• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Emotional blunting, dullness, detachment, anhedonia, apathy - help urgently needed

emotional detachment emotional dullness blunting

  • Please log in to reply
52 replies to this topic

#31 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 23 January 2017 - 04:06 PM

There's a new antipsychotic that seems to be more effective than others at treating negative symptoms, btw. It's called cariprazine.

sounds goood thanks!

 

Venlaflaxine=Effexor = SNRI

Abilify=Atypical antipsychotic,, common augmentation agent to antidepressants

Ciplralex=Lexapro = SSRI (a very selective one)

Gladem=Zoloft= SSRI(with some dopamine activity)

Deanxit = An old school antipsychotic and a tricyclic antidepressant

Pregabalin = Lyrica = a Gabapentinoid

Paroxat = Paxil = an SSRI

Tritico = Trazodone = an atypical antidepressant

 

In my experience anyway, SSRIs and SNRIs produce emotional blunting and anhedonia. And they are notorious for producing sexual side effects like loss of drive, delayed orgasm, etc. 

 

Since Welbutrin is not an SSRI it seems a logical choice. Also low dose lithium ~ 300-600 mg can turn up the volume on the medications you are taking. It's not a high enough dose usually to produce mood stabilization so that may or may not be good. And Lamictal is a mood stabilizer with antidepressant properties that is pretty much side effect free except for the fact that you have to go up very slowly on the dosage and stop immediately if you get a rash. Doctors usually hand out starter packs that taper you up from 25-200 mg over the course of several weeks. Neither of these options should have an impact on your sexual functioning.

 

Your response to nicotine+NAC and also to alcohol the day after are intriguing. There is a clue there. 

 

Substances in tobacco other than nicotine are monoamine oxidase inhibitors (MAOI). So despite the health impact, some sort of tobacco use is probably helpful. Vaping or nicotine gum probably would not have the same effect. OR you could go with a traditional MAOI. Many doctors are  reluctant to prescribe them because of dietary restrictions and drug interactions. But Moclobemide(Manerix) is a safe reversible MAOI that may be available in your country. Along with NAC. Given your response to tobacco and NAC this is where I'd lay my money.

 

The binding and metabolism of Alcohol is complex so it's difficult to say why you had the day after response to a binge. Rather than pregabalin which hits voltage dependent Calcium channels, a  drug more pharmaceutically related to alcohol like Valium might be worth a shot.Personally I'd resist attempts by doctors to give you a short acting high potency drug like Klonopin, Ativan, or Xanax. These cause heartache in the end whereas Valium is a relatively straightforward detox, should that need arise. And some people do experience euphoria from benzodiazepines. I don't, but it can happen.

 

PS All these medications can interact with recreational drugs in unpredictable ways.

first i wanted 2 say thanks a lot for your time and patience writing to me about my problem , really thank you, its a honor to me   :)

 

 

hmm interesting, i had a rash 7 weeks ago when i was on pregabalin (lyrica), but i continued.. what does that mean ?? if i havent stopped immediately?

 

so wellbutrin wouldnt be bad? u think wellbutrin as a  standalone medication wiithout any other medications except lithium as u said, would maybe help?

 

i will ask about maoi  (Manerix)  :) , but i didnt quite understand, what kind of dietry restrictions and drug interactions do u mean?

 

but valium makes addictive so i probably will leave this one out then...

 

what about low dose naltrxone, memantine ....?

 

and u think stuff like curcumin, rhodiola, inositol .. kinda nootropics are a waste of money??

 

 

and dont u think if i go back to nicotine for instance, that i could get the emotional blunting state away, since it will be difficult to say to which medications i will react positively since the dopamine feelings of nicotine distracts me the whole time?



#32 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 23 January 2017 - 04:15 PM

Overactive NMDA receptors are a cause for many mental illnesses. Before starting memantine I suffered from Apathy, anhedonia, OCD, ADHD, insomnia, Social anxiety, GAD and more. I started Memantine and after adjusting, my life did a 180. Then I added Moclobemide (depending where you are, it is prescribed or if in the US send me a pm) and it further aided my recovery. My life is completely different now. I suffer from none of the above, I am working as a personal trainer and as a manager of a restaurant, have a lovely girlfriend and finally have motivation to get up and go do things with my life. NA Selank Amidate and Fasoracetam also help with my anhedonia. Perhaps you can look into NSI-189 (PM me for source). I truly feel your pain and hope you start feeling better.

