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What can stop the production of melatonin?


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#1 stablemind

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Posted 14 May 2012 - 06:29 PM


I know now that melatonin production is a large cause of jet lag feeling and ultimately my BPD. Lithium helps regulate this to an extent, but I feel that whenever I stay awake past 4PM my circadian rhythm shifts forward. Is there anything besides bright light that can suppress melatonin production in the morning?

Melatonin antagonists include:



At night, a small dose of melatonin can be prepared to prepare the onset of melatonin production when one will stay awake late, to prevent the cycle from being disrupted.

Edited by stablemind, 14 May 2012 - 06:31 PM.


#2 Lufega

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Posted 15 May 2012 - 10:16 PM

How do you know melatonin is the culprit ? Apologies if the answer is obvious.

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#3 nupi

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Posted 17 May 2012 - 12:39 PM

IIRC, Agomelatine should be an agonist rather than an antagonist. And Wiki agrees:
"Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist."

#4 jadamgo

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Posted 25 May 2012 - 05:18 AM

Those are all agonists. I'm not aware of any antagonists, so you'll have to make do with stopping the melatonin release. That means bright light, and certain stimulants. I don't think coffee is strong enough to stop melatonin production, but a noradrenergic stimulant like pseudoephedrine ought to do the trick. Ritalin works fine for me, but you probably don't have a prescription for that.

Beware that lithium does not advance the circadian rhythm, it delays it. That's why it's a stronger anti-manic than anti-depressant in bipolar disorder; it makes sure they're sleeping enough to avoid mania.

EDIT: Uhh, I guess you probably meant BiPolar Disorder, not Borderline Personality Disorder if you're on lithium. Which means you aren't supposed to use bright light in the morning, or you'll get mania (or mixed depression, which is no better). But you CAN use bright light at midday whenever you're depressed or euthymic. Unfortunately, that does nothing for your circadian rhythm, unless you stick to a rigid schedule of doing it at the same time every day. Then it would advance your phase when you're delayed, and delay it when you're advanced.

Do watch out for the stimulants. I'm not a big believer in stimulants truly CAUSING mania, but they can enable you to become manic by giving you the energy to do too much and sleep too little. Modafinil seems not to cause too many problems for bipolar people, though. And I live with a bipolar I person who occasionally takes ritalin, though she uses it for OCD symptoms, not ADHD or depression. (I can't belive that works. Ritalin makes me more obsessive, which is why it helps me focus more. But evidently it increases her self-control enough to break free from circular thinking.)

Edited by jadamgo, 25 May 2012 - 05:24 AM.


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#5 magta39

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Posted 25 May 2012 - 08:15 PM

I read a study years ago where researchers were giving beta blockers to mice to block production of melatonin....there were studying the effects of melatonin on cancer




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