24 replies to this topic

[Shadok]

Hello,

First of all, excuse my aweful english, I'm french, feel free to correct my synthax though :p.

My father as just been dignosted with a pancreatic cancer wich is surprising for us knowing his perfect lifestyle (a lot of sport + organic food, no milk, no gluten).

He wants to try starvation during his chemio (search Valter Longo), As an atentive reader of Longecity I have a lot of food suplements.

Could you help me on what I can give him ? ( I have alpha-lipoic acid, ALCAR, Resveratrol, alphaGPC, curcumin ).

Thanks a lot in advance !

[DePaw]

Rather than starving yourself look into ketogenic diets, which starve cancer cells while nourishing the rest of the body as cancer cells don't have functioning mitochondria they can't burn fat or ketones for energy, only glucose. So remove all glucose fuel and the cancer cells starve while the rest of the body has plenty of energy.

[YOLF]

Sorry to hear about your troubles. Cancer is a complex disease, you really need more information than just "has cancer of the..." Cancer is a broad term for many genetic abnormalities. Best to give us more information, see if you can get his blood test results and keep us up to date on the testing his docs are doing.

This says mitochonria can be active in cancer cells:
http://www.cancerres...ctive-in-cancer

Edited by cryonicsculture, 19 July 2013 - 11:47 AM.

[Shadok]

Thanks a lot for your anserws.
I didnt know about ketogenic diets, i'll do some research.
About the type of cancer, biopsie is done today, we'll results in about 10 days or so.

[Dorian Grey]

Google around on IP6 (Inositol Hexaphosphate).

Aside from glucose, cancer also must get the iron it needs from serum/plasma iron, and IP6 quickly snaps up and binds any free iron in blood plasma.

Most of the cancer research on IP6 has been done on with an IP6/inositol combination formula and there have been some remarkable success stories. I don't know why adding extra inositol to IP6 would be important as IP6 degrades into lower forms of inositol as it is metabolized, but this is what you'll find in the research. Perhaps the added inositol helps keep the IP6 from degrading too rapidly.

A rather expensive supplement called "IP6 Gold" is what's talked about most on the cancer forums, but IP6 Gold is a simple 1 part inositol to 4 parts IP6 which are both very cheap when purchased separately from what I gather.

IP6 must always be taken on a very empty stomach with a full glass of water for it to be effective... If taken with food, IP6 will simply bind minerals (including some important ones) in the meal, but get too loaded up with these minerals to take on extra iron in blood plasma. When taken properly, mega-doses are not required. Small doses taken frequently (half an hour before breakfast, lunch, dinner and before bed) will keep serum iron low and starve cancer of the iron it needs to grow.

IP6 also chelates magnesium and zinc, but as long as you take it well away from meals, deficiencies are not supposed to occur. Still, low dose supplementation of mag and zinc (taken with one meal per day) might be wise during aggressive IP6 therapy. Too much mag and zinc supplementation could reduce the effectiveness of IP6, so just a bit of these (very low dose) with one meal per day would seem wise.

Best of Luck to you both.

Edited by synesthesia, 20 July 2013 - 06:10 AM.

[zen]

Take a look on Manuka BIO30 propolis. It can't by itself cure the cancer but it can (according to research done by professor Maruta http://www.bio30.com...a-research.html) stop growth of certain types of cancer.
I usually buy it on Amazon.com http://www.amazon.co...0?ie=UTF8&psc=1

Edited by zen, 20 July 2013 - 04:23 PM.

[joelcairo]

All these articles relate to pancreatic cancer. Do your own research; these are publised scientific results, but are not guaranteed to be correct, or to be active in humans at clinically achievable doses, or to help you in particular.

I won't make specific recommendations, but IMO the core products for almost any cancer protocol include curcumin, quercetin, EGCG, sulforaphane and genistein. A possible exception is genistein for female hormone-driven cancers, but I'm not even sure about that.


