10 replies to this topic

[lourdaud]

Hi everyone!

First of all, thanks for a great forum! Really glad I found it, it's just what I've been looking for. Perhaps not exactly what I need though, as it's been a major source of distraction ever since, and I've got a lot of stuff that need's to be done, hehe.

I figured that I could probably spend a year or so just reading about supplements and smart-drugs before I'll be able to really decide what to buy and what to cancel-out, so I thought I'd make a smaller investment for now and add more ingredients eventually.

Short about me:
I'm a male in his twenties, suffer from "Asperger", or autism if you prefer, although mild (yeah that's what everyone says but really.. haha), ADHD and Tourette. Also rather depressed and big problems with anxiety.
I exercise a lot (cardio and weight training) and I'm in very good health. Since a couple of years back I've been eating a low-carb diet, and lately I've switched to a true ketonic diet and find that I feel really well on it.

I daily take 25 mg of Dexedrine for the ADHD problems, and 15 mg of escitalopram (Lexapro) + 22,5 mg of mirtazapine to cope with depression.
I also take the following supplements on a daily basis:

Green tea 3 - 4 times a day
ALCAR: 500 mg x 3
Gingko Biloba: 100 mg x 2
L-Theanine: 200 mg
Omega-3: 3 g x 2
Vitamin D 2500 IU (don't know if I got that unit right..)
Multi-vitamin complex x 1
Selenium complex 200 mcg
Vitamin E 20 mcg
Zink & Magnesium-combo before bed

(occasionally I'll also take some L-Tyrosine and DMAE)


Although I'm definitely interested in improving over-all health, I'm now first and foremost looking for supplements to improve mood and cognitive functions. I've therefore been looking into the following ones:

Memantine
Vitamin B-complex
methylcobalamin and folinic acid (after reading niner's post in this thread: http://www.longecity...spergers-stack/)
NAC (from caruga's experiences noted in the same thread. No idea if neither of this will help me but it's worth a try!)
Lithium orate (low dose)
Manganese
Holy Basil
Bacopa
Lion's Mane

I've read a lot of warnings on taking racetams together with amphetamines so I'm not sure I would want to start taking one every day.. I think however that I'll buy me some Aniracetam just to try, could be something that might come in handy on exams etc.
If someone question the claimed dangers of amphetamines+racetams, please tell me so! I'd be more than happy to indulge in them

I'd highly appreciate any kind of advice, either on my current stack or if you got any other suggestions!


Cheers!

[Willou]

For the GAD, I advise that you do not take ALCAR and/or Tyrosine within the time frame Adderall remains in your your bloodstream, at least not the minimum of eight hours. Those could cause over-stimulation. I had some anxiety when I used Tyrosine concurrently with Adderall. Lion's Mane seems to have more long term benefits than something immediately noticed. I use PQQ along with Adderall, which seems to give me more natural energy. PQQ is also protective from Adderall's damage caused by potential excitotoxicity and/or oxidative stress.

I also would not use Adderall concurrently with Piracetam. Each time that I've used them together, I felt great for the first day or two, then I was left mentally and physically fatigued, in a state of apathy. I believe that'd be caused by the over-activation of the NMDAr.

If you do go ahead with the B-vitamin complex, I would advise against B-100 complex, as some of the amounts are the maximum recommended for the particular vitamin.

If your multivitamin contains a high amount of Vitamin C, do not take it within two hours of administering Adderall.

[lourdaud]

Willou:
Thanks for your advice!
Regarding taking ALCAR with amphetamine I don't have any problems with it, but then I do take dexamphetamine.
I've been taking 7,5 g Piracetam and 1,5 g Aniracetam with 17,5 - 20 mg dexamphetamine daily for the last two weeks, and so far, so good! really hope it will last and that I'm not doing anything stupid...

I will be looking in to PQQ, looks interesting, thanks!

