6 replies to this topic

[mealz13]

Hello everyone,

 

   I have been posting on other forums lately about how to naturally treat some issues I have, and after a lot of research I think I have finally consolidated my thoughts into two specific questions:

 

*Are all amino acid supplements to be avoided when trying to limit mTOR activity, lower IGF-1, etc.?  From what I can gather, these amino acids stimulate mTOR: methionine, cysteine, tryptophan, arginine, lysine, leucine, taurine.  However, although I could not turn up any evidence that glycine and histidine were harmful, or in other words, as stimulating as other aminos, I still have my doubts, as aren't all amino acids involved in at least some form of mTOR stimulation, IGF-1/ HGH raising, etc?  The reason I ask about these two specifically is because I want to try glycine for anxiety, and histidine helps my joints.  I know glycine can scavenge Met from the system, but does this property outweigh the effect it may have on mTOR, if any?

 

*Some other supplements, namely ALCAR, creatine, CDP-choline, phosphatidylserine, among others, seem to have effects on mTOR/IGF-1/HGH/Autophagy etc. (I can link some studies if there is disagreement about this).  However, much to my dismay, these studies seem to not specify how much these supplements impact these aspects.  I am a worry wort and worry that if I try ALCAR, for example, it will help my cognition, only to lower my chances of living longer, and I value life extension more than I do cognitive enhancement.  So, in other words, are supplements like the ones listed above any cause for concern, given that they can (although not known to what extent) influence some of the only things we know affect longevity?  Would it be wise to not supplement with something if it is indicated in affecting any one of these aspects, even if it may be minor, from a life extension point of view?

 

Thanks all.

[niner]

mealz, I'm pleased to hear you bring up the concept of magnitude of effect.  Too many people on Longecity get themselves all tied up in knots over some compound or other's supposed negative effect, and don't stop to consider that they would need to take a massive dose in order to have any chance of observing that effect.    Or they waste money on some supplement because a Pubmed abstract reported that it did something useful.  The problem is that too many of those Pubmed reports are based on simple experiments where naked cells are soaked in a concentrated solution of said supplement for a couple days.  Such experiments usually have little or no bearing on how the compound will act in the body.

 

I really don't think you need to worry at all about Gly, His, or ALCAR at normal supplemental dosages.   I would worry more that you aren't getting enough protein in your diet.  You're young, and the future is looking very bright indeed for rejuvenative medicine.   I think it's more important to get your anxiety under control and deal with the joint problem.  What are the symptoms of your joint problem?  Do you know what causes it?  His is not a typical treatment for joint issues, but there are a lot of approaches that work very well.

[sensei]

 

 

I really don't think you need to worry at all about Gly, His, or ALCAR at normal supplemental dosages.   I would worry more that you aren't getting enough protein in your diet.  

 

Strenuous resistance training coupled with Testosterone Replacement Therapy (which for me  = proper hormonal balance ) has made my overall quality of life and health fantastic -- including mood.

 

I eat 1 gram of protein per pound of body weight per day AT LEAST!  This equals about 180 - 190 grams per day.

 

The difference in energy, recovery, and feeling of general well being is drastically different than when I was consuming a 'normal' amount of protein ( .5 grams per pound per day).

 

For the record -- I also eat a very low carb diet -- right now I am cutting fat and balancing that with anabolic gains -- so a ketotic diet of 40% pro - 50% fat - no more than 10% carbs  is what I'm on. (less than 50 grams carbs /day)

 

It is fun to eat a "diet meal" that consists of half a package of bacon, half a dozen jumbo eggs smothered with cheese and 2 avocados.  -- FYI out of the approximately 1500 calories in that meal there are 10 grams of carbs/sugar -- from the avocados ; about 70-75 grams of protein and the rest are fats.  umm umm goood!

 

The rest of my protein comes throughout the day from shakes/supps (zero - x low sugar) that I mix with plain no-carb psyllium husk fiber.

Edited by sensei, 20 March 2015 - 11:45 AM.

[Dallasboy]

What TRT routine are you on?

[sensei]

What TRT routine are you on?

 

10% compounded Testosterone Cream 100mg/gr -- 1 gram daily applied topically.

 

I started about 8 weeks ago

 

Prior to starting TRT my free T was ~6.0 and my total was ~400 --- the levels of an average 75 year old man.

[Dallasboy]

What TRT routine are you on?

10% compounded Testosterone Cream 100mg/gr -- 1 gram daily applied topically.

I started about 8 weeks ago

Prior to starting TRT my free T was ~6.0 and my total was ~400 --- the levels of an average 75 year old man.

What's your TT and FT now? E2? And I see you goto a compounding pharmacy, I assume your TRT doc gives you a script for that? Take any HCG as well or an AI?

Edited by Chris Adams, 21 March 2015 - 12:53 PM.

[sensei]

My blood was just taken for labs,liver enzymes. I'll know in a week or 2. No aromatase inhibitors or hcg, No gyno at all.