 

I would definitely look into memantine though, I started seeing major benefits at 30/40mg a day and when you get it in raw powder it is extremely cheap, especially through  https://nootropicsou...com/?ns=Jenden  since the link gives you 10% off automatically, I got a years supply for like 30 bucks  lol. I'm set. I have a lot of friends I told about memantine and they all agree it is one of the most life changing substances we've taken.

 

Tianeptine sulfate or sodium is a good choice as well. Memantine will also increase D2 receptors so you'll feel more will and drive.

 

hmm very interesting thanks :) and thx a lot ´trying to helpo me :)

 

i will definitely write this on my list, what about memantine prescribed from my doctor.. is that cleaner as the one to get on that website? or no differences?, did u suffer from emotional numbness?? how has that changed with memantine?

 

tianeptine : i have to get that one from my doc right? or are there any websites for that.... what kind of doctor does prescribe tianeptine. because my last psychiatric doc didnt deal with that one...

 

and stuff like curcumin which is somehow a nmda antagonist, is that a waste of money?



sponsored ad

  • Advert
Advertisements help to support the work of this non-profit organisation. To go ad-free join as a Member.

#33 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 23 January 2017 - 04:31 PM

Overactive NMDA receptors are a cause for many mental illnesses. Before starting memantine I suffered from Apathy, anhedonia, OCD, ADHD, insomnia, Social anxiety, GAD and more. I started Memantine and after adjusting, my life did a 180. Then I added Moclobemide (depending where you are, it is prescribed or if in the US send me a pm) and it further aided my recovery. My life is completely different now. I suffer from none of the above, I am working as a personal trainer and as a manager of a restaurant, have a lovely girlfriend and finally have motivation to get up and go do things with my life. NA Selank Amidate and Fasoracetam also help with my anhedonia. Perhaps you can look into NSI-189 (PM me for source). I truly feel your pain and hope you start feeling better.

 

I would definitely look into memantine though, I started seeing major benefits at 30/40mg a day and when you get it in raw powder it is extremely cheap, especially through  https://nootropicsou...com/?ns=Jenden  since the link gives you 10% off automatically, I got a years supply for like 30 bucks  lol. I'm set. I have a lot of friends I told about memantine and they all agree it is one of the most life changing substances we've taken.

 

Tianeptine sulfate or sodium is a good choice as well. Memantine will also increase D2 receptors so you'll feel more will and drive.

 

and how come someone can get memantine over the internet without prescribtion??

which one did u get ? :) powdder or liquid`?



#34 Neuronaut91

  • Guest
  • 15 posts
  • 4
  • Location:New York

Posted 23 January 2017 - 05:07 PM

I got memamtine prescribed after using ceretropics liquid because I found my script was $20 for the month compared to 80 for cerrtropics liquid. Are you in the US? It's legal to import or buy prescription drugs for research if domestically bought or for your own personal use if gotten from an overseas pharmacy. As long as it isn't a controlled substance.

I take curcumin but I take longvida or c3 for it's enhanced bioavailability. Didn't notice a difference in my ocd but definitely helped me with my anxiety in a weird way and pain. The only more natural-ish thing that really helped was NAC... For a while I tried to stick with herbs like ashwagandha, rhodiola, bacopa, but then I did a bit of research and wound up writing a thesis for a psych center on nmda receptors and their prevelance in mental health
Liquid memantine is good for when you're slowly titrating to the maintenance dose to try and counter any brain fog it may cause in the beginning
  • Agree x 1

#35 Mind_Paralysis

  • Guest
  • 1,715 posts
  • 155
  • Location:Scandinavia
  • NO

Posted 23 January 2017 - 07:16 PM

I got memamtine prescribed after using ceretropics liquid because I found my script was $20 for the month compared to 80 for cerrtropics liquid. Are you in the US? It's legal to import or buy prescription drugs for research if domestically bought or for your own personal use if gotten from an overseas pharmacy. As long as it isn't a controlled substance.