[lourdaud]

Anyway, I've been reading up a lot on supplements and nootropics since my last post and right now I have the following stack:
If you have any advice or suggestions whatsoever, I'd be very happy if you'd let me know, as I really don't know what I'm doing. I've just added a bunch of stuff that seems great but I have no idea if there are any dangers in combining all this

5:30, upon awakening:

8 mg dexamphetamine
10 mg escitalopram
2,5 g Piracetam
0,5 g ALCAR
5 g Lecithin (NOW Foods Non-GMO)
3 g Omega-3 (NOW)
1 capsule Thorne Basic B Complex
1 mg Methyl B-12 (Jarrow Lozenge)
300 mg Silymarin
20 mg Vitamin E
200 mcg Selenium
30 mg CoQ10
500 mg Glucosamine
200 mg Gingko Biloba
200 mg l-theanine

5:45 - 6:30: brisk walk or resistance training

7:00, breakfast: two cups of green tea

8:30 - 9:00, before school:
4 mg dexamphetamine
more green tea
5 mg lithium (from lithium orotate)
2,5 g Piracetam
1000 mg TMG
50 mg Picamilon
Ashwaganda 450 mg
Holy Basil extract 500 mg
200 mg l-theanine

12:00 - 12:30, before lunch:
3,5 mg dexamphetamine
more green tea
5 mg Lithium
2,5 g Piracetam
0,5 g ALCAR
600 mg NAC
500 mg Glucosamine
200 mg Ginkgo Biloba
3 g Omega-3
200 mg l-theanine

15:00:
2,5 mg dexamphetamine
more green tea
2,5 g Piracetam
1000 mg TMG
500 mg Holy Basil extract
200 mg l-theanine
Solgar Super B Complex with Vitamin C

17:00:
2,5 g Piracetam
0,5 g ALCAR
150 mg ALA
5 g Lecithin
150 mg ALA or 600 mg NAC
400 mg l-theanine
3 g Omega-3

19:00 - 20:00:
one or two glasses of red wine
5 mg lithium
450 mg Ashwaganda
250 mg Bacopa leaf extract 20:1
0,5 g Lion's Mane (liquid form, 15 drops)
500 mg ZMA


21:00, before bed:
37,5 mg Mirtazapine
500 mg GABA
1000 mg TMG

This is just the typical daily intake which can differ quite a lot though.
As I mentioned I'm also on a keto-diet, and today I started to use the cron-o-meter and vitamin and mineral intake seems to be just fine except for the ones that I supplement, so no worries there I think..
Most days I throw in a bit of Aniracetam or Oxiracetam aswell, and every once in a while I take the following ones:
Daily vitamins (weak formula)
4 - 8 mg Manganese
150 - 300 mg DMAE (just sometimes instead of the ALCAR)
l-tyrosine or phenylaline or Sulbutiamine (just when really needed and in very small doses)
Phenibut (not more than once a week, small dose aswell)

On its way (there was a sale on LEF products on iHerb ) :
LEF two-per-day
LEF Quercetin
LEF Super K
LEF l-taurine
LEF Forskolin
LEF Super Selenium


Will buy:

Magnesium l-threonate
Noopept
Afobazole
NPEP12
pyritinol
Reishi
Gotu Kola
Cordyceps
GSE

Reservatol or Wine Rx (just ran out on Transreservatol but I will read up more upon it as there seems to be a lot of questions regarding efficacity and dosage etc..)
Curcumin (right now I'm using it as a spice, along with a lot of garlic as much as I can instead. just hope my sweat doesn't smell too bad )

Also, creatine, maybe.. but concerned about all the water you put on..