NATURAL PRODUCTS.


Notch-1 down-regulation by CURCUMIN is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
http://onlinelibrary...cncr.21904/full
CURCUMIN induces apoptosis of pancreatic cancer cells by inhibiting Ras-ERK and Shh-GLI1 signal pathways
http://www.cjpp.net/...2012/V28/I6/996
Modulatory effects of CURCUMIN on multi-drug resistance-associated protein 5 in pancreatic cancer cells
http://www.springerl...u585716n215265/


Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
http://mct.aacrjourn...t/5/3/483.short


Diverse mechanisms of growth inhibition by LUTEOLIN, RESVERATROL, and QUERCETIN in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75
http://www.ncbi.nlm....les/PMC3383678/


RESVERATROL Inhibits Pancreatic Cancer Cell Proliferation through Transcriptional Induction of Macrophage Inhibitory Cytokine-1
http://www.phytochem...-anticancer.php


The Flavonoid QUERCETIN Inhibits Pancreatic Cancer Growth In Vitro and In Vivo
http://journals.lww....c_Cancer.7.aspx


SULFORAPHANE synergizes with QUERCETIN to inhibit self-renewal capacity of pancreatic cancer stem cells.
http://europepmc.org...ct/MED/21196331
SULFORAPHANE regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.
http://www.ncbi.nlm....pubmed/23129257


EGCG Inhibits Hsp90 Function by Impairing Hsp90 Association with Co-chaperones in Pancreatic Cancer Cell Line Mia Paca-2
http://www.ncbi.nlm....les/PMC2732434/
EGCG inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC-1 human pancreatic adenocarcinoma cells through the modulation of HDAC
http://www.ncbi.nlm....pubmed/23135610


Inhibitory effects of EGCG and PTEROSTILBENE on pancreatic cancer growth in vitro
http://www.sciencedi...02248041200385X


Epicatechin-rich COCOA polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model.
http://www.ncbi.nlm....pubmed/22190076


Drug From Chinese "THUNDER GOD VINE" [lei gong teng] [Tripterygium wilfordii] Slays Pancreatic Tumors in Mice
http://mobile.bloomb...rs-in-mice.html
"This drug is just unbelievably potent in killing tumor cells...You could see that every day you looked at those mice, the tumor was decreasing and decreasing, and then just gone."


WITHAFERIN A [from ASHWAGANDHA] Targets Heat Shock Protein 90 in Pancreatic Cancer Cells
http://www.ncbi.nlm....les/PMC2794909/


GRAVIOLA: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism
http://www.sciencedi...304383512002145


BAICALEIN, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells
http://www.sciencedi...167488911001327
The Bioflavonoid Baicalein Inhibits Human Pancreatic Cancer Cell Migration
http://www.deepdyve....ll-3lj2ndXhnA/1


CAPSAICIN Shows Promise In Inhibiting Growth Of Pancreatic Cancer
http://www.medicalne...eases/41022.php


DNA Fragmentation and Cell Cycle Arrest: A Hallmark of Apoptosis Induced by Crocin from Kashmiri SAFFRON in a Human Pancreatic Cancer Cell line
http://www.apocp.org...amid Bakshi.pdf
Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
http://mct.aacrjourn...t/8/2/315.short


Constituents of BRAZILIAN RED PROPOLIS and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition
http://www.mundialsi...onstituents.pdf


Selective Induction of Apoptosis and Autophagy Through Treatment With DANDELION ROOT EXTRACT in Human Pancreatic Cancer Cells
http://journals.lww....utophagy.8.aspx


Traditional Herbal Medicine [THYMOQUINONE, from NIGELLA SATIVA] Kills Pancreatic Cancer Cells, Researchers Report
http://www.scienceda...80519092215.htm


Popular Herbal Supplement [TRIPHALA] Hinders Growth Of Pancreatic Cancer Cells
http://www.scienceda...70417114757.htm


