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Aniracetam and methylphenidate

nootropic stimulant

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#1 ocean.soul

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Posted 05 January 2013 - 08:23 PM


I have been searching the web (specially longecity) for an explanation other than an experience* if methylphenidate and aniracetam can be taken together, without results. Can anybody speculate, at least, if this two drugs can be taken together??
I am a little skeptic because many people say that aniracetam exerts as an anxiolytic but mehtylphenidate is a stimulant, so isnt this sort of a contradiction??

* Is not that I don't appreciate their experience but many people are taking a lot of thing at the same time.

#2 Jonathan Moy de Vitry

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Posted 07 January 2013 - 11:20 PM

I have been searching the web (specially longecity) for an explanation other than an experience* if methylphenidate and aniracetam can be taken together, without results. Can anybody speculate, at least, if this two drugs can be taken together??
I am a little skeptic because many people say that aniracetam exerts as an anxiolytic but mehtylphenidate is a stimulant, so isnt this sort of a contradiction??

* Is not that I don't appreciate their experience but many people are taking a lot of thing at the same time.




Hi there!

Sorry to answer your question with a description of my *experience*. Hope that it will still be informative to you.

I have been on Ritalin 10mg x 2.5 daily for the last 7 years or so as a treatment for my really severe ADHD P.I. It helped me quite a bit but it always felt like a rather crude and incomplete tool. On one hand it subdued my depression, helped with the lethargy, and improved my short-term memory, on the other it felt like it overstimulated me to the point that my cognitive abilities were hindered.

This year, because of a master's program that was pushing me to the limits of my abilities, I began searching for alternative pharmaceutical treatments for my condition. Nootropics seemed promising, so I began testing a few, one at a time. Noopept, sulbultiamine, choline, then aniracetam. When I got to aniracetam, I knew I had found something special.

That first day, about a week ago, I took 700mg with my morning Ritalin and within 10 minutes I began to feel the strangest sensation of awakeness I've ever felt in my life. What a feeling! I was awake yet strangely unstimulated or euphoric. After all those years of being jolted by the dirty feeling Ritalin every morning, this was refreshingly subtle. In fact, I would say that the aniracetam "cleaned up" the feverish zippiness of the Ritalin.

At that point I realized that aniracetam was a potentially life-changing compound, so I put together an excel log to write down personal observations of my behavior, dosages, and a few other variables. My reasoning was that I should be scientific in determining the right dosage of this powerful aid and the only way to do that is through methodical documentations of my experiences with it. I hope to share this data in a month or so, once I've optimized it to really cover the important mental performance indicators.

Anyway, I've been playing with my aniracetam dosages while keeping my Ritalin intake rather constant. At 1500mg(morning), 800mg(afternoon),500mg(evening) it really seems to take the speedy, almost anxious feeling I usually get with Ritalin. Instead, I feel focused, alert, creative, and social in ways I never felt before. I don't know if this level of positive effects will continue indefinitely, but I can guarantee you they're not a placebo and that they feel like an excellent complement to a Ritalin regimen.

Sorry for the shilling ;) As I said, I'll try and provide some more hard data once I've collected enough of it to be worthwhile.
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#3 ocean.soul

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Posted 08 January 2013 - 03:55 PM

It's ok. I do appreciate experiences! Sometimes I find difficult to see the relevance of experiences about a particular group of drugs when in fact the subject is taking them among others.
But what you told me is similar to what I want it! So, thanks you!

I will also log my experience, since today I started with 750mg of aniracetam.

#4 tau_ceti

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Posted 10 January 2013 - 01:02 AM

So how did it go for you?

#5 magniloquentc0unt

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Posted 19 January 2013 - 06:48 PM

this is very relevant to my interests.
do you think ritalin + piracetam is a good idea?
id like to try next week

Edited by magniloquentcunt, 19 January 2013 - 06:49 PM.


