http://www.ncbi.nlm....pubmed/19796046
as well as another study i posted in the Epitalon thread.....Maybe just higher dosage is what is needed
Posted 14 November 2012 - 05:52 AM
Posted 14 November 2012 - 06:22 AM
Posted 14 November 2012 - 07:51 AM
Posted 14 November 2012 - 09:25 AM
Posted 14 November 2012 - 12:52 PM
melatonin-treated (10 mg/kg melatonin, i.p. for 21 days)
Posted 14 November 2012 - 10:00 PM
From the paper bocor posted:
melatonin-treated (10 mg/kg melatonin, i.p. for 21 days)
If Paul Wakfer's going by this, then he must weigh three kg. If you metabolically scale the dose by the usual rat/human factor, then he'd be a portly 18kg. Even though he's on CR, he's still not hitting the dose in the paper. I wish they had done a dose-response experiment, so we could see if a human-feasible dose would have worked. On the other hand, melatonin is a funny compound- a lot of people have noticed that non-physiological doses are not as sleep-inducing as sub-milligram doses. What happens when a human takes a hundred milligrams of melatonin, anyway?
Posted 03 July 2013 - 07:41 AM
From the paper bocor posted:
melatonin-treated (10 mg/kg melatonin, i.p. for 21 days)
If Paul Wakfer's going by this, then he must weigh three kg. If you metabolically scale the dose by the usual rat/human factor, then he'd be a portly 18kg. Even though he's on CR, he's still not hitting the dose in the paper. I wish they had done a dose-response experiment, so we could see if a human-feasible dose would have worked. On the other hand, melatonin is a funny compound- a lot of people have noticed that non-physiological doses are not as sleep-inducing as sub-milligram doses.
What happens when a human takes a hundred milligrams of melatonin, anyway?
Edited by blood, 03 July 2013 - 07:57 AM.
Posted 03 July 2013 - 07:56 AM
http://www.medical-hypotheses.com/article/S0306-9877(10)00340-3/abstract
Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity
Reza Rastmanesh
Faculty of Nutrition and Food Sciences, Dept. of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
Received 29 May 2010; accepted 7 August 2010. published online 30 September 2010.
Abstract
Melatonin may play a causal role in the occurrence of age-related macular degeneration (AMD). Replicative capacity and response to injury in the retinal pigment epithelium (RPE) is compromised during aging. Prevention of telomere shortening by antioxidants may be a useful approach for reducing the cumulative effects of oxidative stress in RPE cells. Melatonin, a well known antioxidant, which acts advantageously as an amphiphilic agent, may benefit AMD patients more than commonly used lipophilic or hydrophilic antioxidants. It also may act through mechanisms other than antioxidant mechanisms because melatonin has receptors localized in the RPE, which act locally as a neurohormone and/or neuromodulator. Results of a clinical trial showed that 3mg melatonin given orally each night at bedtime for 3months to AMD patients reduced pathologic macular changes. I hypothesize that melatonin exerts additional benefit through down-regulating hTERT (catalytic subunit if telomerase) expression and stimulated telomerase activity in RPE, which subsequently helps to prevent or treat AMD. I suggest that melatonin therapy as pharmacologic agents and/or melatonin-rich foods, especially in AMD patients with measured low serum melatonin levels or high risk patients would be possibly an alternative approach to prevent and/or treat AMD. I suggest that melatonin has potential to prevent telomere shortening in RPE, while not precluding other mechanisms, namely antioxidative properties and/or restoration of inner blood-retina barrier (iBRB) integrity, reduced vascular endothelial growth factor (VEGF) and nitric oxide (NO) levels as well as leakage of horseradish peroxidase (HRP), inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha) stabilization under hypoxia.
Posted 17 January 2017 - 12:26 AM
Bump. I think I will test this (especially for eye sight) in an elderly relative of mine.
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