4019 replies to this topic

[mettmett]

Bpc-157 and tb-500 both can be taken orally. However for quicker injury recovery, the consensus is to dose SubQ closest to the area that is injured.

It does work systemically.

[lourdaud]

I've been discussing i-insulin with a number of people over at healthrising.org lately and a member over there named Hip (props to him!) came up with a list of possible sources for i-insulin for those who don't live in the US and Canada.  http://www.healthris...l-insulin.4820/

 

I have never ordered from any of these places so I can't confirm their quality but I figured I'd share anyway just in case anyone wants to give it a go (I think some of these places may require a prescription). I'd recommend trying Humulin R or Actrapid to start with. 

 

http://www.roidsseek...r</b>-4199.html

http://www.roidsseek...n-nph-8178.html

http://www.neomeds.c...r</b>-3801.html
http://www.neomeds.c...-3-ml-6065.html
http://www.neomeds.c...40-iu-5145.html

https://www.anabol-s...umalog-insulin/
https://www.anabol-s...</b>-eli-lilly/

http://alvgear.com/humulin-r
http://steelgear.net...nsuline-steroid
http://www.originals...n-r</b>-26.html
http://roidspot.net/...&product_id=115

http://onlineshoppha...&product_id=107
https://www.buckaday...cy.com/Novolog/
https://www.buckaday...cy.com/Humalog/

http://www.buypharma...ion-p-2486.html
http://www.buypharma...dge-p-1019.html
http://www.buypharma...ion-p-2470.html

 

Has anyone found a reliable source that offers shipping to Europe (Sweden)?
Steelgear does but they're expensive, anabol-steroids as well but they seem shady and require a 150 USD minimum order.
 

[sentics]

i haven't ordered there (yet), but from what i can see, they do deliver to european countries 

 

http://www.roidsseek.com/

[Q did it!]

So guys saw my psychiatrist today and that went over terribly!
She thinks I will fry my brain uning i-insulin or i will kill myself and she won't look at the data saying its not approved by the fda. Which is a story in its self... And in order to keep her as my doctor I gotta stay off the "crap". Though since I have been on it my mood has stabilized significantly and no panic or anxzity its amazing plus its only been a week. But I have been using tulip and meditation on top of i-insulin so its definitely the combination. Oddly enough she is OK withe using lasers/LED's or at least that was a year ago.
I start school in the spring and its one of the reasons I choose this biohack i-insulin. She wants me to stay away from all biohacks. Saying its bad behavior and thinking plus saying I have problems with my thinking!
Sorry if this is all irelivent to the discussion. But it sort of ends my testing with i-insulin till I don't have a guardian, move out of state (live in Missouri atm ) probably to Arizona or Colorado but that won't be for one to two years. And I was all hyped about getting back into this community!
I will be using the 20/10 study method this spring so not all is lost.

[Groundhog Day]

Found an interesting comment on that Bob Greenfield blog on BPC 157 that might also be relevant to I-Insulin and it's longevity.

 

Devin Wallace writes:

 

I’d like to clear up ALOT of bad information given here Ben. First off your BUD (Beyond Use Date) is WAY OFF! if you were preparing this in a sterile environment aka ISO-5 clean room these dates would be acceptable. But in you home the expiration would be 4 hours to 7 days max with some good aseptic technique and clean room material.

If you prepare this drug in a non sterile environment you are putting yourself at risk of infection, serious diseases and potential death. Dont believe me…we have compounding pharmacies close every year for less than sterile compounding that kills and injures hundreds of people. New England Compounding Pharmacy ring a bell?

You should not be using Bacterio-static water but SWFI. I’d HIGHLY advise putting the product in a new ziplock plastic bag after reconstitution and putting it in the fridge. Because moldy food spores on the rubber stopper of the vial.. no bueno. Sterilize the rubber stopper EVERY time you use it.

Read more http://bengreenfield...to-use-bpc-157/

[lostfalco]

 

Found an interesting comment on that Bob Greenfield blog on BPC 157 that might also be relevant to I-Insulin and it's longevity.

 

I definitely agree that we should be cautious and attempt to be as sterile as possible...but things are a bit safer with the intranasal route. =)

 

"IN drug administration presents remarkable advantages: it is painless, non-invasive, easy, and does not require sterile preparation [74]. In addition, it allows BBB bypass, systemic absorption reduction, and a decrease in first-pass metabolism, reducing potential side effects [75]." https://www.ncbi.nlm...les/PMC4861046/

 

 

 https://www.ncbi.nlm...les/PMC4861046/

 

Transl Stroke Res. Author manuscript; available in PMC 2016 Aug 1.