#6 Acetylnordopatoninol

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Posted 19 January 2013 - 10:19 PM

I have both of these but never combined them since I'm wary of excitotoxicity. Does anyone know if that's something to be concerned of in this case?

#7 brainslugged

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Posted 18 March 2013 - 04:01 PM

MPD is not neurotoxic. It is actually neuroprotective, so I don't think there is much to worry about. Even sustained cocaine use (which is similar in mode of action) does not have major neurotoxic effects.

#8 8bitmore

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Posted 18 March 2013 - 05:01 PM

MPD is not neurotoxic. It is actually neuroprotective, so I don't think there is much to worry about. Even sustained cocaine use (which is similar in mode of action) does not have major neurotoxic effects.


While cocaine can protect dopamine neurons it is hardly overall neuroprotective and also, what worth is your neurons is if this is what happens to your body:

"Cocaine may also greatly increase this risk of developing rare autoimmune or connective tissue diseases such as lupus, Goodpasture's disease, vasculitis, glomerulonephritis, Stevens–Johnson syndrome and other diseases.[1][2][3][4] It can also cause a wide array of kidney diseases and renal failure.[5][6]

Cocaine misuse doubles both the risks of hemorrhagic and ischemic strokes,[7] as well as increases the risk of other infarctions, such as myocardial infarction.[8]"


All from: http://en.wikipedia.org/wiki/Cocaine

However, that being said the neuroprotective aspects of cocaine may be mirrored in coca leaf tea which have excellent safety profile despite extremely wide spread use in South America, the only problem is how to import due to all the excessive safety regulations put in place to try and stop cocaine itself.

#9 jadamgo

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Posted 21 March 2013 - 01:54 AM

In my extensive experience with using both methylphenidate and aniracetam, the two do not have any significant interactions. Each one works independently of the other.

#10 therein

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Posted 09 October 2013 - 07:42 PM

I am aware that this is an old thread but I would like to bring this to people's attention once again since I am very satisfied with this combination.

I am diagnosed with ADHD and have tried Ritalin, Vyvanse, Adderall, Focalin and even Desoxyn. I am currently taking 4 x 5mg Focalin (Dexmethylphenidate) with 2 x 500mg Aniracetam combined with Phosphatidylserine (comes with EHA/DHA, so it helps with the Aniracetam absorption).

I also know that I have social anxiety. This combination has been a great remedy to both. It makes me more sociable, gives me great motivation and increases my verbal fluency. I have been very happy with this combination and I have been using it for the last three months.
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#11 NootPoint

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Posted 10 November 2013 - 11:09 AM

I can't believe I didn't find this post earlier, in all my millions of modafinal hours spent researching this question, and questions tangentially related to it.

I've wanted to make my foray into the fascinating world of nootropics for a while, partly due to my experiences with Ritalin LA, Methyln ER, Concerta, and straight-up methylphenidate. I mean that in two ways: 1)Taking Ritalin and experiencing focus, concentration, and much better than my usual subpar levels of motivation and recall, it was like a veil was lifted. I wondered how I had ever managed without it, rememberig in painful detail how I struggled in school - most noticeably during my first stint as an undergraduate, when I cared about my studies, was challenged by them, and couldn't coast through with my brain offline as I had in high school - and at what cost I managed to finish, to get that diploma. Endless nights of frustration and desperation, throwing my textbooks across the room after realizing that while I thought I had been studying intently for hours, nothing had stuck. I would read the same lines over and over and over, for a long time before even realizing it (when I did I hung my head, crying, wondering what on earth was wrong with me). Spacin out during midterms and finals only to "come-to" and see that time was almost up and I hadn't yet done much of the exam at all. The second time I webt to school, about halfway through, my doc decided to try Ritalin, to my surprise. And all of a sudden, I could read-- and understand what I was reading. And remember it. I could pay attention in class, even during my late-night 4-5 hour seminars, or early Saturday morning meetings. "Is this what normal people feel like?" I wondered. So I guess that was all a long-winded way of saying that Ritalin made me aware of how much more my brain was capable of...which created a far greater hunger in me, which ultimately led me to brain training, overhauling my diet, and devouring all the research and anecdotal evidence I could find on anything even vaguely related...thus my all-consuming interest in nootropics, and impatience to get off enough of the psychotropics (which I take mostly for bipolar disorder, anxiety, and some neuropathy/chronic pain issues, a process I've been undergoing for about two years now. From literally more than 10 different medications each day, I am down to less than five, and in remarkably low doses. But alas, I've still got a ways to go yet). So Ritalin first made me wonder how much further I could take my brain's supposed "limits". But 2)It also, while remainig the single most effective medication in my "cocktail," still doesn't feel quite right, somehow. It does what it's supposed to, and for that, I'm grateful, but I'm not entirely comfortable with it. You're right, it feels "dirty." It works, maye too well. I know when I'm on it that I'm on it. It's synthetic-feeling. And the healthier I get, the more probounced this is. And more and more, I get the feeling that somethig crucial is lacking, like I'm missing a key to...gettig it right.

