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Lysine as a nootropic?

lysine nootropic

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#1 Baten

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Posted 02 February 2012 - 06:34 PM

I've recently started taking lysine tablets after meals twice a day (2g afternoon 2g evening) and I've strangely noticed:
subtly better attention, motivation, subtly feeling sharper with better recall.

I've been taking 25 mg zinc picolinate twice a day & 5000IU vitD3 every other day along with it (added the lysine only recently).

I bought the tablets just to mess around, since zinc+lysine supposedly raises sperm volume (bigger load =stronger orgasms, lol),
but I'm quite surprised with the noticeable effects on cognition.

Definitely adding the zinc+lysine combo to my daily stack. Really gives me a calm and sharp boost throughout the day for some reason.
The 2g dose is probably overkill though, will probably drop down to 1 tablet twice a day after a while.

Found this on the matter. No idea about its credibility though.

"The present invention shows that administration of L-lysine enhances cognitive performance in healthy individuals directly and these improvements persist if L-lysine is continuously administrated.
However, when administration is interrupted the cognitive performance returns to baseline."

Edited by Baten, 02 February 2012 - 06:42 PM.

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#2 pedr0vsky

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Posted 02 February 2012 - 10:06 PM

L-Lysine is used to is post surgery patients to speed up tissue healing and strengthen tissue. It made it difficult to sting my buttock when i was on cerebrolysin.

It didn't work as a nootropic for me, though...

Edited by pedr0vsky, 02 February 2012 - 10:17 PM.

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#3 kevinseven11

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Posted 03 February 2012 - 12:59 AM

Lysine Inhibits 5-ht4 receptor in the gut but also the CNS. 5 ht4 seems to increase cAMP so this is not the mechanism. Perhaps less activity in the gut can reduce anxiety which leads to clearer thinking?

#4 Lufega

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Posted 03 February 2012 - 01:20 AM

Agree with kevin. Less anxiety, clearer thinking and we already know that lysine reduces anxiety. Lysine is also a precursor to Carnitine. So maybe more Lysiny = More Carnitine and that explains the effect.

#5 medievil

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Posted 19 April 2012 - 10:24 AM

It also looks promising for shizophrenia.

L-lysine as adjunctive treatment in patients with
schizophrenia: a single-blinded, randomized,
cross-over pilot study
Caroline Wass
, Daniel Klamer
, Evangelos Katsarogiannis
, Erik Pålsson
, Lennart Svensson
, Kim Fejgin
Inga-Britt Bogren
, Jörgen A Engel
and Birgitta Rembeck
Background: Accumulating evidence suggests that the brain’s nitric oxide (NO) signalling system may be involved
in the pathophysiology of schizophrenia and could thus constitute a novel treatment target. The study was
designed to investigate the benefit of L-lysine, an amino acid that interferes with NO production, as an add-on
treatment for schizophrenia.
Methods: L-lysine, 6 g/day, was administered to 10 patients with schizophrenia as an adjunctive to their
conventional antipsychotic medication. The study was designed as a single-blinded, cross-over study where
patients were randomly assigned to initial treatment with either L-lysine or placebo and screened at baseline, after
four weeks when treatment was crossed over, and after eight weeks.
Results: L-lysine treatment caused a significant increase in blood concentration of L-lysine and was well tolerated.
A significant decrease in positive symptom severity, measured by the Positive And Negative Syndrome Scale
(PANSS), was detected. A certain decrease in score was also observed during placebo treatment and the effects on
PANSS could not unequivocally be assigned to the L-lysine treatment. Furthermore, performance on the Wisconsin
Card Sorting Test was significantly improved compared to baseline, an effect probably biased by training.
Subjective reports from three of the patients indicated decreased symptom severity and enhanced cognitive
Conclusions: Four-week L-lysine treatment of 6 g/day caused a significant increase in blood concentration of
L-lysine that was well tolerated. Patients showed a significant decrease in positive symptoms as assessed by PANSS
in addition to self-reported symptom improvement by three patients. The NO-signalling pathway is an interesting,
potentially new treatment target for schizophrenia; however, the effects of L-lysine need further evaluation to
decide the amino acid’s potentially beneficial effects on symptom severity in schizophrenia.

#6 medievil

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Posted 19 April 2012 - 11:15 AM

Hmm wasnt aware zinc with lysine raises sperm volume that with clomid should be impressive haha; ill research what else does this so i can really blow my girl away haha.

#7 Baten

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Posted 20 April 2012 - 08:37 AM

Hmm wasnt aware zinc with lysine raises sperm volume that with clomid should be impressive haha; ill research what else does this so i can really blow my girl away haha.

Some girls don't like that too much, though :P

As a little update, I'm now take lysine+zinc away from meals. On workdays 2g in the morning 1g in the afternoon, weekends 2g in the afternoon 1g in the evening.
For the cheapest zinc solution I bought NOW 50mg zinc picolinate, open a cap and divide it in roughly 2 equal doses to take with the lysine.
Have to say this is one of my favorite supplements next to lithium orotate which stabilizes mood and reduces irritability (1 tablet of doctor's best brand with lunch).

Edited by Baten, 20 April 2012 - 08:38 AM.

#8 Ames

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Posted 24 March 2017 - 04:08 PM

What I took today:


3:00 2-5 mg of L-Lysine (as much as stuck to my finger when sticking it in the tub).


This put me to sleep for the rest of the night, but my anxiety remained high. Lysine dreams are always vivid for me.


7:00 2-5 mg of Citrulline Malate


This neutralized my anxiety, but also seemed to cause neuro-inflammation. Before I took it, my frontal lobe felt especially good due to the earlier Lysine supplementation. This is interesting, because the first time that I took Lysine (years ago) I took around 500 mg and it gave me an extreme migraine behind my eyes that was difficult to reduce. 