Curious of, but hesitant as they're all expensive:

Selank
Memantine
Naltrexone (I have a nasty habit of opiate bingeing every once a week which really isn't optimal)
Cerebrolysin
Oxytocin and Way-267464
Semax

[Willou]

How old are you exactly? Based on what I've read, resveratrol can have a negative affect on one's sexual maturation; so the advice was that he should not take it until he's 25. With the Lion's Mane, make sure the extract is from the mycelium. http://www.longecity...timulating-ngf/


This is the best I've found: http://www.iherb.com...Caps/21455?at=0

[thedevinroy]

I got your message to give critique on this stack. I took a few glances at it and realized that I have to spend some serious thought into this, so I came back to it. What you have done is essentially taken everything. Yes, nootropics are cool, but rarely should they be used in mass quantities and varieties by one individual. It's a bit overboard. For more specific things....

• TMG may keep you up an night or help you wake up, depending on the type of person you are.
• Forskolin may counteract the focus-effects of Dexedrine. It is the flagship of raising cAMP levels. cAMP is no so good for the ADHD pre-frontal cortex.
• GABA by itself cannot cross the blood-brain barrier. Consider instead herbs that increase GABA: lemon balm, gotu kola, and valerian root. Or picamilon which you already take.
• Silymarin itself is not that bioavailable due to the harsh environments in you stomach. Consider taking in a timed release form.

I find it strange that you mix stimulants with sedatives... I've done it before when I was taking a lot of over-the-counter stimulants, but ultimately I found it extremely hard to regulate the proper combination to achieve a consistent energy level. The stimulants would wear you down time after time of repeated administration and you wouldn't know if you took too much or too little until they wore off. When they wore off, some sedating effects were still around and the crash was even more intense. Please look at the effects of each supplement and consider their effectiveness, duration, and optimal time to take it a little bit further.

Stimulants: Dexedrine (NDRI), Green Tea (adenosine blocker, COMT inhibitor), TMG (methyl donors), B Vitamins (cofactors), Piracetam and Oxiracetam (cholinergic, glutamatergic), ALCAR (cholinergic, glutamatergic, metabolic enhancer), tyrosine (precursor), Quercetin (MAOi, COMT inhibitor), Forskolin (PDE inhibitor), Gingko Biloba (NET inhibitor), Pyritinol (cofactor), DMAE (cholinergic, methyl doner), phenylalanine (precursor), Sulbutiamine (DRI, also indirectly releases DA as thiamine polyphosphates), ALA (metabolic enhancer), Lecithin (cholinergic), ZMA (contains aspartate - analogue of glutamate, and B6 a cofactor)

Sedatives/Depressants: Picamilon (GABA analogue, B3 analogue which may cause indirect activation of benzodiazepine binding sites), Gotu Kola (induces GAD to make GABA from glutamate), Aniracetam (anxiolytic, cholinergic, glutamatergic), Ashwagandha (anxiolytic), Bacopa (raises serotonin, stabilizes dopamine), Phenibut (GABA analogue), L-Taurine (lowers BP, may bind to glycine sites), L-Theanine (GABA analogue), Lion's Mane (anxiolytic), Mirtazapine (an anxiolytic antidepressant that can treat insomnia), Lithium (mood stabilizer, raises serotonin and may be slightly sedating at even low doses)

See what I'm saying? Overall you just need to hone it down there maestro. I would take all sedatives at night and at lesser amounts as well as cycle things to avoid your body from "settling down" and adapting to these supplements. For instance, take Lion's Mane one month and Ashwagandha the next. Take picamilon one month and theanine the next. Green tea one month and quercetin the next. Lithium I think has to be taken long term to retain grey matter... so that might not be able to switch out. Obviously your prescriptions need to be taken as prescribed and would be too cumbersome for your doctor to take you on and off.

Also please keep in mind that flavonoids like Quercetin, EGCG, Resveratrol need a break in your diet. They inhibit various DNA functions like telomerase. During those times, you can take astragalus, gingko, and gotu kola to regrow your telomeres and clean up excess scar tissue. Some people report hair, eyes, nails, etc. to return to a younger state.

