2 replies to this topic

[cjgymrat]

I am hoping that someone smarter/ more knowledgable in neuropharmacology could help me out here.

Any potential danger in consuming SSRI's (specifically 5mg lexapro) l-theanine, and cannibus concurrently. A few days ago I experimented with this combo, and felt very nauseated, anxious, and overall a horrible since of malaise. This is interesting to me, considering marijuana has generally had the opposite effect on me, that is I generally feel an overall sense of well being from it.

Needless to say, I have resolved to indefinitely give up smoking. I am however worried that some sort of residual damage has using these substances in concert with one another. 3 days later I feel disassociated, slow, and discombobulated.

Any help would be greatly appreciated. I understand I was being somewhat reckless, and I am in remorse. I just want to know if there is any scientific basis to my worrying.

[Guardian4981]

Cannibus gave me the worst anxiety in my life, I have not researched it thouroughly but I think it gave me near serotonin syndrom as my symptoms were similar to when I took too much 5-htp just more severe.

From that standpoint it may be a bad idea to use an ssri with cannibus.

[cjgymrat]

I didn't think serotonin syndrome was possible with cannibus+ssri due to their varying mechanism of action (cannibus acting on the CB1 receptors, lexapro SERT receptor). Then again, I do not know, which is why I posted this thread.