3 replies to this topic

[Shevardin]

We know how the expression of genes changes during C.Elegans ageing. [1]
We know how different medicine changes this expression.
We know some biomarkers of ageing and if we improve them we can say we've made C.Elegans younger.
So there is no problem at all: we need just to make experiments with different geroprotectors [quercetine, reveratrol and other] and to choose such their combination which is most appropriate for rejuvenation.

The same can be done with mices.

[kmoody]

There are some who agree with you in principle. The most established group I'm aware of that is doing this is the company Genescient (http://www.genescient.com/). Their work is based off of the Methuselah flies rather than C. Elegans, but same idea.

[treonsverdery]

I once read a list of which genes are most conserved between species, like the cytochrome C genes is nearly identical between yeast n people
thus going with longevity treatments that effect the expression of the most conserved genes would be preferred as these treatments effect the largest number of species thus are likely to effect humans as well

Edited by treonsverdery, 01 February 2012 - 05:48 AM.

[brokenportal]

Flesh this out, if nothing else the discussion can be beneficial, and at best you might even inspire somebody to put the project together. I would love to see a longevity gene expression research fundraiser here at Longecity. I'll move this to bio-science for now. If a research project proposal ever comes of it then we can move it back.