Please consider a reduction in stimulants that is manageable. Perhaps just a B Vitamin and some TMG will suffice along side of the dexedrine. Protein meals can give you phenylalanine and tyrosine. Racetams and ALCAR may actually make TS worse because they are glutamatergic and TS is thought to be caused (or reinforced) by overactive glutamate transport. Oxytocin treatment is a great break through in Asperger's research. Consider a deep massage therapy once a week and taking more oils in your diet.

My last word is that you need to find a stack that doesn't repeat itself and has an absolute "synergy".

Edited by devinthayer, 13 August 2011 - 08:05 AM.

[lourdaud]

Devinthayer: Whoooa.. that's extremely kind of you helping me out like that. Really really appreciate it.

I'll have to look further in to what you wrote and come back later, but I can at once say that I believe you're right in much of what you said about there being too much interference between all the ingredients in this cocktail. Lately I've been getting more anxious so I'll take it slower from here on I think.. The racetams are not giving me any anxiolytic effects anymore, or, maybe the Aniracetam does but it also makes me more socially awkward and spaced out and there also seem to be a rebound effect after a couple of hours.

As to the stimulant and downer mixing I can't fully agree with you. Sure, I probably have to titrate it better as I often feel spaced out, but overall I have to say that mixing downers and uppers really is my combo of choice. I will try to apply some of the restrictions and cycling you were hinting at though.

Once again, a huge thanks for all your help! will come back later

[lourdaud]

I have to add that I've started to reconsider my goals a bit. I really have to make more efforts in many areas of life that I've seriously been neglecting. Laughter and joy gets more and more uncommon and in a way I've kind of given up enjoyment and happiness.

It's not always been this way though, and still once a week my relief comes - that's when I take opiates. I can't describe how happy I feel and how many great things happen on these rare occasions. Yesterday was such a day and it was the best day in a long time, dated a nice girl all day long, eating-out, visiting some museums etc, and during the whole time I was socializing and enjoying the girls company in a way that simply is impossible for me when the opiate haze isn't there. These days always end with a huge smile on my lips, and I gratefully fall into sleep wishing every day would be like that. And then today there is the comedown and I feel even shittier than usual...

I get that this addictive behavior won't help me long-term. I want to change it to something more sustainable and I'm thinking Naltrexone. Those of you who are reading this and knows anything about Naltrexone, do you think that it might be the right choice for me? Might there be counteractions with the dexamphetamine? I get if Naltrexone ain't the best choice if you want to optimize cognition but the benefits might heavily outweigh any negative side-effects in my case I think..

[thedevinroy]

I have to add that I've started to reconsider my goals a bit. I really have to make more efforts in many areas of life that I've seriously been neglecting. Laughter and joy gets more and more uncommon and in a way I've kind of given up enjoyment and happiness.

It's not always been this way though, and still once a week my relief comes - that's when I take opiates. I can't describe how happy I feel and how many great things happen on these rare occasions. Yesterday was such a day and it was the best day in a long time, dated a nice girl all day long, eating-out, visiting some museums etc, and during the whole time I was socializing and enjoying the girls company in a way that simply is impossible for me when the opiate haze isn't there. These days always end with a huge smile on my lips, and I gratefully fall into sleep wishing every day would be like that. And then today there is the comedown and I feel even shittier than usual...

I get that this addictive behavior won't help me long-term. I want to change it to something more sustainable and I'm thinking Naltrexone. Those of you who are reading this and knows anything about Naltrexone, do you think that it might be the right choice for me? Might there be counteractions with the dexamphetamine? I get if Naltrexone ain't the best choice if you want to optimize cognition but the benefits might heavily outweigh any negative side-effects in my case I think..

Naltrexone is an opioid receptor antagonist (blocker) which may counteract addiction, but it will also worsen your AS. Consider taking an opioid agonist like time-release morphine, oxymorhpone, oxycodone, methadone, buprenorphine, or even Kratom if you like the herbal route.

[thedevinroy]

Devinthayer: Whoooa.. that's extremely kind of you helping me out like that. Really really appreciate it.

