More from wiki:
"
TauRx Therapeutics has reported that methylene blue (methylthioninium chloride), under the tradename
Rember, may provide a way of halting or slowing the progression of Alzheimer's dementia.
[38] However, the formulation used was different from that commonly available as a medicine and caution has been expressed about use of methylene blue as a treatment for Alzheimer's.
[39] TauRx Therapeutics has suggested that the mechanism by which methylene blue might delay or reverse neurodegeneration in Alzheimer's disease is as an inhibitor of
Tau protein aggregation. While methylene blue arguably has an effect on Tau aggregation, it has been shown to have a great effect in dissociation of amyloids
[40] and also has an effect on mitochondrial function which are both likely targets that result in its therapeutic effect. In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key
mitochondrial biochemical pathways. It can disinhibit and increase
complex IV, whose inhibition correlates with Alzheimer's disease.
Methylene blue might also delay
senescence as one study has shown that it extended the lifespan of
IMR90 fibroblasts by more than 20 population doublings.
[41]These findings are highly controversial,
[citation needed] and a clear dosage response curve has not been found."
Apparently some take 60mg+
"The
University of Aberdeen held a
Phase IIB clinical trial[4][5] on 321 people with mild Alzheimer's disease in the
United Kingdom and
Singapore and found that taking the drug 3 times a day over a period of 50 weeks slows down the development of Alzheimer's disease by about 81%.
[6]The patients were split into four groups: one group taking a dose of 30 mg, another taking a dose of 60 mg, a third taking a dose of 100 mg and the fourth taking a
placebo. The 60 mg dosage gave the best results, giving an 81% reduction in mental degression compared to those on the placebo. Only those on the placebo experienced a decline in mental function."
In a 2% soultion 1ml should equal 1g of
Methylrosaniline hydrochloride (please confirm that this is MB and not New MB which is toxic). So a full 1l bottle with 1.5ml MB would result in a solution containining about 1.5g of methylene blue = 1500mg. And since only 1.25ml of this solution is used, that equals about 1.875mg (3.6 if 500ml bottle is used) of Methylene Blue according to my calculations.
Considering that they used 60+mg per day to treat certain brain conditions wouldn't you agree that ~2 mg (4mg for 500ml bottle) is rather ineffective ?
Edited by Tatsumaru, 07 October 2012 - 11:31 AM.