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Effects of resveratrol on older rat brain

resveratrol in vivo brain

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#1 malbecman

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Posted 25 January 2016 - 04:37 PM

 Promising sounding results for this in vivo study.


Synapse. 2016 Jan 20. doi: 10.1002/syn.21888. [Epub ahead of print]

Chronic administration of resveratrol prevents morphological changes in prefrontal cortex and hippocampus of aged rats.

Resveratrol may induce its neuroprotective effects by reducing oxidative damage and chronic inflammation apart from improving vascular function and activating longevity genes, it also has the ability to promote the activity of neurotrophic factors. Morphological changes in dendrites of the pyramidal neurons of the prefrontal cortex (PFC) and hippocampus have been reported in the brain of aging humans, or in humans with neurodegenerative diseases such as Alzheimer's disease. These changes are reflected particularly in the decrement of both the dendritic tree and spine density. Here we evaluated the effect of resveratrol on the dendrites of pyramidal neurons of the PFC (layers 3 and 5), CA1- and CA3-dorsal hippocampus (DH) as well as CA1-ventral hippocampus, dentate gyrus (DG) and medium spiny neurons of the nucleus accumbens of aged rats. 18-month-old rats were administered resveratrol (20 mg/kg, orally) daily for 60 days. Dendritic morphology was studied by the Golgi-Cox stain procedure, followed by Sholl analysis on 20 month old rats. In all resveratrol-treated rats, a significant increase in dendritic length and spine density in pyramidal neurons of the PFC, CA1 and CA3 of DH was observed. Interestingly, the enhancement in dendritic length was close to the soma in pyramidal neurons of the PFC, whereas in neurons of the DH and DG, the increase in dendritic length was further from the soma. Our results suggest that resveratrol induces modifications of dendritic morphology in the PFC, DH and DG. These changes may explain the therapeutic effect of resveratrol in aging and in Alzheimer's disease. This article is protected by copyright. All rights reserved.

© 2016 Wiley Periodicals, Inc.


Keys word: aging; Resveratrol; dendritic morphology; hippocampus; neuronal plasticity; nucleus accumbens; prefrontal cortex

PMID: 26789275

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#2 maxwatt

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Posted 26 January 2016 - 04:17 PM

Another case in point: Resveratrol may not increase potential lifespan, but it seems to prevent many of the things that otherwise shorten it or make it not worth living.

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#3 Logic

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Posted 27 January 2016 - 12:46 AM

Another case in point: Resveratrol may not increase potential lifespan, but it seems to prevent many of the things that otherwise shorten it or make it not worth living.


...The IC50 values for 2,3,5,4′-tetrahydroxystilbene 2-O-β-D-glucopyranoside in inhibiting lipid peroxide formation in liver, heart and brain were 13.68, 16.34 and 17.62 µg/mL, respectively. It was shown that Stilbene glycosides from Polygonum multiflorum has a better antioxidant potency than that of resveratrol.



...We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a cell-free assay and in the nematode. The antioxidative capacity was even higher compared to resveratrol. Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly. TSG increased the resistance of C. elegans against lethal thermal stress more prominently than resveratrol (50 μM TSG increased mean survival by 22.2%). The level of the ageing pigment lipofuscin was decreased after incubation with the compound. TSG prolongs the mean, median, and maximum adult life span of C. elegans by 23.5%, 29.4%, and 7.2%, respectively, comparable to the effects of resveratrol...



This study found that 2,3,5,4′-tetrahydroxystilbene 2-O-β-d-glucoside (THSG), the major bioactive compound from Polygonum multiflorum Thunb., can efficiently inhibit the formation of AGEs in a dose-dependent manner by trapping reactive MGO under physiological conditions (pH 7.4, 37 °C). More than 60% MGO was trapped by THSG within 24 h, which was much more effective than resveratrol and its methylated derivative, pterostilbene, the two major bioactive dietary stilbenes. The major mono- and di-MGO adducts of THSG were successfully purified and found to be mixtures of tautomers. LC-MS and NMR data showed that positions 4 and 6 of the A ring were the major active sites for trapping MGO. It was also found that THSG could significantly inhibit the formation of AGEs in the human serum albumin (HSA)−MGO assay and both mono- and di-MGO adducts of THSG were detected in this assay using LC-MS. The results suggest that the ability of THSG to trap reactive dicarbonyl species makes it a potential natural inhibitor of AGEs.





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#4 irony

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Posted 02 May 2016 - 07:49 PM

if anyone wants the full article, you can download the pdf here:   https://we.tl/KOG54gRpWA


(yeah, the link looks sketchy - it is not)

Also tagged with one or more of these keywords: resveratrol, in vivo, brain

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