I haven't ventured very far into noot-land, afraid as I am of interactions with the psychotripics I take. (I take Cymbalta, Abilify, Topamax, and Methylphenidate). I have, however, been working hard on my being consistent with dietary considerations, regular exercise, getting sufficient, quality sleep, and beig religious about taking my multi, B-Complex, Fish Oil, and Vitamin D. I added Bacopa a few days ago as well, after deeming it safe enough to at least try out (and worth it). And...I was given a jar of Liftmode's highly-touted Phenylpiracetam, so I experimented with that for three weeks. Differnt doses, at different intervals, but not daily, ever. I had none of the dramatic, life-changing effects so many others report, nor any of the subtler ones. However, during my experiment, I happened to run out of all my medications for several days, and when I tried the pp after having been off all that stuff, while I was neither superhuman nor super-verbal, I could definitely tell that it was workig on my brain. I felt like my brain just liked it. Like my brain was ever slightly more stable, solid, and working better despite not being able to subjectively discern any effects to prove this. So we'll see. I have a long way to go yet in reducing the meds, but I think there may come a day in which it might benefit me.

I admit, this was a little frustrating, after all I'd read about its purported efficacy. It may have been frustration which led to my decision to try Modafinil. That, beyond any shadow of a doubt, makes my brain happy. Again, not superhuman, just not stuck in bed or spacex out all the time. Just, y'know, verging on functional, almost. ;)

So there has been definite, clear progress, and there's reason to hope for more. Yet...

Something's still missing. Researched possible potentiators of methylphenidate. (L-Tyrosine? That'd make sense, and be convenient, since thst has worked quite well for me in the past. Magnesium taurate? Same thing). At this point, I don't know whether to take the Modafinil or the Ritalin, or smaller doses of both, together. If I stick with the Ritalin, do I begin to i corporate L-Tyrosine, and bring the magnesium taurate back (why DID I stop taking it?) I have L-Theanine coming, to take with my morning coffee, and in the evenings to relax. That seems like it would work for Ritalin the way it is reported to for caffeine, namely in reducing jitters/anxiety (I get horrible anxiety and stopped takig all benzos 9 months ago, haven't really found a way to control it yet). Alpha-GPC is also in that order, just to have available. And...so is Aniracetam. I could NOT shake the feeling that I was lacking an essential component of this "stack," and wondered about ani's effects on creativity and on reducing anxiety. (Creative enhancement is a particularly inteiguiguing prospect, as I am poet and painter). Given all this, it seemed to make so much sense. I don't intend to start L-Tyrosine, L-Theanine, Alpha-GPC, Aniracetam, bring back Magnesium Taurate after long time off, waver between Ritalin an Modafinil, still taking all these psych meds, all at once. But after stumbling across this thread, I feel encouraged, that I'm on the right track. This theead has articulated and validated much for me; thank you.

