3 replies to this topic

[NZT48_User]

I'm looking for a nootropic stack that beats everything ever conceived. To do this, it has to have the following criteria:
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Non-stimulant - if your jittering off your seat and on the edge of getting a heart attack/stroke, any cognitive enhancment it might bring is worthless.


Safe - it must be ok to take for short and long-term.


Relatively low cost and effective


Smart - Most people want to know how it works. Ex: Aspirin acts via COX inhibition, in effect, attenuating inflammation.

Outside the box - magnesium and fish oil is not thinking outside the box. Everyone is sick to death of hearing about supplements like that.


Non-redundant - taking all the racetams (pir, oxi, ani, pram) is an example of being redundant because they all basically have the same mechanisms of action.


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I've been working on my stack for ages. Here's what I've come up with, including a brief summary about the ingredients:



Pramiracetam - agonizes muscarinic receptors

Nicotine - agonizes nicotinic receptors - enhances working memory

Bacopa - myosin enhancement - increases long-term memory

Agmatine - agonist for alpha-2 adrenergic receptor - increases working memory



This stack is concentrated at improving memory, short and long-term.
All these supplements have been proven in studies to significantly improve memory, among other cognitive functions.
They all have several mechanisms of actions on the brain, but I listed the ones I think are the most relevant.


I listed "myosin enhancement" as Bacopa's mechanisms of action. I have not directly confirmed this in studies, but it works on myosin indirectly.
Many people don't know that myosin is a major regulator in memory formation.


http://www.scripps.e...0/rumbaugh.html


Bacopa increases many factors that positively influence myosin activation. This is one of my own theories.

Questions, comments, suggestions?

[NZT48_User]

I'm gonna add more criteria for creating a stack:

Long half-life: who wants to swallow pills every 30 minutes? Once with every meal should be the absolute limit.
Fat-soluble: To get into the brain(through the blood-brain barrier), it should be fat-soluble.

So, using these additional rules, I'm gonna replace Agmatine with Pterostilbene, since Agmatine has an extremely short half-life(5.5 minutes) and it's not fat-soluble. Pterostilbene, a derivative of Resveratrol, is fat soluble and has a long half-life(105 minutes) relative to Resveratrol(14 minutes). It's shown in studies to be a potent antioxidant and increases working memory. When I take large amounts of Pterostilbene, I turn into a machine. No jitters. I'm completely consumed by whatever I'm supposed to concentrate on, not thinking about food, drugs, or girls. I can multi-task like a pro, and my short-term memory feels seamless. I've tried almost all nootropic supplements, and Pterostilbene is on the top of my favorited list.

[LBGSHI]

Fat-soluble: To get into the brain(through the blood-brain barrier), it should be fat-soluble.

Fat-solubility shouldn't be a requirement. There are many water-soluble supplements that still effect the brain, either directly or indirectly, with positive effects. Personally, I find oxiracetam to be highly effective, and it's water-soluble.

On other points, I agree.

Perhaps you could list the supplements you've tried, and your general experience with each...then we'd save time by not suggesting things you've already tried, and by understanding more accurately what it is you hope to achieve, and what it is you hope to avoid (aside from your general mention of memory enhancement being desirable).

[NZT48_User]

Correct, water-soluble substances can pass the BBB. But I was under the impression that fat-soluble is more potent. I've tried pretty much all nootropics that are legal. I'm uncomfortable with illegal nootropics. The only drugs that I've had significant experiences with are the ones I've listed besides Agmatine. Nicotine, Pramiracetam, Bacopa, and Pterostilbene is my current stack. Personal experience is good, but people must also remember the placebo effect. In my opinion, true cognitive enhancement should be seamless. If you feel "high" or "stimulated", you should go back to the drawing board.

Personal experience with my stack:

Nicotine - Increased focus and working memory.
Pterostilbene - Same experience as the Nicotine, but more powerful. (Although I always take very small amounts of nicotine to avoid side effects)
Bacopa - Increased confidence and long-term memory. Though I think this might a placebo effect.
Pramiracetam - At first I felt as though my emotions were inhibited, then later realized that I actually had an increased amount of control on my emotions. I also felt like all the junk was emptied out of my mind.