BMJ Case Rep. 2012 Oct 12;2012. pii: bcr2012007180. doi: 10.1136/bcr-2012-007180.
Unexpected remission of hepatocellular carcinoma (HCC) with lung metastasis to the combination therapy of thalidomide and cyproheptadine: report of two cases and a preliminary HCC cell line study.
Feng YM, Feng CW, Chen SC, Hsu CD.
Source
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Abstract
We reported two cases of hepatocellular carcinoma (HCC) with lung metastases who were treated with a combination of thalidomide andcyproheptadine. The use of cyproheptadine in these two cases was originally for skin itching. Follow-up CT images revealed a complete remission of HCC in both of them after treatment for 6 months and 6 weeks, respectively. A following experimental cell line study demonstrated thatcyproheptadine effectively reduced the viability of two HCC cell lines.
I urge everyone that sees abstracts like this to post them, you never know when they come in handy with a 1/3th rate of the population...