Effect of EICOSAPENTAENOIC ACID (EPA) AND OTHER FATTY ACIDS on the growth in vitro of human pancreatic cancer cell lines
http://www.ncbi.nlm....r00195-0030.pdf
Inhibition of proliferation by OMEGA-3 FATTY ACIDS in chemoresistant pancreatic cancer cells.
http://www.ncbi.nlm....pubmed/17896154


Grape Proanthocyanidin [GRAPESEED EXTRACT] Inhibit Pancreatic Cancer Cell Growth In Vitro and In Vivo through Induction of Apoptosis and by Targeting the PI3K/Akt Pathway
http://www.plosone.o...al.pone.0043064


PLUMBAGIN, a plant derived natural agent, inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-kappaB signaling pathways
http://onlinelibrary....27478/abstract


Revisiting the ALA/N (ALPHA-LIPOIC ACID/LOW-DOSE NALTREXONE) Protocol for People With Metastatic and Nonmetastatic Pancreatic Cancer: A Report of 3 New Cases
http://pbraunmd.org/...cer ala-ldn.pdf
The Long-term Survival of a Patient With Pancreatic Cancer With Metastases to the Liver After Treatment With the Intravenous a-Lipoic Acid/Low-Dose Naltrexone Protocol
http://ict.sagepub.c...nt/5/1/83.short


WHEATGERM AGGLUTININ-mediated toxicity in pancreatic cancer cells
http://www.ncbi.nlm....80-6690593a.pdf


FISETIN, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3 mediated inhibition of NF-kappaB
http://www.ncbi.nlm....les/PMC2944651/


Apigenin Inhibits the GLUT-1 Glucose Transporter and the Phosphoinositide 3-Kinase/Akt Pathway in Human Pancreatic Cancer Cells
http://journals.lww....sporter.14.aspx

[joelcairo]

PART 2: OFF-LABEL DRUGS


Combining betulinic acid and MITHRAMYCIN A effectively suppresses pancreatic cancer by inhibiting proliferation, invasion and angiogenesis
http://cancerres.aac...N-10-2016.short
Combined Treatment of Pancreatic Cancer with MITHRAMYCIN A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity
http://cancerres.aac...70/3/1111.short
Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells
http://www.biomedcen...71-2407/11/470/


Prevention of pancreatic cancer by the beta-blocker PROPRANOLOL
http://journals.lww....r_by_the.9.aspx


Lipoxygenase inhibitors [5-LOX AND 12-LOX INHIBITORS] abolish proliferation of human pancreatic cancer cells.
http://www.ncbi.nlm....pubmed/10405349


METFORMIN Treatment Caused Cancer Stem Cell Death in Pancreatic Cancer Cell Lines
http://www.aacr.org/...ses.aspx?d=2818
Old Wonder Drug [METFORMIN] for Pancreatic Cancer?
http://www.dailyrx.c...rd-chemotherapy
"When the widely-used diabetes drug, Metformin, was combined with standard chemotherapy, the combo therapy wiped out pancreatic cancer stem cells in one fell swoop, and they didn't come back."

N.B. I recommend experimenting with Metformin as a cancer treatment/preventative cancer ONLY in combination with statin drugs. Both have been associated with anticancer effect, but in the study below, Metformin plus statin use was associated with a huge reduction in prostate cancer risk (31%), however Metformin WITHOUT statin use resulted in a 115% INCREASE in prostate cancer risk. This may only apply to diabetics, but maybe not.

