http://www.ncbi.nlm....pubmed/22253980
Bovine colostrum supplementation during running training increases intestinal permeability.
Buckley JD, Butler RN, Southcott E, Brinkworth GD.
Source
Nutritional Physiology Research Centre, University of South Australia Adelaide, South Australia, 5000, Australia. jon.buckley@unisa.edu.au
Abstract
Endurance exercise training can increase intestinal permeability which may contribute to the development of gastrointestinal symptoms in some athletes. Bovine colostrum (BC) supplementation reduces intestinal permeability induced by non-steroidal anti-inflammatory drugs. This study aimed to determine whether BC could also reduce intestinal permeability induced by endurance exercise. Thirty healthy adult males (25.0 ± 4.7 yr; mean ± SD) completed eight weeks of running three times per week for 45 minutes at their lactate threshold while consuming 60 g/day of BC, whey protein (WP) or control (CON). Intestinal permeability was assessed at baseline and after eight weeks by measuring the ratio of urinary lactulose (L) and rhamnose ® excretion. After eight weeks the L/R ratio increased significantly more in volunteers consuming BC (251 ± 140%) compared with WP (21 ± 35%, P < 0.05) and CON (-7 ± 13%, P < 0.02). The increase in intestinal permeability with BC may have been due to BC inducing greater leakiness of tight junctions between enterocytes or by increasing macromolecular transport as it does in neonatal gut. Further research should investigate the potential for BC to increase intestinal macromolecular transport in adults.
This doesn't make sense to me. I know of atleast one study showing positive effects of bovine colostrum on gut permeability during heavy training (http://www.ncbi.nlm....pubmed/21148400), and I've seen it be highly recommended, particulary for gut issues. I feel it's helped me alot, especially with constipation, and along with digestive enzymes has completely eliminated my constant, severe bloating. However, this study is worrying given the supposedly large increase in permeability seen with colostrum compared to other groups. Whey Protien, I assume, should also help gut permeability due to glutamine content, however in this study it seems whey also increased permeability. And the control group saw a decrease in permeability? I'm not deeply informed on the science, so maybe I'm missing something. Would someone on this forum be able to clarify this study for me?