 

Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke

Vasileios-Arsenios Lioutas,1 Freddy Alfaro-Martinez,1 Francisco Bedoya,1 Chen-Chih Chung,1,2 Daniela A. Pimentel,1and  Vera Novak1

Author information ► Copyright and License information ►

 

Abstract

Treatment options for stroke remain limited. Neuroprotective therapies, in particular, have invariably failed to yield the expected benefit in stroke patients, despite robust theoretical and mechanistic background and promising animal data. Insulin and insulin-like growth factor 1 (IGF-1) play a pivotal role in critical brain functions, such as energy homeostasis, neuronal growth, and differentiation. They may exhibit neuroprotective properties in acute ischemic stroke based upon their vasodilatory, anti-inflammatory and antithrombotic effects, as well as improvements of functional connectivity, neuronal metabolism, neurotransmitter regulation, and remyelination. Intranasally administered insulin has demonstrated a benefit for prevention of cognitive decline in older people, and IGF-1 has shown potential benefit to improve functional outcomes in animal models of acute ischemic stroke. The intranasal route presents a feasible, tolerable, safe, and particularly effective administration route, bypassing the blood–brain barrier and maximizing distribution to the central nervous system (CNS), without the disadvantages of systemic side effects and first-pass metabolism. This review summarizes the neuroprotective potential of intranasally administered insulin and IGF-1 in stroke patients. We present the theoretical background and pathophysiologic mechanisms, animal and human studies of intranasal insulin and IGF-1, and the safety and feasibility of intranasal route for medication administration to the CNS.

 

Edited by lostfalco, 28 September 2016 - 03:47 AM.

[lostfalco]

Would BPC-157 be best administered locally at the site of the injury or does it work systemically in the body?

Mettmett hit the nail on the head. It works both ways but if you have an injury it's not a bad idea to administer at that location. 

[lostfalco]

Ohh my, I'm quite embarrassed. Sorry for that large waste in time. 

 

How is your Agomelatine use going?
 

No problem, Bluecheer. =)

 

Currently taking a break from Agomelatine to test out BPC. Initial impressions are very good. Seems to noticeably improve recall for me. Not sure about acquisition yet but I'll be testing it more in the coming days. Doesn't feel like a stimulant at all and no mood effects noticed yet. Still have a lot more experimenting to do.  

[lostfalco]

So guys saw my psychiatrist today and that went over terribly!
She thinks I will fry my brain uning i-insulin or i will kill myself and she won't look at the data saying its not approved by the fda. Which is a story in its self... And in order to keep her as my doctor I gotta stay off the "crap". Though since I have been on it my mood has stabilized significantly and no panic or anxzity its amazing plus its only been a week. But I have been using tulip and meditation on top of i-insulin so its definitely the combination. Oddly enough she is OK withe using lasers/LED's or at least that was a year ago.
I start school in the spring and its one of the reasons I choose this biohack i-insulin. She wants me to stay away from all biohacks. Saying its bad behavior and thinking plus saying I have problems with my thinking!
Sorry if this is all irelivent to the discussion. But it sort of ends my testing with i-insulin till I don't have a guardian, move out of state (live in Missouri atm ) probably to Arizona or Colorado but that won't be for one to two years. And I was all hyped about getting back into this community!
I will be using the 20/10 study method this spring so not all is lost.

Damn Q, that kinda sucks. Totally expected initial response from a psychiatrist although I am kinda surprised she won't even look at the data. 

 

Anyway, it's not a terrible idea to be cautious since you've recently made such great strides. You were already doing pretty well before you tried i-insulin, right?

[Q did it!]

Lostfalco,

I was doing pretty fine like an 8 of 10 but with i-insulin I am almost at a 10 minus the fatigue from my medications. But yeah it helped quite a bit! Just hope the effects will last. Definitely don't want to go back to the maddening states I have seen. I will keep using the LEDs for now and the insulin should keep for a while. How long, and its probably already been mentioned, should I store it in my refrigerator just to be safe?

[lostfalco]

Lostfalco,

I was doing pretty fine like an 8 of 10 but with i-insulin I am almost at a 10 minus the fatigue from my medications. But yeah it helped quite a bit! Just hope the effects will last. Definitely don't want to go back to the maddening states I have seen. I will keep using the LEDs for now and the insulin should keep for a while. How long, and its probably already been mentioned, should I store it in my refrigerator just to be safe?

Glad it's working so well for you Q! The effects have lasted really well for me. Yeah, I recommend storing it in the fridge. 

