-26.2 to -7.9). In contrast, MMSE and Barthel Index scores of the placebo group showed no significant change. Eight weeks after the end of the administration, MMSE and Barthel Index scores of the BDW group declined to the baseline level. The pulsatility index in the internal carotid artery as measured using Doppler sonography significantly decreased in the BDW group (2.5 +/- 1.7 to 1.9 +/- 0.5, P<.05) but not in the placebo group. CONCLUSION: These results argue the benefits of BDW in the treatment of dementia. Copyright 2004 American Geriatrics Society

PMID: 15341554 [PubMed - indexed for MEDLINE]

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#3 Lufega

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Posted 30 November 2011 - 09:26 PM

It seems to also be a potent prolactin inhibitor and it works by increasing dopamine. It works so well that it's able to treat bromocriptine resistant hyperprolactinemia with apparently no side effects.

http://www.ncbi.nlm....iogan prolactin
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