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#151 gregmacpherson

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Posted 15 March 2016 - 08:48 PM

Yes, still here! Just been a little quiet of late because of my work load.  Its been a very busy time. 

 

Lots happening in terms of human research across fibromyalgia, cardiovascular health, MS, kidney health, metabolic function and lung health.   I will post as an when the research is published.  There will be some this year and some next.  

 

If you take a look at pubmed.com and search MitoQ you will see some of the other research that has recently been published.  

 

And our big news from 2015 was that we were selected for the NIA's Intervention Testing Program - an independent anti-aging research programme. 

 

Re discounts ... we have a discount of 15% available to paid members of Longecity. 

 

Thanks, Greg


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#152 Daniel Cooper

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Posted 25 March 2016 - 01:54 PM


 

Re discounts ... we have a discount of 15% available to paid members of Longecity. 

 

Thanks, Greg

 

Greg,

 

How does a paid member get access to the discount code?



#153 gregmacpherson

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Posted 30 March 2016 - 06:08 AM

 


 

Re discounts ... we have a discount of 15% available to paid members of Longecity. 

 

Thanks, Greg

 

Greg,

 

How does a paid member get access to the discount code?

 

 

Hi Daniel, please contact the LongeCity admin team and they will be able to give it to you. 

 

thanks

 

Greg


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#154 bosharpe

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Posted 23 May 2016 - 07:03 PM

Did anyone ever see Vladimir Skulachev's comment on MitoQ on this longevity blog:

 http://joshmitteldor...coq10/#comments

 

Greg, have you any response to the Dr's comments regarding his first paragraph? 



#155 gregmacpherson

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Posted 24 May 2016 - 04:26 AM

Hi, yes a few comments on Skulachev's notes.  Skulachev is a smart chap who knows his way around MitoQ well so I was a little disappointed with his response as it was a touch misleading. We think Skulachev has an interesting compound in SKQ1 and follow his work. 

 

However, to clarify;

 

1. MitoQ is CoQ10 with a positive charged added causing it to target the negatively charged mitochondria

2. CoQ10 has two functions - it is an integral part of the electron transport chain (ETC) and it is an antioxidant that mops up the free radicals generated by the ETC in the process of generating ATP

3. MitoQ, because of the addition of the positive charge is not active in the ETC. Its effect primarily comes down to its effectiveness as an antioxidant and its ability to embed itself into and stabilise the inner mitochondrial membrane.  In so doing MitoQ supports all of the activity that is carried out within this membrane which includes supporting the multi complex ETC. So, albeit indirectly, MitoQ supports the generation of ATP with the side benefit of positively enhancing membrane function and all the activity that goes with it.  

4. MitoQ is effectively a highly bio-available form of CoQ10 and there is absolutely no issue with respect to pro-oxidant risk which makes sense given it is the same antioxidant moiety as CoQ10. 

5. You cannot compare plant cells with mammalian cells. 

 

All of the above has been evaluated and confirmed across a number of independent researchers over the years. 

 

For those of you who enjoy a deep dive into the research please visit pubmed and search for MitoQ.  It will give you a view on the potential of the compound and the latest research.

 

In terms of anti-aging, MitoQ was selected into the Interventions Testing Programme 2015 cohort.  Unfortunately we need to wait a few years for the results but the bar is relatively high to get into this programme and only compounds with significant anti-aging potential are accepted. 

 

We have a bunch of human research happening in the wings.  Most of it is independent of us other than we supplied the capsules and placebo. 

 

Interesting times here as more and more knowledge is generated with respect to the link between mitochondrial function and healthy aging. More to come as I am able to share. 

 

Essentially if we can "tune up" the mitochondria we are replicating the higher energy environment that is seen in younger cells. Cells are self repairing machines - giving them the energy they need to operate at that level can only be a good thing. 

 

Thanks and with regards

 

Greg


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#156 bosharpe

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Posted 26 May 2016 - 04:57 PM

Thanks Greg.



#157 Kalliste

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Posted 26 May 2016 - 08:37 PM

Well I found a bottle from last summer with one 5mg pill left. I come of as a commercial now but that pill alone was enough to make me swallow the $60 cost of a bottle + Swe shipping. It really gets me going, followed a 20km local half marathon on bike with my son on the back and then hit the gym for an hour with a lot of energy.

 

I've been drinking beetroot juice and eating sodium bicarbonate aswell but those things alone didn't give that buzz.

Going to try this combo again, the effect seemed to stay with me for two or almost three days. Hrmm that was a nice experience. Def one of my most intense workout days in a long time.



