The high majority of NSI-189 user report taking it BID (twice a day) and I can't find the source for this indication.
The Neuralstem papers, I've seen, talk about total dose for a day but doesn't specify if the total qty was administered in divided doses.
Also, I also failed to find the indication for taking it sublingually. Did I miss a paper?
This seems to me as very important for the following reasons.
According to a Neuralstem paper, the 40mg/day and 80mg/day did not only better than the 120mg/day, but the 120mg/day didn't produced ANY reduction of cognitive impairment and depression. Now, if they didn't took it sublingually and we do, our sublingual 40mg/day or 80mg/day could amount to blood levels way higher; perhaps up with oral (not-sublingual) 120mg/day or possibly even higher. This could make us miss the good spots on the U-shaped curve.
Now, about the daily dosage division, if Neuralstem didn't test NSI-189 BID or TID, we can't assume NSI-189 their results would have been positive if they divided the dosage. Some drugs mechanism of action could depend on a pulsating pattern that isn't satisfied by BID or TID dosing.
Having no idea of how this drug works, I'd rather take it exactly like those trials participant.
Any source for BID/TID and sublingual vs Oral?