7:30 2-5 mg of L-Lysine


I took this to help balance any negative effects from the citrulline. It seemed to work, and I later noticed an above average alertness and visual clarity with little felt averse effect from earlier.


Lysine seems to have the barbiturate effect that it is linked to (given the above and prior experiences with it), which can be anxiety reducing through what seems to be a sedative effect.


However, I find that subsequent low doses, to the first dose, seem to lead to rebound anxiety. If its not rebound anxiety, then I can definitely state that Lysine is not anxiolytic on its own long term. I took it last night in an attempt to quell nighttime anxiety and, while it put me to sleep, my anxiety remained high. One way around this possible rebound effect might be to take ever higher doses of Lysine that will suppress any possibility of immediate rebound. Currently, I'm still In the low dose experimentation phase. Again, Lysine worked to quell anxiety the first couple of times at a low dose, and then it did not.


What did quell the anxiety, which Lysine either failed to stop on its own or perhaps made worse through the rebound effect, was a small dose of citrulline malate (which creates arginine and NO).


Because I took it after I took Lysine, I can not state to know whether citrulline would have had this anxiety quelling effect in the absence of recent Lysine supplementation, but I do remember a measure of emotional stabilization when taking it on its own in the days prior.


I've been taking these two substances (Lysine and Citrulline) apart, with the goal of becoming familiar with their effects on their own. Gradually, I am moving toward taking them together as per the well known anxiety remedy (only substituting citrulline for arginine, though I will soon buy some L-Arginine).


My first citrulline dose had fairly amazing effects on vascularization.


After the first dose, that is not nearly as noticeable. In fact, this morning, I thought that I had noted a measurable inflammation effect in my brain (I'm sensitive due to certain neurological conditions). This would have been the NO.


The anxiety was still neutralized, but the inflammation was present.


Because lysine reduces NO, I then took another small dose of Lysine, which seemed to even things out and compliment the citrulline. My later felt experience is included in the timeline. I would categorize both it and my earlier commented on experience in regard to my frontal lobe feeling, upon waking, as "nootropic" in a well-above average manner. 


More experimentation is required. It is obvious that Arginine /  Citrulline and Lysine compliment one another, and may even be required for optimal effects. What is required is to flesh out optimum doses, frequency, and timing of this stack.

Right now, my anxiety is still low.

#9 PeaceAndProsperity

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Posted 24 March 2017 - 05:54 PM

L-lysine does something with glutamate, mglur receptors in paticular. It seems to activate the mglur5 receptors. This could be a very indirect effect simply through raising glutamate itself (like caffeine does).

#10 Ames

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Posted 24 March 2017 - 07:20 PM

And later in the day I'm crashing quite a bit. It feels like the crash from a stimulant - I assume glutamate.


The only other time I really feel like this is when I take a small amount of Magnesium threonate, which causes me to need a nap around 6 pm like clockwork. Though, the MagThreonate crash comes on faster and stronger; perhaps from a critical concentration in the brain that blocks the NMDA / glutamate receptor (unsure). This is more like prolonged lethargy. I assume that this is from the Lysine, but it also might be from the earlier anxiety impaired sleep. I'll keep mixing up the timing of these two supplements to flesh out exactly what is occurring with both.


Though, it is also worthy to not that I have a certain inflammatory neuropathology that could be credibly concluded to cause me to act irregularly to supplements. My reactions are sometimes either much less or more to supplements than the reactions that others may perceive for themselves. I'm a non-responder to some supps, and have sensitive responses to others. 

Edited by golgi1, 24 March 2017 - 07:22 PM.

#11 PeaceAndProsperity

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Posted 24 March 2017 - 07:36 PM

Try the lysine with a  couple grams of creatine. If the creatine negates the positive effects of the lysine then you can say with certainty it's due to glutamate, since creatine lowers glutamate via transporter competition.

#12 gamesguru

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Posted 25 March 2017 - 02:42 PM

as with most of the stuff out there that has any effect at all, i've read and agreed with the statement that it has horrendous tolerance issues after just a few days.  as for its effects, wouldn't quite describe it as a stimulant or uplifting but it is known to reduce anxiety and cortisol, to facilitate the conversion of blood sugar to glycogen (without affecting insulin), and to be involved in cell growth/division (particularly of collagen and soft tissues).  So it definitely has 'energizing' effects.  It's also anti-herpetic, you can take it as a pill or apply it as a cream.   Keep in mind 98% of adults carry hsv1 or 2.  Oddly enough the anxiety study featured it with arginine, but for herpes that's going to put you back in the red.  Arginine catalyzes its intranuclear replication and it serves like bricks in a building as a convenient building block for the viral coating or proteal skeleton.


It's interesting that another study reports an increase in insulin and IGF-1 after taking lysine in association with increased methylation and acetylation / histone gene expression.  They used a higher dose and if you read the full study even discuss the potential for deficiency and toxicity.  Once again kids, get it from your diet.  I have a bottle of like 200 or 300 lysine tabs that I barely touch only if i eat really light that day.  It's more of a dust collector, as it should be

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#13 Keizo

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Posted 26 March 2017 - 02:22 AM

When I have taken lysine, 500-2000mg, it certainly does something with how I feel and behave, but I wouldn't say that it is too noticeable nor does it seem reliable. But considering what it is, I would imagine it is among the most safe things to test.

I wouldn't say it is predominantly stimulating, nor predominantly relaxing, sometimes it seems to have made me agitated but at other times more relaxed. However when I have taken it at night it seems to actually prevent sleepiness.

Edited by Keizo, 26 March 2017 - 02:47 AM.

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