#158 bosharpe

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Posted 28 May 2016 - 05:14 PM

Bought a bottle of Mitoq. Will report back here after dosing.



#159 bosharpe

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Posted 19 June 2016 - 10:44 AM

I received the Mitoq. Initially I took 1 cap per day for 5 days. YEsterday I took two and noticed a dramatic boost in energy levels and mental clarity for several hours. I was buzzing! I've taken another 2 today and not so much of an effect, in fact I can't be certain I feel much of a buzz at all. 



#160 Graviton

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Posted 27 June 2016 - 01:54 PM

greg,

how can you be sure that Mitoq skin serum can be absorbed into skin through its barriers, and then it can reach to its mitochondria?



#161 gregmacpherson

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Posted 27 June 2016 - 11:27 PM

greg,

how can you be sure that Mitoq skin serum can be absorbed into skin through its barriers, and then it can reach to its mitochondria?

 

Hi Graviton, 

 

We have done testing called Franz diffusion cell testing which measures the delivery of MitoQ across the layers of the skin and this shows that it reaches the dermis in levels high enough to be active. From there it migrates directly to the mitochondria per our mitochondria-targeting technology i.e. the positive charge on MitoQ is attracted to the negative charge within the mitochondria.  

 

Thanks. 



#162 Graviton

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Posted 29 June 2016 - 06:32 AM

 

greg,

how can you be sure that Mitoq skin serum can be absorbed into skin through its barriers, and then it can reach to its mitochondria?

 

Hi Graviton, 

 

We have done testing called Franz diffusion cell testing which measures the delivery of MitoQ across the layers of the skin and this shows that it reaches the dermis in levels high enough to be active. From there it migrates directly to the mitochondria per our mitochondria-targeting technology i.e. the positive charge on MitoQ is attracted to the negative charge within the mitochondria.  

 

Thanks. 

 

 

1. What about the stability and bioavailability of MitoQ? Is each capsule enteric coated? I am concerned about degradation of Mitoq by stomach acid, and I would like to know if I have to encapsulate separate MitoQ capsules with stomach acid protected capsules again.

2. Should I take MitoQ with food or in an empty stomach?

3. Can I take general advantages of MitoQ as described in MitoQ web-site if I am in early 20s? i.e. I wonder if Mitoq can fully act for young individuals who have sufficient amount of CoQ10, as it usually do to elderly people.

4. Any known UPDATED interactions with other supplements including C60, NR, pqq? (it has been asked before in this thread, but just to check any updates)

5. If taken sublingually, any toxicity or harms? (for example, from absorption of excipient materials etc) 


Edited by Graviton, 29 June 2016 - 06:50 AM.


#163 Kalliste

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Posted 29 June 2016 - 03:49 PM

 

 

greg,

how can you be sure that Mitoq skin serum can be absorbed into skin through its barriers, and then it can reach to its mitochondria?

 

Hi Graviton, 

 

We have done testing called Franz diffusion cell testing which measures the delivery of MitoQ across the layers of the skin and this shows that it reaches the dermis in levels high enough to be active. From there it migrates directly to the mitochondria per our mitochondria-targeting technology i.e. the positive charge on MitoQ is attracted to the negative charge within the mitochondria.  

 

Thanks. 

 

 

1. What about the stability and bioavailability of MitoQ? Is each capsule enteric coated? I am concerned about degradation of Mitoq by stomach acid, and I would like to know if I have to encapsulate separate MitoQ capsules with stomach acid protected capsules again.

2. Should I take MitoQ with food or in an empty stomach?

3. Can I take general advantages of MitoQ as described in MitoQ web-site if I am in early 20s? i.e. I wonder if Mitoq can fully act for young individuals who have sufficient amount of CoQ10, as it usually do to elderly people.

4. Any known UPDATED interactions with other supplements including C60, NR, pqq? (it has been asked before in this thread, but just to check any updates)

5. If taken sublingually, any toxicity or harms? (for example, from absorption of excipient materials etc) 

 

 

1. I think it has good stability, I've eaten it on empty stomach, eaten it with dairy and coffee (both of which can disturb some polyphenols and vitamin absorption). You do not need to modify the pill.

 

2. I've mostly taken it with food so why not do that.

 

3. I took it the first time last year, took 10mg in the morning, when I was 32. I was riding bike 100km/week when I started taking it and had been doing that for a year + eating lots of health stuff so I was in good condition.

Yet MitoQ had a pronounced effect, right away a few hours after the first dose.

