34 replies to this topic

[ScientiaPotentiaEst]

Thank you for writing the update! You didn't happen to set up a multivariate analyse in order to isolate  the relationships and dynamics between the substances used and their affects.
Also, I noticed you used Uridine. Was this uridine-5'-monophospate (UMP) or triacetyluridine (TAU)?

[cjgymrat]

Do you believe the low-dose lexapro imparted any nootropic/ neuroregenerative effects? Is there anything about escitalopram's mechanism of action which caused you to favor it over other potential SSRI's?

[khemix]

cjgymrat, on 07 December 2012 - 07:27 PM, said:

Do you believe the low-dose lexapro imparted any nootropic/ neuroregenerative effects? Is there anything about escitalopram's mechanism of action which caused you to favor it over other potential SSRI's?

I took it strictly based on the theoretical notion that serotonin aids in neurogenesis. I noticed it impaired a form of "flash memory" - the exercise flashes a number of pictures for a split second and you're supposed to count them all up in your head -  SSRIs impaired this task. I favored escitalopram because of its "clean" pharmacology, it affects very few other receptors outside the SERT transporter. However experience has shown me it is not good, and I even think it has anti-histmaine properties (H-1) which are not good for cognition. The best SSRI by far is Zoloft (sertaline) in terms of how I tolerate it, its very clean too, and gives some dopamine reuptake. There was some benefit on SSRIs, as they cleaned up the internal chatter which could sometimes be distracting. Ideally I would like an SSRI with a half life less then 12 hours, which Straterra actually has as it blocks SERT. Strattera is actually amazing, it has a 5-hour half-life and interesting profile... on it I felt like my frontal lobe was dancing (some kind of high?) and I was absolutely sharp and motivated. I was a sponge for knowledge... I absorbed everything around me, paying attention required zero effort, and I felt great. Unfortunately this runs out after 3 days of consecutive use and taking it causes lethargy - no doubt by a-2 autoreceptors - but sporadically you can retain some of the magic. Just use low doses, no more than 40mg.  It's also bloody expensive.

ScientiaPotentiaEst, on 06 October 2012 - 12:41 PM, said:

Thank you for writing the update! You didn't happen to set up a multivariate analyse in order to isolate  the relationships and dynamics between the substances used and their affects.
Also, I noticed you used Uridine. Was this uridine-5'-monophospate (UMP) or triacetyluridine (TAU)?

UMP.

I'll have a much better report on things within a year, trying a lot of interesting things. In particular indirectly activating the frontal-lobe with specific 5-HT antagonists, clogging D2 autoreceptors, etc.

Until then I advise you to n-back. I would bet my life on it - it is not placebo. It must be done properly however.

Edited by khemix, 08 December 2012 - 07:56 PM.

[samuilov]

I like your methods and ideas would you happen to have some new updates on the matter?

[clockwatcher]

Any updates OP?