I'll have to look further in to what you wrote and come back later, but I can at once say that I believe you're right in much of what you said about there being too much interference between all the ingredients in this cocktail. Lately I've been getting more anxious so I'll take it slower from here on I think.. The racetams are not giving me any anxiolytic effects anymore, or, maybe the Aniracetam does but it also makes me more socially awkward and spaced out and there also seem to be a rebound effect after a couple of hours.

As to the stimulant and downer mixing I can't fully agree with you. Sure, I probably have to titrate it better as I often feel spaced out, but overall I have to say that mixing downers and uppers really is my combo of choice. I will try to apply some of the restrictions and cycling you were hinting at though.

Once again, a huge thanks for all your help! will come back later

Racetams increase receptor densities or sensitivities of NMDA and AMPA receptors. Since TS already has high activation of these receptors from higher glutamate transport, I would think that they might not help.

I don't know if anyone can really accurately predict the combination of so many stimulants and sedatives. That's why I suggested a decrease in complexity and volume so that you don't accidentally take too much or too little of one or the other. I enjoy the sedative stimulant combo as well, but sometimes you got to cut back and rely on your self more than substance. Besides the Dexedrine, the vitamins, and TMG, I don't see a need for extra stimulants if you eat enough protein and vegetables, especially since you have GAD.

And yes, please cycle the downers so that your system can be refreshed of monotony. Glad you liked that idea.

Are you taking enough magnesium? It's a natural calcium channel blocker and works pretty well alongside of Dexedrine to help out TS and ADHD which both are characteristic of low levels of magnesium.

Edited by devinthayer, 14 August 2011 - 01:20 AM.

[lourdaud]

How old are you exactly? Based on what I've read, resveratrol can have a negative affect on one's sexual maturation; so the advice was that he should not take it until he's 25. With the Lion's Mane, make sure the extract is from the mycelium. http://www.longecity...timulating-ngf/


This is the best I've found: http://www.iherb.com...Caps/21455?at=0

Hi Willou, thanks for your reply! Forgot to respond. Actually my bottle of resveratrol just ran out.. Still drink some wine every day, but what's the latest word on resveratrol? Would it be better to buy red wine extract? Could one expect cognitive benefits from higher doses of resveratrol? Heh, lots of questions, I'll look through the threads in the resveratrol forum..
Btw, metformin, is it considered safe and useful?

Lion's Mane - I bought this one: http://www.iherb.com...30-ml/2920?at=0
"Lion's Mane (Hericium erinaceus) fresh mycelia" Not good enough? I didn't know that Lion's Mane were anxiolytic before Devin mentioned it, I had only read about the NGF-promoting properties.. Don't think I've noticed anything though so maybe I've got a shitty bottle!!!

I got your message to give critique on this stack. I took a few glances at it and realized that I have to spend some serious thought into this, so I came back to it. What you have done is essentially taken everything. Yes, nootropics are cool, but rarely should they be used in mass quantities and varieties by one individual. It's a bit overboard. For more specific things....

• TMG may keep you up an night or help you wake up, depending on the type of person you are.
• Forskolin may counteract the focus-effects of Dexedrine. It is the flagship of raising cAMP levels. cAMP is no so good for the ADHD pre-frontal cortex.
• GABA by itself cannot cross the blood-brain barrier. Consider instead herbs that increase GABA: lemon balm, gotu kola, and valerian root. Or picamilon which you already take.
• Silymarin itself is not that bioavailable due to the harsh environments in you stomach. Consider taking in a timed release form.

I don't take the TMG at night anymore. Instead I've added an extra dose of ALCAR three hours before bed to help a bit with the dex-comedown, and also because I hope that it will improve sleep and maybe even require less of it..! (although I doubt that a bit but who knows)
NOOO, wtf, what you say about the Forskolin and cAMP really sucks!! I bought it for the very reason of taking Dex as Forskolin supposedly lowers blood pressure. I don't understand very much of this "cAMP" but I notice a few studies showing that decreasing this cAMP-activity increases PFC-activity. As I hate wasting and want to finish the bottle that I'll receive, what do you think about taking the Forskolin before bed? Preferably with the mirtazapine which always increase my appetite.. i.e. does Forskolin permanently, or at least during a longer period of time, raise cAMP levels, or does it only last when it's in your system? Heck if that's the case, maybe it's even good; lowering cAMP levels during the day?!