That effect can very much be described as "more energy for stuff". Training in the gym, riding my bike, playing with my son, and some weird stuff like brushing my teeth really really hyper carefully.

I've taken a lot of supplements throughout the years expecting good results, but never experienced this effect as remarkably. Not even with 5ml C60oo every day for a while (tried VW and C60oliveoil.com), nor did CoQ10 at dosages of up to 200mg/day do anything noticeable.

 

4. What tox-concerns I know of:

- Could disturb MitoROS normally used to direct stem cell activity.

- Could disturb hormetic effects of exercise mediated by increased mtROS production.

 

5. I never tried taking it sublingually because oral administration worked wonders.

 

The only negative for me is that cost+shipping is $60. If it was cheaper I would like to take more.

 

One weird effect (not so weird if you plow through Lostfalcos Nootropic thread) is that MitoQ has a clearly noticeable psychological effect: It makes me markedly more outgoing and talkative. Falco has more on that, mitos play a central function in our brains so if you change them it follows that should literally change your mindstate.



#164 Graviton

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Posted 29 June 2016 - 06:01 PM

 

 

 

greg,

how can you be sure that Mitoq skin serum can be absorbed into skin through its barriers, and then it can reach to its mitochondria?

 

Hi Graviton, 

 

We have done testing called Franz diffusion cell testing which measures the delivery of MitoQ across the layers of the skin and this shows that it reaches the dermis in levels high enough to be active. From there it migrates directly to the mitochondria per our mitochondria-targeting technology i.e. the positive charge on MitoQ is attracted to the negative charge within the mitochondria.  

 

Thanks. 

 

 

1. What about the stability and bioavailability of MitoQ? Is each capsule enteric coated? I am concerned about degradation of Mitoq by stomach acid, and I would like to know if I have to encapsulate separate MitoQ capsules with stomach acid protected capsules again.

2. Should I take MitoQ with food or in an empty stomach?

3. Can I take general advantages of MitoQ as described in MitoQ web-site if I am in early 20s? i.e. I wonder if Mitoq can fully act for young individuals who have sufficient amount of CoQ10, as it usually do to elderly people.

4. Any known UPDATED interactions with other supplements including C60, NR, pqq? (it has been asked before in this thread, but just to check any updates)

5. If taken sublingually, any toxicity or harms? (for example, from absorption of excipient materials etc) 

 

 

1. I think it has good stability, I've eaten it on empty stomach, eaten it with dairy and coffee (both of which can disturb some polyphenols and vitamin absorption). You do not need to modify the pill.

 

2. I've mostly taken it with food so why not do that.

 

3. I took it the first time last year, took 10mg in the morning, when I was 32. I was riding bike 100km/week when I started taking it and had been doing that for a year + eating lots of health stuff so I was in good condition.

Yet MitoQ had a pronounced effect, right away a few hours after the first dose.

That effect can very much be described as "more energy for stuff". Training in the gym, riding my bike, playing with my son, and some weird stuff like brushing my teeth really really hyper carefully.

I've taken a lot of supplements throughout the years expecting good results, but never experienced this effect as remarkably. Not even with 5ml C60oo every day for a while (tried VW and C60oliveoil.com), nor did CoQ10 at dosages of up to 200mg/day do anything noticeable.

 

4. What tox-concerns I know of:

- Could disturb MitoROS normally used to direct stem cell activity.

- Could disturb hormetic effects of exercise mediated by increased mtROS production.

 

5. I never tried taking it sublingually because oral administration worked wonders.

 

The only negative for me is that cost+shipping is $60. If it was cheaper I would like to take more.

 

One weird effect (not so weird if you plow through Lostfalcos Nootropic thread) is that MitoQ has a clearly noticeable psychological effect: It makes me markedly more outgoing and talkative. Falco has more on that, mitos play a central function in our brains so if you change them it follows that should literally change your mindstate.

 

 

If MitoQ "Could disturb MitoROS normally used to direct stem cell activity,

  Could disturb hormetic effects of exercise mediated by increased mtROS production", it mgiht be a concern.

C60 seems to work as a hormetic pathway, and PQQ is known to upregulate some hormetic gene expressions. Not only that, other supplements such as curcumin, silymarin are generally known as a nrf2, sirt1 activator. This pathway is usually realized by imposing a little harm, then taking benefits from repair responses. If MitoQ merely acts as a direct ROS scavenging agent, there would be some concerns regarding to those gene expression in the mitochondria level.