Statin Use as a Moderator of Metformin Effect on Risk for Prostate Cancer Among Type 2 Diabetic Patients
http://care.diabetes...5/1002.abstract

[zen]

_{I forgot to mention Ganoderma Lucidum which might also be worth to consider - http://suketuhealth....ma--cancer.html}

[Luminosity]

Pancreatin could help. If he's had surgery, chemo or radiation, check if it would be safe. You can take too much at a time so watch out. Enteric-coated ones are best. I like Nature's Plus brand which is available by mail order in the US from Vitacost and maybe Swansons. I think a healthy balanced diet would be best if he can digest it. I would limit or eliminate sugar and eat a steamed green vegetable every day. Chinese medicine is good. I have a thread about it here:

http://www.longecity...inese-medicine/

Edited by Luminosity, 21 July 2013 - 06:13 AM.

[suprdupracetam]

In David Schreiber's, m.d.,p.h.d., book 'anticancer: a new way of life'
there is a section on a pancreatic cancer patient who lived
for four years by eating some specific anti cancer foods with
every meal.

I think the film 'the gerson miracle' also has a 20 + year
pancreatic cancer survivor interview which is extremely unusual.

Also check out chrisbeatcancer.com

[Shadok]

Thank you all so much for your awnsers, I bought a lot of stuff, i'll tell you about the complete stack i made tomorow

[Matt]

look into AHCC http://en.wikipedia....elated_Compound

http://www.ahccresea...m/research.html

Edited by Matt, 25 July 2013 - 05:50 PM.

[Shadok]

Hi guys, I'm currently reading everything I can, i'll probably by some other stuffs later.
Here's what I have so far:

Curcumin (high bioavailable formula with clinical tests)
Resveratrol
ALA
IP6 (inositol hexaphosphate)
Sulforaphane glucosinate
Omega 3
Reishi extracts
Red propolis

I'm not pretty sure about dosage though, I'm searching about that,


___________________________________

Edit:
IP6 => I have 800 mg caps, i've seen somewhere that 500mg twice a day is efficient enought, i've seen: http://www.diagnose-...aphosphate.html . Does anyone have a reliable information about that ?

Edited by Shadok, 26 July 2013 - 11:10 AM.

[tham]

I think you should ask him to take lots of pterostilbene and blueberries as well.

http://www.doctorvit...tilbenePg1.html


Pterostilbene has a far longer half-life, bioavailability and blood-brain barrier
penetration than resveratrol, which has been disappointing in cancer in vivo,
despite massive amounts.


Genomic analysis of pterostilbene predicts its antiproliferative effects against
pancreatic cancer in vitro and in vivo.

http://www.ncbi.nlm....pubmed/22450950


Pterostilbene inhibits pancreatic cancer in vitro.

http://www.ncbi.nlm....pubmed/20140535


Blueberries' main anticancer component is pterostilbene, but
part of it also comes from delphinidin.


Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces
apoptosis and cell cycle arrest in human colon cancer HCT116 cells.

http://www.ncbi.nlm....pubmed/18729103



Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables:
a new weapon to blunt prostate cancer growth.

http://www.ncbi.nlm....pubmed/18948740




Delphinidin is also found in high amounts in the butterfly pea,
and is mainly responsible for its deep blue color.

http://en.wikipedia....itoria_ternatea


Soak the flowers in hot water, and you'll extract its blue dye easily.

http://en.wikipedia....itoria_ternatea


It's a creeper and apparently grows fast.

http://www.thompson-...rfly-pea/4663TM



The Kelantanese Malays of Malaysia use this flower, which they call "bunga telang",
extensively to color their rice and rice cakes, but they don't realize that the blue
color is a powerful cancer fighter.

http://jewelpie.com/...fly-pea-flower/


http://www.etsy.com/...fly-pea-flowers



http://www.youtube.com/watch?v=kAizYA5os90

Edited by tham, 30 July 2013 - 12:51 PM.

[tarasco]

Try Googling Liposomal Vitamin C

There is a long and comprehensive and important thread on the ATS site....it's a Conspiracy Theory site but the Liposomal Vitamin C thread is a jewell....

Think Linus Pauling...Vitamin C...Cancer....then multiply by 1000.(a tiny bit of hyperbole)

I just started it three weeks ago for immune problems and its even working for me....though, in the above thread are much more remarkable experiences....

