17 replies to this topic

[medievil]

-----Depression-----

Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression.http://www.ncbi.nlm....pubmed/19632285

[Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress].http://www.ncbi.nlm....pubmed/21837980

Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors http://www.ncbi.nlm....pubmed/21424694

The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression.http://www.ncbi.nlm....pubmed/21273053



-----Adaptive changes induced by reinforcing drugs

Inhibiting adaptive changes by morphine Wild ginseng attenuates repeated morp... [J Microbiol Biotechnol. 2011] - PubMed - NCBI
Inhibitory effects of ginseng total saponin o... [Arch Pharm Res. 2008] - PubMed - NCBI
As a bonus reverses impaired learning, why learn while enjoying a nod tough Ginsenoside Rg1 restores the impairment of... [J Psychopharmacol. 2009] - PubMed - NCBI

How panax blocks adaptive changes and damage of several substances Pharmacological action of Panax ginseng on th... [Arch Pharm Res. 2005] - PubMed - NCBI

Blocks sensitization to meth and again another showing morphine tolerance slowing [Pharmacological and physiological e... [Nihon Yakurigaku Zasshi. 2001] - PubMed - NCBI

Inhibits morphine cpp Effects of ginseng total saponin on morphin... [J Ethnopharmacol. 1998] - PubMed - NCBI

Blocks reverse tolerance too no idea wheter that really occurs in humans like sensitization, i did experience simular things to drugs Inhibition by ginseng total saponin of the dev... [Gen Pharmacol. 1995] - PubMed - NCBI

The effect of Panax ginseng on the development... [Gen Pharmacol. 1991] - PubMed - NCBI

High doses antagonize morphine:
Antagonism of the acute pharmacological action... [Gen Pharmacol. 1990] - PubMed - NCBI

cpp coke and meth
The effect of ginseng extract on loc... [Pharmacol Biochem Behav. 1996] - PubMed - NCBI

-----Erectile function

Study showing significant improvement http://www.ncbi.nlm....pubmed/19234482
Im assuming here red ginseng is the same as panax ginseng http://www.ncbi.nlm....pubmed/18754850
http://www.ncbi.nlm....pubmed/16855773
http://www.ncbi.nlm....pubmed/12540305
http://www.ncbi.nlm....pubmed/12394711
http://www.ncbi.nlm....pubmed/10492246

----Cardiovascular

http://www.ncbi.nlm..../pubmed/8886498
Thats it for today, tomorrow il put some shit togheter of its other benefits.

--- Inflammation

Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation. http://www.ncbi.nlm....pubmed/21600888

Effects of Panax ginseng supplementation on muscle damage and inflammation after uphill treadmill running in humans.http://www.ncbi.nlm....pubmed/21598413

Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model. http://www.ncbi.nlm....pubmed/21549818

Interaction between COX-2 and iNOS aggravates vascular lesion and antagonistic effect of ginsenoside. http://www.ncbi.nlm....pubmed/18694814

More to find; posting this as it hasnt been discussed much.

[kevinseven11]

ginseng also seems to be a choline uptake enhancer, just as colouractam. Very rare find https://docs.google....2pesJVamg&pli=1
:)I added this to wiki

Edited by kevinseven11, 12 May 2012 - 05:36 AM.

[medievil]

Damn can never post in normal font here.

[gizmobrain]

Good to see some discussion, as I just randomly purchased a Ginseng Complex from the Vitamin World outlet the other day. It has American, Red Chinese, and Panax Ginseng extract, as well as eleuthero and royal jelly. It was cheap and I had been hearing some stuff about ginseng and memory, so I thought I'd pick up a bottle.

Definitely curious to see how this Ginseng + CILTEP stack (+ Magnesium L-Threonate at night) plays out. I would love to see an improvement in all aspects of my memory.

Edited by zrbarnes, 12 May 2012 - 05:51 AM.

[medievil]

It modulates glutamate trough PKA; may synergize with compounds that modulate glut trough pkc like nefi.

[niner]

Damn can never post in normal font here.