Although the claim that taking commercial hormetic supplements can lead to a longevity in mammals is still unclear, I wonder the impacts of MitoQ on various longevity related gene expression in regard to how it regulate them.

Also, how can MitoQ affect on glycolysis, Krebs cycle, and electron transport chain? What about the change on their feedback loops?

 

Mixed herb extracts or single extract from botanical compounds failed to extend the lifespan of mouses in the study (http://www.ncbi.nlm....les/PMC4039264/, http://www.ncbi.nlm....ubmed/22451473) while some mixture of nrf2 activating herbal extracts seems to work for male mice to increase a bit of longevity (http://www.ncbi.nlm.nih.gov/pubmed/27312235).

As I guess, there is a study MitoQ supplemented mice(don't know if it is healthy mice or genetically issued) has about 6% increased (either maximum or mean) lifespan. And, MitoQ supplemented mice has better endogenous antioxidants' status(glutathione, SOD ...). I need to study a little more before taking them and get some more information.

 


Edited by Graviton, 29 June 2016 - 06:22 PM.


#165 sthira

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Posted 29 June 2016 - 06:28 PM

greg,
how can you be sure that Mitoq skin serum can be absorbed into skin through its barriers, and then it can reach to its mitochondria?


Hi Graviton,

We have done testing called Franz diffusion cell testing which measures the delivery of MitoQ across the layers of the skin and this shows that it reaches the dermis in levels high enough to be active. From there it migrates directly to the mitochondria per our mitochondria-targeting technology i.e. the positive charge on MitoQ is attracted to the negative charge within the mitochondria.

Thanks.

Ingredients: Aqua, Cetearyl Alcohol, Behentrimonium Methosulfate, Dicapryl Carbonate, Glycerin, Mitoquinol Mesylate, Potassium Sorbate, Phenoxyethanol 



For skin, doesn't plain ole normal ubiquinone find its way easily into mitochondria? It would not be good if MitoQ serum's "Mitoquinol Mesylate" caused the body to recognize our own ubiquinone as an invader. Has anyone developed allergies from this serum yet?

Are there any safety studies regarding regular use of this? It's been on retail for several years.

#166 gregmacpherson

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Posted 29 June 2016 - 08:14 PM


 


 

1. What about the stability and bioavailability of MitoQ? Is each capsule enteric coated? I am concerned about degradation of Mitoq by stomach acid, and I would like to know if I have to encapsulate separate MitoQ capsules with stomach acid protected capsules again.

 

MitoQ has been extensively studied through to Phase II clinical level.  There are no issues with stability/bioavailability nor with degradation by stomach acid. 

 

2. Should I take MitoQ with food or in an empty stomach?

 

For better results take on an empty stomach. 

 

3. Can I take general advantages of MitoQ as described in MitoQ web-site if I am in early 20s? i.e. I wonder if Mitoq can fully act for young individuals who have sufficient amount of CoQ10, as it usually do to elderly people.

 

A good question; as long as you don't have any conditions associated with mitochondrial dysfunction you are unlikely to get much benefit from MitoQ in your 20s because you have adequate mitochondrial function and CoQ10 levels.  We recommend it from your 30s.  That said, if you are going through a period of high stress, illness or over indulgence then MitoQ can help in your 20s.

 

4. Any known UPDATED interactions with other supplements including C60, NR, pqq? (it has been asked before in this thread, but just to check any updates)

 

No known interactions.   

 

5. If taken sublingually, any toxicity or harms? (for example, from absorption of excipient materials etc) 

 

Not that we are aware of. 



#167 gregmacpherson

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Posted 29 June 2016 - 08:20 PM

 


Ingredients: Aqua, Cetearyl Alcohol, Behentrimonium Methosulfate, Dicapryl Carbonate, Glycerin, Mitoquinol Mesylate, Potassium Sorbate, Phenoxyethanol 



For skin, doesn't plain ole normal ubiquinone find its way easily into mitochondria? It would not be good if MitoQ serum's "Mitoquinol Mesylate" caused the body to recognize our own ubiquinone as an invader. Has anyone developed allergies from this serum yet?

Are there any safety studies regarding regular use of this? It's been on retail for several years.

 

 

Ubiquinol is synthesised inside the mitochondria and does not cross membranes easily.  Ubiquinone taken as a supplement has very low penetration in to the mitochondria.   This is why MitoQ is such a breakthrough as it is able to cross membranes and accumulates in the mitochondria improving their antioxidant capacity and stabilising the mitochondrial membrane.

 

No issues regarding sensitisation over the past 4 years.   We have over 100,000 patient months in market. 

 

Thanks







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