What I took today:
3:00 2-5 mg of L-Lysine (as much as stuck to my finger when sticking it in the tub).
This put me to sleep for the rest of the night, but my anxiety remained high. Lysine dreams are always vivid for me.
7:00 2-5 mg of Citrulline Malate
This neutralized my anxiety, but also seemed to cause neuro-inflammation. Before I took it, my frontal lobe felt especially good due to the earlier Lysine supplementation. This is interesting, because the first time that I took Lysine (years ago) I took around 500 mg and it gave me an extreme migraine behind my eyes that was difficult to reduce.
7:30 2-5 mg of L-Lysine
I took this to help balance any negative effects from the citrulline. It seemed to work, and I later noticed an above average alertness and visual clarity with little felt averse effect from earlier.
Lysine seems to have the barbiturate effect that it is linked to (given the above and prior experiences with it), which can be anxiety reducing through what seems to be a sedative effect.
However, I find that subsequent low doses, to the first dose, seem to lead to rebound anxiety. If its not rebound anxiety, then I can definitely state that Lysine is not anxiolytic on its own long term. I took it last night in an attempt to quell nighttime anxiety and, while it put me to sleep, my anxiety remained high. One way around this possible rebound effect might be to take ever higher doses of Lysine that will suppress any possibility of immediate rebound. Currently, I'm still In the low dose experimentation phase. Again, Lysine worked to quell anxiety the first couple of times at a low dose, and then it did not.
What did quell the anxiety, which Lysine either failed to stop on its own or perhaps made worse through the rebound effect, was a small dose of citrulline malate (which creates arginine and NO).
Because I took it after I took Lysine, I can not state to know whether citrulline would have had this anxiety quelling effect in the absence of recent Lysine supplementation, but I do remember a measure of emotional stabilization when taking it on its own in the days prior.
I've been taking these two substances (Lysine and Citrulline) apart, with the goal of becoming familiar with their effects on their own. Gradually, I am moving toward taking them together as per the well known anxiety remedy (only substituting citrulline for arginine, though I will soon buy some L-Arginine).
My first citrulline dose had fairly amazing effects on vascularization.
After the first dose, that is not nearly as noticeable. In fact, this morning, I thought that I had noted a measurable inflammation effect in my brain (I'm sensitive due to certain neurological conditions). This would have been the NO.
The anxiety was still neutralized, but the inflammation was present.
Because lysine reduces NO, I then took another small dose of Lysine, which seemed to even things out and compliment the citrulline. My later felt experience is included in the timeline. I would categorize both it and my earlier commented on experience in regard to my frontal lobe feeling, upon waking, as "nootropic" in a well-above average manner.
More experimentation is required. It is obvious that Arginine / Citrulline and Lysine compliment one another, and may even be required for optimal effects. What is required is to flesh out optimum doses, frequency, and timing of this stack.
Right now, my anxiety is still low.