[normalizing]

i had to quit the insulin. in combination with several other meds and herbs or whatever, it gave me seizures. im not sure it did it by itself because when i originally brought it, i used it for few days with no positive results but neither negative so it was surprising it caused this but whatever was the key element i do not know, i just know this, i used it and just then i joined the epileptic's party.

i do remember tho i was also dosing high on bulletproof coffee and ibudilast as well prior to adding insulin, but it was going ok regardless that bulletproof coffee did cause me siezures once before when i mixed it with 300mg extra caffeine from various energy drinks but that was a long time ago and since then i quit caffeine for good and since i quit it, i havent had any similarity effect. so either insulin acts as caffeine replacement for me or it has similar action of some sort either way, dumped!

 

in other news, i was in europe and shopped true expensive pharmaceuticals from the source instead of buying those cheesy suspicious powders online. i got a dozen but i havent tried them all yet, just two.

 

i got the original agomelatine valdoxan quite expensive purchase i might add! hard to describe it yet, i only took it 2 days with some very strange effects. i assume its because i consumed beer both times (hard not to drink beer in europe) so it might have caused reactions, but they werent pretty! first of all, it felt exactly like melatonin for me, that same feeling of sleepiness and then same after effect of grogginess day after. except, valdoxan just made me very very strange next day feeling like a damn zombie! well, its a fucking antidepressant after all i shouldnt be surprised. 2 days dose, didnt like it at all my final thoughts BUT im open minded to experiment further as i spent too much on it (expect further experience)

 

second one i got was the absolutely original pharm based galantamine (nivalin). lots of dicussion on it here so thats why i mention it but to be honest i just took it few times, again, no real solid conclusion to it. the times i took it, i felt nothing. not sure what is the right dose? i took 2-3 pills of i believe the dose was 5mg? this stuff is expensive!!! there was no way i buy higher mgs. conclusion, still pending, same as agomelatine.

[Junk Master]

When you took galantamine did you ever take it without drinking?  If so, did you notice any unusually vivid dreams?

[normalizing]

i took galantamine during the day tho, not before going to sleep as i read reports you have to take it before sleep and right after you wake up and then go back to sleep again for those dreams to occur. but as i said, randomly i took it few times only so no real conclusion i just take too much shit and im being careful not to interfere for best results.

maybe its a personal thing or it happened to others who didnt report, but i had LSD dream visions on expensive wine before and right after my first awake and going back to sleep again. it happens every single time so its not placebo, in fact, its impossible to be placebo as its amazingly strong. BUT it usually takes megadoses. who in their right mind will megadose on expensive wine to get high on LSD like trip? nobody but me!  highly not recommended as thats toxic.

Edited by normalizing, 03 October 2016 - 10:34 PM.

[Junk Master]

LSD visions on expensive wine?  I could believe Absinthe, which I've never had the pleasure of drinking, but I've had my fill of Screaming Eagle Cab (not that I paid for it) and never had anything like LSD caliber dreams.  Now, I have had a few nights after drinking far too much Mescal where I've experienced vivid dreams before and after waking.   But still nothing like the dreams I had while taking galantamine.

 

To be fair, I do have sleep apnea, and my REM sleep can be disrupted for periods, then really vivid to the point of being exhausting when I do manage to be compliant with my CPAP machine and hit the right mix of nootropics/supplements.

 

For example, Modafinil definitely disrupts my sleep architecture, so if I manage not to need it for a few days I do find my REM sleep improved.  Also, I do think intranasal insulin has contributed to more REM sleep.

 

So maybe it was the combo of i Insulin and galantamine that did it?

 

Still haven't got my hands on any Ibudilast.

[normalizing]

i wanna resell my ibudilast it never worked out for me. it might have helped with concentration better but many things can do that too and i need more relaxation not excitation

[Basar]

hi Lostfalco, new on here i've been a long time follower of this thread. Thanks for all the great info ,

 

I've managed to get some insulin in the uk ordered from india  ,it is Lilly brand Huminsulin R 100iu,   i wanted to check how the ingredients compare to Novolin R before i spray any up my nose, it contains 10% hydrochloric acid and  10% sodium hydroxide solution,  m-cresol 2.5% and glycerine  i was little concerned about the first 2? but i guess its just the same as humulin r

 

if you think all is good i will report back after trying it for a few days.  Thanks

 

 

[normalizing]

junkmaster, i had to ask this, what dose galantamine you took and was it one of those internet powders or quality pills?

[Hyperflux]

BPC-157 has been nothing short of magical for me. It's such a versatile substance depending of RoA. How does InI and NASA (Semax) compare to it if anyone has experience? Thanks.