Sooome GABA crosses the BBB, no? I'm asking as I believe it makes me somewhat relaxed and also I seem to wake up in the middle of sleep on the nights where I've taken it before bed.. or could that maybe rather be muscle-relaxation-related or am I just imagining?
Valerian root I don't like, makes me fuzzy in a weird way. Gotu kola and Reishi will be added though, and the Ashwagandha, Bacopa and Lion's Mane will be night-time only. Oh, and I love Picamilon, especially in a higher dose where it seem to clear my mind. Irritating that the effect seem to vanish so quickly though, imagine it lasting the whole day..!
Sad to hear about the Silymarin, didn't know that. Will use up the bottle, after that I want to try Curcumin anyway which may have some similar properties if I got it right.. heh, one couldn't let the Silymarin dissolve under the tongue then???

I find it strange that you mix stimulants with sedatives... I've done it before when I was taking a lot of over-the-counter stimulants, but ultimately I found it extremely hard to regulate the proper combination to achieve a consistent energy level. The stimulants would wear you down time after time of repeated administration and you wouldn't know if you took too much or too little until they wore off. When they wore off, some sedating effects were still around and the crash was even more intense. Please look at the effects of each supplement and consider their effectiveness, duration, and optimal time to take it a little bit further.

Stimulants: Dexedrine (NDRI), Green Tea (adenosine blocker, COMT inhibitor), TMG (methyl donors), B Vitamins (cofactors), Piracetam and Oxiracetam (cholinergic, glutamatergic), ALCAR (cholinergic, glutamatergic, metabolic enhancer), tyrosine (precursor), Quercetin (MAOi, COMT inhibitor), Forskolin (PDE inhibitor), Gingko Biloba (NET inhibitor), Pyritinol (cofactor), DMAE (cholinergic, methyl doner), phenylalanine (precursor), Sulbutiamine (DRI, also indirectly releases DA as thiamine polyphosphates), ALA (metabolic enhancer), Lecithin (cholinergic), ZMA (contains aspartate - analogue of glutamate, and B6 a cofactor)

Sedatives/Depressants: Picamilon (GABA analogue, B3 analogue which may cause indirect activation of benzodiazepine binding sites), Gotu Kola (induces GAD to make GABA from glutamate), Aniracetam (anxiolytic, cholinergic, glutamatergic), Ashwagandha (anxiolytic), Bacopa (raises serotonin, stabilizes dopamine), Phenibut (GABA analogue), L-Taurine (lowers BP, may bind to glycine sites), L-Theanine (GABA analogue), Lion's Mane (anxiolytic), Mirtazapine (an anxiolytic antidepressant that can treat insomnia), Lithium (mood stabilizer, raises serotonin and may be slightly sedating at even low doses)

See what I'm saying? Overall you just need to hone it down there maestro. I would take all sedatives at night and at lesser amounts as well as cycle things to avoid your body from "settling down" and adapting to these supplements. For instance, take Lion's Mane one month and Ashwagandha the next. Take picamilon one month and theanine the next. Green tea one month and quercetin the next. Lithium I think has to be taken long term to retain grey matter... so that might not be able to switch out. Obviously your prescriptions need to be taken as prescribed and would be too cumbersome for your doctor to take you on and off.

Also please keep in mind that flavonoids like Quercetin, EGCG, Resveratrol need a break in your diet. They inhibit various DNA functions like telomerase. During those times, you can take astragalus, gingko, and gotu kola to regrow your telomeres and clean up excess scar tissue. Some people report hair, eyes, nails, etc. to return to a younger state.

