OK, I don't expect magic, but this does say what I think it says.
- It causes donor beta cells to grow from 60+ year old HUMAN donors.
- It is supported by 2 more studies, one recent.
- It is ~25% orally available.
I now see 3 credible papers saying a natural DYRK1A inhibitor makes HUMAN beta cells enter cell cycle "at potentially therapeutic range":
Following PPX, mice were allowed to recover for 24 hours, and then further randomized to receive vehicle (saline) or 10 mg kg−1 harmine HCl by intraperitoneal injection daily for 7 or 14 days.
Harmine not only induces markers of proliferation in rat, mouse and human beta cells in vitro, it also increases beta cell mass and regeneration in a mouse PPX model, and enhances glycemic control and beta cell proliferation in vivo in two additional standard human islet transplant models, one euglycemic and one diabetic.
In summary, harmalogs are able to induce adult human beta cell cycle entry at rates that are in the physiologic and potentially therapeutic range. Further approaches to optimizing the potency of the harmalog backbone, of unequivocally defining its molecular target(s), and of developing methods to direct it specifically to the beta cell are important future challenges.
Harmine HCl is ~25% orally available. What is 10 mg / kg in HED dose x 4? ~300mg?
From: http://www.ncbi.nlm....les/PMC4690535/
Supported by:
http://diabetes.diab...5-1127.abstract (Harvard)
http://www.ncbi.nlm....pubmed/26496802 (Yet another study validating it)
While a large number of hormones, small molecules, growth factors and nutrients are capable of inducing primary rodent β-cell replication, only harmine has been demonstrated to stimulate an increase in proliferation of adult primary human β-cells17,18.
Edited by Logjam, 10 May 2016 - 09:12 PM.