And I realize this was an Homeric-length post, (I apologize, I'm having a hard time with my brain's filter/edit function right now...) but if anyone HAS managed to read through it all, first accept my thanks. And the , please, if you have any advice, tips, suggestions, experiences to share, I'm grateful for any help.

I'm so glad I found this forum. Thanks, everyone.

#12 xks201

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Posted 10 November 2013 - 02:47 PM

Why are you on abilify? That drug antagonizes tons of neurotransmitter receptors according to wikipedia. I would guess that that would be quite an anti nootropic drug. You are blocking neurotransmitters and transporters with that drug and increasing them with cymbalta and ritalin. It makes no sense to me.

Ritalin gives me anxiety. It is a roller coaster ride imo.

#13 therein

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Posted 10 November 2013 - 10:38 PM

@xks201
You should give Focalin a chance, or maybe try Ritalin at lower dosages. Abilify works on GABA, which is an inhibitory neurotransmitter. I heard it does a good job reducing anxiety, which might improve motivation, efficacy and concentration.

@NootPoint
Sounds like we are in similar situations. I am prescribed Focalin (Dexmethylphenidate), tried Ritalin, Vyvanse and Adderall before. These definitely improve my quality of life. I lack motivation and these help immensely. I tried Modafinil too, but it just exacerbated my social anxiety.

Let me know if you figure out the missing piece.

Edited by therein, 10 November 2013 - 10:38 PM.


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#14 NootPoint

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Posted 11 November 2013 - 04:33 AM

@xks201
I take Abilify as part of my bipolar treatment, to cap off/prevent the manias that have caused untellable pain and destruction in my life, to augment the Cymbalta and enhance its efficacy. I'm certain it's part of the reason my anxiety is not totally crippling me, as it once did. I took benzos (mostly klonopin) for thirteen years (I'm only 31), and have tried everything else out there in the realm of anti-anxiety, anti-depressants, anti-manic agents, antipsychotics of all types, sedatives, tranquilizers, mood stabilizers, (and epilepsy meds for this purpose). Small doses of Cymbalta with small dosez of Abilify have been the only relief I've found from the prision of "Bipolar I, rapid cycling, mixed, with psychotic features," kept me from having to be hospitalized again, and basically keep me alive. And so, anti-nootropic or not, the way I see it, one cannot even theoretically consider ways of maximizing brain capacity, and certainly not concerns of longevity, without first finding a way to stay alive. With a ruthless illness such as I have, which has very nearly killed me a few times, I have to deal with he fundamental issue of simply staying alive before anythig else. And Abilify is an integral part of that. I am only looking at nooots now that I have the stability and wherewithal to do so. I's prefer not taking these meds, but I prefer life more, so there it is. But within these limitations, I still seek to do all I can to achieve maximum health, and to be able to not only survive, but *live*-- live well. My goal is to thrive, and live a life of meaning, even with the constraints placed upon me by my conditions, and having to take medication for them. (Supporting overall brain health, finding ways of minimizing neurotoxic damage from the meds is another motivation for me here). Also, I used to find Ritalin a roller-coaster ride too, and would actually be taking Ritalin LA, since I never really noticed when it kicked in and never really crashed on it, but none of the pharmacies here (I live on an island) ever carry it. So I've just learned to be extra-diligent in spacing out consistent, small doses, Nd haven't had problems anymore.

Since you asked. ;)

@therin
I will definitely let you know if I find that missing piece. I'm most hopeful about magnesium (taurate), and about combining aniracetam with Ritalin. I plan to try L-Tyrosine again, to see if it helps potentiate the Ritalin, or boost it, or something. But mostly, I want to see if the ani/ritalin mix helps keep he focus, memory, motivation, productivity, but with more creativity involved. I feel sometimes like a productive machine, and writing and painting have been nearly impossible for me. But at least I'm not bedridden all the time anymore, and can handle going out, seeing people, doing things..like basic chores. :) I'll let you know what, if anything, works out for me.





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