Safe & likely effective for all....

Tarasco

[theconomist]

Hey, I second fasting before,during and after chemo.
Best of luck and keep us updated.

[DePaw]

Vitamin B17 as apricot kernels. It contains cyanide but only cancer cells have the enzyme to release it, so it kills cancer cells and not healthy cells. It's also very good at improving appetite and nausea in cancer patients.

[theconomist]

Vitamin B17 as apricot kernels. It contains cyanide but only cancer cells have the enzyme to release it, so it kills cancer cells and not healthy cells. It's also very good at improving appetite and nausea in cancer patients.

Wasn't this proven as ineffective? or is it one of those controversial things which may/may not work?

http://www.cancerres...rapies/laetrile

http://worldwithoutc...rg.uk/hoax.html

http://www.sciencema...t/198/4323/1231

[zorba990]

Sodium butyrate (Especially if getting loose stool from other supplements)
http://www.ncbi.nlm....pubmed/16109447

[DePaw]

Sodium butyrate (Especially if getting loose stool from other supplements)
http://www.ncbi.nlm....pubmed/16109447

Butter is the best dietary source of butyrate (3.2% of the fatty acids), even named after being in butter.

[zorba990]

Sodium butyrate (Especially if getting loose stool from other supplements)
http://www.ncbi.nlm....pubmed/16109447

Butter is the best dietary source of butyrate (3.2% of the fatty acids), even named after being in butter.

For chemo therapeutic results I would go with 6-12 of these per day (work up to it) http://www.needs.com...100/b_TE_Neesby
I would doubt butter would provide enough to get a medical result, but might be a reasonable preventative.

[Shadok]

Sodium butyrate (Especially if getting loose stool from other supplements)
http://www.ncbi.nlm....pubmed/16109447

Butter is the best dietary source of butyrate (3.2% of the fatty acids), even named after being in butter.

For chemo therapeutic results I would go with 6-12 of these per day (work up to it) http://www.needs.com...100/b_TE_Neesby
I would doubt butter would provide enough to get a medical result, but might be a reasonable preventative.

It seems great, but despite my intesive googling, i'm unable to find any site who send it to france :/

[DePaw]

Just eat plenty of butter then!

[ta5]

Anticancer Drugs. 2013 Jun;24(5):504-18.


Molecular analysis of the inhibitory effect of N-acetyl-L-cysteine on the proliferation and invasiveness of pancreatic cancer cells.

Mezencev R, Wang L, Xu W, Kim B, Sulchek TA, Daneker GW, McDonald JF.
School of Biology and the Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology

Preliminary studies have suggested that the reactive oxygen species (ROS) scavenger N-acetyl-L-cysteine (NAC) may be effective in inhibiting the growth of pancreatic cancer cells. In-depth cellular and molecular analyses were carried out to determine NAC's mode of action in inhibiting the growth of a well-characterized pancreatic cancer cell line (AsPC-1). Standardized assays were used to monitor cellular growth, apoptosis, levels of ROS, cellular senescence, migration, and invasiveness. Cell stiffness was measured using atomic force microscopy. Gene expression was monitored by quantitative PCR. NAC significantly inhibits the growth and metastatic potential of AsPC-1 cells by inducing cell-cycle arrest in G1 and subsequent cellular senescence and decreased invasiveness. These anticancer properties are associated with an unexpected increase in the intracellular concentrations of ROS. NAC does not decrease the susceptibility of AsPC-1 cells to the anticancer drugs gemcitabine, mitomycin C, and doxorubicin. NAC-induced changes in gene expression are consistent with the onset of mesenchymal-to-epithelial transition. In conclusion, our findings indicate that NAC induces an integrated series of responses in AsPC-1 cells that make it a highly promising candidate for development as a pancreatic cancer therapeutic.
PMID: 23511429