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The Anhedonia Thread

anhedonia depression attention l-dopa ssre adaptogen quetiapine consummatory anhedonia

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#391 PeaceAndProsperity

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Posted 29 May 2017 - 12:50 AM

The 5ht2a receptor causes a whole host of symptoms in psychotic disorders. Flat affect is the worst, before flat affect is blunted affect and similar things. Are you sure you're flat and not just the less severe versions?

 

I've found Ginkgo Biloba to be effective against the fatigue and emotional blunting (doesn't fully resolve though it works well) but sadly Ginkgo Biloba is notorious for causing anxiety. I believe it is a 5ht2a antagonist.



#392 Hip

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Posted 29 May 2017 - 01:02 AM

I think I am more blunted affect these days (some emotions sometimes appear), though I was probably closer to flat affect (no emotions) a few years ago, when my symptoms were more severe. 

 

I found this page by SelfHacked on some of the effects of 5HT2A. 



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#393 medievil

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Posted 05 January 2018 - 01:29 PM

Bump


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#394 Galaxyshock

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Posted 06 January 2018 - 08:29 AM

Yeah what's new in anhedonia treatments?

 

Aripiprazole relieves motivational anhedonia in rats.

https://www.ncbi.nlm...pubmed/29100151

 

Just a rat study but overall Aripiprazole is considered activating unlike all other APs. I took Aripiprazole for a while and did notice the activating effect. Unfortunately it seemed to make me unable to stay still and a bit restless so I decided to stop taking it. I also experimented with Scopolamine, an anti-muscarinic, which seemed to have some hedonia-enhancing qualities but the side effects of disorientation and cognitive decline weren't worth it.

 

Kava is pretty nice herbal with recreational effects. It's good for social anhedonia, makes you want to chat people and be genuinely interested in their lives. Also makes music sound better. Only problem is the horrible taste and having to ingest quite a lot of the plant matter if you want the strong effects. Last time I took it I vomited so I'm now a bit aversive about using it.

 

Right now I'm taking a lot of botanicals with surprisingly strong effects in all areas of anhedonia. I'll post more when I can make more objective conclusions.


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#395 Vieno

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Posted 12 January 2018 - 11:02 AM

I am still alive


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#396 Stinkorninjor

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Posted 12 January 2018 - 02:11 PM

Yeah what's new in anhedonia treatments?

 

Aripiprazole relieves motivational anhedonia in rats.

https://www.ncbi.nlm...pubmed/29100151

 

Just a rat study but overall Aripiprazole is considered activating unlike all other APs. I took Aripiprazole for a while and did notice the activating effect. Unfortunately it seemed to make me unable to stay still and a bit restless so I decided to stop taking it. I also experimented with Scopolamine, an anti-muscarinic, which seemed to have some hedonia-enhancing qualities but the side effects of disorientation and cognitive decline weren't worth it.

 

Kava is pretty nice herbal with recreational effects. It's good for social anhedonia, makes you want to chat people and be genuinely interested in their lives. Also makes music sound better. Only problem is the horrible taste and having to ingest quite a lot of the plant matter if you want the strong effects. Last time I took it I vomited so I'm now a bit aversive about using it.

 

Right now I'm taking a lot of botanicals with surprisingly strong effects in all areas of anhedonia. I'll post more when I can make more objective conclusions.

 

Since the activating properties probably come from the partial D2 and D3 (in particular) effects, then it might be a good idea to try some of the LESS activating partial agonist AP's* - there is now also Cariprazine and BREXpiprazole in particular - they are both less prone towards causing the same kind of akathisia Aripiprazole does.

 

Brex is probably your best bet, since that's the drug that has actual testing for the treatment of depression under its belt - showing efficacy! And it's the most similar to Aripiprazole, without being as jittery... With that said, the side-effects of weight gain and increased prolactine is then back - but honestly? If it works, it's probably worth it - at least it would be to me.

 

 

*(I'm not sure if calling these "AP's" is the right word though... SDAM's seems more accurate - the side-effects and effects are rather different, and the potential span of use is much wider than classic 1-2-gen AP's)



#397 magniloquentc0unt

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Posted 16 January 2018 - 04:09 PM

im supplementing ginkgo, maca and zinc regularly

probiotics too

that has worked pretty well recently to keep me in a good mood and cognitively on the positive side

i had tried microdoses of vortioxetine for a while and it works great for anhedonia (cognition especially, which i think its what impacts me the most from depression)

but i had penis issues after a while of regular dosing so i discontinued (albeit much less than normal SSRIs)

anhedonia wise i must say i believe im doing much better in recent months, but motivation and drive is still a big issue

i will try ladasten as soon as shops have it back in stock (apparently sold out all over the world wide web - go tell)



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#398 magniloquentc0unt

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Posted 16 January 2018 - 04:22 PM

besides that, the real and only "nuke" for anhedonia ive ever found was NSI-189, but it was extreme and most of the time not on the positive side. it was a negative situation which i, due to the nsi, blew out of proportions. 

to be honest i had lost all my addictive behaviours in that period, which was great. no compulsive porn/masturbation/videogames use (on a side note if anyone has a trick on how to get rid of that...welcome! its super bad for anhedonia i know...)


Edited by magniloquentc0unt, 16 January 2018 - 04:27 PM.






Also tagged with one or more of these keywords: anhedonia, depression, attention, l-dopa, ssre, adaptogen, quetiapine, consummatory anhedonia

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