Please consider a reduction in stimulants that is manageable. Perhaps just a B Vitamin and some TMG will suffice along side of the dexedrine. Protein meals can give you phenylalanine and tyrosine. Racetams and ALCAR may actually make TS worse because they are glutamatergic and TS is thought to be caused (or reinforced) by overactive glutamate transport. Oxytocin treatment is a great break through in Asperger's research. Consider a deep massage therapy once a week and taking more oils in your diet.



My last word is that you need to find a stack that doesn't repeat itself and has an absolute "synergy".

Thanks for the links, interesting. Oxytocin really is interesting but unfortunately it's expeeensive, and the effect seems to be really fleeting. Wonder if "Way-267464" will (is? anyone?) be cheaper? Hope all the fats and oils I eat because of my keto diet helps! Mirtazapine is also supposed to increase Oxytocin through some of its actions I think. Wouldn't pay for a massage but hopefully I'll find a girl kind enough one day haha.

The ALCAR I would never ditch!! It's one of my favorite supps, I love all the energy, clear thinking and especially the morning boost I get from it! plus all the other health and mind related benefits.. Maybe I notice such an improvement as I don't eat very much protein because of the keto diet.
Will try to skip it one day to see if that makes me less anxious though.. (heh, that reminds me, haven't skipped it one day I think since I started taking it six months ago..)
I don't notice much at all from TMG but maybe it would be a good idea replacing the lunch dose of ALCAR with it, always get anxious at that time when the anti-histamine properties of Mirtazapine seem to wane off.

Naltrexone is an opioid receptor antagonist (blocker) which may counteract addiction, but it will also worsen your AS. Consider taking an opioid agonist like time-release morphine, oxymorhpone, oxycodone, methadone, buprenorphine, or even Kratom if you like the herbal route.

Oh, I should have mentioned, it's LDN that I consider! You certainly know of it but a low dose (~1,5 - 4,5 mg) of Naltrexone before bed will trick the body to produce a lot more endorphin when the Naltrexone has been eliminated.. Made an order yesterday at alldaychemist, really really hoping for this one! However I'm starting to regret a bit that I didn't order some Memantine as well.. would maybe sync nicely with the dex and Naltrexone, might be a good idea, school coming up and all. Do you have any thoughts on this?

Racetams increase receptor densities or sensitivities of NMDA and AMPA receptors. Since TS already has high activation of these receptors from higher glutamate transport, I would think that they might not help.

I don't know if anyone can really accurately predict the combination of so many stimulants and sedatives. That's why I suggested a decrease in complexity and volume so that you don't accidentally take too much or too little of one or the other. I enjoy the sedative stimulant combo as well, but sometimes you got to cut back and rely on your self more than substance. Besides the Dexedrine, the vitamins, and TMG, I don't see a need for extra stimulants if you eat enough protein and vegetables, especially since you have GAD.

And yes, please cycle the downers so that your system can be refreshed of monotony. Glad you liked that idea.

Are you taking enough magnesium? It's a natural calcium channel blocker and works pretty well alongside of Dexedrine to help out TS and ADHD which both are characteristic of low levels of magnesium.

The increased brain activity that I've seen from Piracetam, if there even is one, doesn't seem to be in the TS way.. just better thinking.. The Aniracetam on the other hand really does seem to make my thoughts spin, in a both good and bad way.. seems to improve logical reasoning and verbal fluency but I get really really impatient. Maybe lowering the Piracetam dose and leaving Aniracetam for busy days might be a good idea.

I take ZMA twice a day, at night and at lunch. Really curious in magnesium-l-threonate but I'll wait for more reports as it's a bit expensive.. Think I'll add a potassium supp as low levels has been seen from that as well in individuals with ADHD IIRC.. Hope I get enough B's and hope all the green tea I drink don't mess with their absorption (EGCG interferes with some enzyme responsible for folate uptake or something like that??)