[Junk Master]

Mine was plain ol' Powder City.  Usually, I don't have any problem with the quality of their product, but just recently I purchased some micronized Creatine that usually has no taste and it tasted suspiciously bitter/acidic.  In fact, reminiscent of Phenibut...which, needless to say, would be a BAD switch.  I just tossed it.  It's tough to beat Powder City prices and fast shipping domestically.

[normalizing]

i agree powder city is good distributor i got good stuff cheap and fast BUT i had some experiences too with stranger than expected powders. it just comes to mind that no matter what, nobody is perfect, it doesnt mean they are always right on target with their stuff constantly consistently.

 

anyway, this is the one i got http://bizweb.dktcdn...v=1459394780440

 

im asking second time tho, how much is the needed dose as they come 5mg each?

[StabMe]

LF,

 

I am considering buying an oxygen concentrator. Do you find that there are lasting effect after a cycle of oxygen therapy? Or do effects only manifest themselves after a short term of administration?

[Groundhog Day]

I'm trying to get some BPC-157 but Peptide Warehouse seemingly only accepts Bitcoin... wtf?

[normalizing]

whats BPC-157? im behind on this one and wikipedia comes out empty...

[Werper]

Maybe try google........

[normalizing]

usually i enjoy letmegooglethatforyou

[farware]

That laser stuff is beyond me, don't really understand how it's supposed to work and the risks involved. PQQ/CoQ10 I can understand more easily - how long would this take for Mitochondria to adopt?  

 

Because someone mentioned it earlier - what do you think which substances (nonRX) comes closest to LSD?

 

 

[tronatula2]

Hi, I would like to try intranasal insulin. However, I react poorly to cholinergics (nicotine, cdp choline, fish oil, DMAE,...). Does intranasal insulin have cholinergic property?

[musicman4534]

Intranasal Insulin Discussion Question:

 

Should we be dosing intranasal insulin using rapid-acting insulin after meals to mimic a healthy body's insulin response? I'm wondering if the mechanisms 

 

 

Excerpts:

 

 

 

Emerging links between type 2 diabetes and Alzheimer’s disease

Gumpeny R Sridhar, Gumpeny Lakshmi, and  Gumpeny Nagamani

 

[on brain insulin...] In addition it also aids the release of β-amyloid peptide extracellularly, and increases the expression of the enzyme which degrades insulin, insulin degrading enzyme (IDE)[4]. As the latter also degrades β-amyloid peptide, insulin deficiency results in accumulation of β-amyloid peptide. Both hyperinsulinemia and hyperglycemia were shown to increase neuritic plaque formation[19].

 

[also speaking on brain insulin...] Whereas acute increases of insulin improve cognition, chronic hyperinsulinemia can adversely affect neuronal function in vitro by increasing susceptibility to toxin and stress-induced effects[31]. Glycated proteins and inflammatory mediators could also have a pathogenic role[25].

 

 

The above two excerpts from that study may show that we should be dosing intranasal insulin in spikes after meals when glucose spikes as well. Hyperinsulinemia (having more insulin relative to glucose) can cause glutamate toxicity.

 

I'm also wondering if a sharper insulin spike would increase insulin-degrading-enzyme more as well, and then when all the insulin is gone it remains to take care of the beta-amyloid that was created during the insulin spike.

 

We're seeing some somewhat conflicting results with intranasal insulin in some of the studies, showing that some people do well with it and some people don't. This is based on things like dose, whether or not they carry the apoe ε4 allele, and weight. I believe the negative effects seen in some of these studies have to do with the time the insulin is in the brain, the ratio of insulin to glucose in the brain, and that ratio over time. Perhaps there would be more stable amount of people benefiting from intranasal insulin if it was a rapid-acting insulin dosed after meals? And then from there people find their optimum dose. Insulin may not spike as sharply as body insulin after a meal, but there must be a spike of some sort after a meal and then a lull.

 

Any thoughts? Anyone else read into this at all?

 

musicman4534

[musicman4534]

Brain Insulin Receptor Causes Activity-Dependent Current Suppression in the Olfactory Bulb Through Multiple Phosphorylation of Kv1.3

 

D. A. Fadool, K. Tucker, J. J. Phillips, J. A. Simmen

 

 

However this study shows that insulin is high in the brain in between meals and very low right after a meal...

 

 

 

Our data suggest that there is a clear differential between the levels of insulin in the plasma and that found in the [Olfactory Bulb].

Our data indicate that insulin is elevated in the olfactory bulb after a 72-h fast.

 

 

So, would there be a problem with having high amounts of insulin in the brain during or right after a meal if hyperinsulinemia in the brain can cause susceptibility to toxins and stress?

SaveSave

Edited by musicman4534, 12 October 2016 - 09:53 PM.