In the upper left hand corner of the editor, there is an obscure little icon that is supposed to look like a light switch. If you click it, it will toggle the editor into a plain vanilla mode where you can see what's going on. If you enter text in the plain mode, you probably will not have a problem. I use it when I paste in stuff from other sites so that I don't get all the formatting and links carried over. Once you've entered, you can toggle back to see what it will look like when it's posted.

By the way, what kind of hardware/software are you using? Something is messed up...

Edited by niner, 12 May 2012 - 10:41 AM.

[medievil]

lol its my keyboard the n is broken so i ctrl v; i got used to it and too lazy to get it replaced

[niner]

Try the plain text mode. It should work..

[medievil]

Lets hope so pal im giving everyone headaches with my posts haha; so lets see...

[medievil]

Im retrying ginseng atm; i threw out nac as it appeared to make my anhedonia worse; will keep yall updated. Its also a 5HT2A agonist like aniracetam.

Edited by medievil, 12 May 2012 - 04:53 PM.

[medievil]

Ill try to fuck on it; mpa gives me a limp dick and it should help erectile function.

[medievil]

Modulatory effect of ginseng on neurotransmission
A number of studies have shown that some ginsenosides can modulate neurotransmission in the brain.
Ginsenosides Rb1 and Rg1, the most abundant ginsenosides in ginseng root, can modulate acetylcholine release
and re-uptake and the number of choline uptake sites,
especially in the hippocampus (54). They also increase
choline acetyltransferase levels in rodent brains (35, 55).
These results suggested that these compounds may
improve central cholinergic function in humans and may
be used to treat memory deficit (36). It has also been
reported that ginsenosides increased dopamine and
norepinephrine in the cerebral cortex (56), which may
explain the favorable effects of ginseng extract upon
attention, cognitive processing, integrated sensorymotor function, and auditory reaction time in healthy
subjects (57). Additionally, it has been shown that
ginseng total saponins can modulate dopaminergic
activity at both pre-synaptic and post-synaptic receptors
(58); and they can block behavioral sensitization
induced by psychostimulants such as morphine (59),
cocaine (58), methamphetamines (60), and nicotine
(61 – 63). Furthermore, it was found that ginseng
increased serotonin in the cortex (64), ginseng saponins
raised the levels of biogenic amines in normal rat brain
(65), ginsenoside Rg2 directly interacted with nicotinic
receptor subtypes (66), and ginseng administration lead
to regulation of GABAergic transmission in animals
(67, 68).


Some interesting info:
http://bemri.com/app...ve disorders (1).pdf

[Ampa-omega]

ginseng also seems to be a choline uptake enhancer, just as colouractam. Very rare find https://docs.google....2pesJVamg&pli=1
:)I added this to wiki

the racetams pir,oxi,ani do as well.. coluracetam is mentioned as a high affinity choline uptake enhancer.

Edited by Ampa-omega, 13 May 2012 - 08:51 AM.

[Ampa-omega]

Im retrying ginseng atm; i threw out nac as it appeared to make my anhedonia worse; will keep yall updated. Its also a 5HT2A agonist like aniracetam.

would it be safe to megadose ginseng? im interested in what would result.

[medievil]

Erectile dysfunctioning caused by mpa improved alot with ginseng but my dick was still folding dubbel when i tried to get in so its not the golden bullet but great improvement; also lexapro makes me last long great sexstack if i could get in atleast.

not sure i havent researched the toxiticy but im pretty sure it would be safe.

[Ampa-omega]

Im retrying ginseng atm; i threw out nac as it appeared to make my anhedonia worse; will keep yall updated. Its also a 5HT2A agonist like aniracetam.

would it be safe to megadose ginseng? im interested in what would result.

the effects on morphine, cocaine and amphetamine sensitization are really interesting, i wonder how ginseng would combine with ibogaine.

[kevinseven11]

So is it possible that Ginseng works with Kappa Opoid receptor?

[medievil]

Im retrying ginseng atm; i threw out nac as it appeared to make my anhedonia worse; will keep yall updated. Its also a 5HT2A agonist like aniracetam.

would it be safe to megadose ginseng? im interested in what would result.

the effects on morphine, cocaine and amphetamine sensitization are really interesting, i wonder how ginseng would combine with ibogaine.

Hmm well ibogaine does all that too if im correct.