I take curcumin but I take longvida or c3 for it's enhanced bioavailability. Didn't notice a difference in my ocd but definitely helped me with my anxiety in a weird way and pain. The only more natural-ish thing that really helped was NAC... For a while I tried to stick with herbs like ashwagandha, rhodiola, bacopa, but then I did a bit of research and wound up writing a thesis for a psych center on nmda receptors and their prevelance in mental health
Liquid memantine is good for when you're slowly titrating to the maintenance dose to try and counter any brain fog it may cause in the beginning

 

I must say - that was rather clever, using liquid Memantine.

 

So many people try Memantine and get massive, massive brain-fog, that they rarely give the drug a proper chance - your method cuts out a lot of those problems.

 

 

Not sure if I'd be able to follow it myself though - burnout and SCT makes sticking to making, preparing and so forth, a liquid water(?) suspension of drugs damn-near impossible.

 

I'd have to be poppin' a combo of KHAT and Tianeptine to be able to do that, methinks!
 



#36 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 23 January 2017 - 08:09 PM

I got memamtine prescribed after using ceretropics liquid because I found my script was $20 for the month compared to 80 for cerrtropics liquid. Are you in the US? It's legal to import or buy prescription drugs for research if domestically bought or for your own personal use if gotten from an overseas pharmacy. As long as it isn't a controlled substance.

I take curcumin but I take longvida or c3 for it's enhanced bioavailability. Didn't notice a difference in my ocd but definitely helped me with my anxiety in a weird way and pain. The only more natural-ish thing that really helped was NAC... For a while I tried to stick with herbs like ashwagandha, rhodiola, bacopa, but then I did a bit of research and wound up writing a thesis for a psych center on nmda receptors and their prevelance in mental health
Liquid memantine is good for when you're slowly titrating to the maintenance dose to try and counter any brain fog it may cause in the beginning

 

nope im in austria..

 

hmm which brand did u use for the nac, curcumin ?

 

and why did u stop sticking with herbs? i didnt get it sorry?

 

hmm have u got any dosage plan for me for memantine pls :)  and how much nac do u take and how long did it take for your to notice benefits for ocb  from it??

 

and tianeptine ill have to get from a doctor i suppose?

 


Edited by ThreeKings12341, 23 January 2017 - 08:10 PM.


#37 Mind_Paralysis

  • Guest
  • 1,715 posts
  • 155
  • Location:Scandinavia
  • NO

Posted 05 February 2017 - 08:57 AM

Have you tried Lamotrigine yet? Or Cariprazine? Or Aripiprazole at a higher dose?

 

Stick with those first - they should be your first stop for these issues.

Might want to consider Reboxetine as an adjunct as well, btw - it's been shown to help with the negative symptoms of Schizophrenia.

 

Have you brought up your suspicion of a Schizoid-type disease to your Dr. btw? Because you did seem to respond fairly well to the idea recently, and if so, you definitely need to get that checked out and evaluated.


Edited by Stinkorninjor, 05 February 2017 - 08:58 AM.


#38 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 05 February 2017 - 10:46 AM

Have you tried Lamotrigine yet? Or Cariprazine? Or Aripiprazole at a higher dose?

 

Stick with those first - they should be your first stop for these issues.

Might want to consider Reboxetine as an adjunct as well, btw - it's been shown to help with the negative symptoms of Schizophrenia.

 

Have you brought up your suspicion of a Schizoid-type disease to your Dr. btw? Because you did seem to respond fairly well to the idea recently, and if so, you definitely need to get that checked out and evaluated.

 

ive talked about it , but i really wanted to get tianeptine prescribed.. which i take for 10 days now´.

 

next stop are those u mentioned.

 

hmm well i have spoken about it but she said i dont have that .or she didnt take it serious.. but im gona do a test on that now that u remineded me..



#39 Londonscouser

  • Guest
  • 94 posts
  • 3
  • Location:London
  • NO

Posted 05 February 2017 - 11:08 AM

I'm not a medical professional but I very much doubt that the OP has schizoid personality disorder

 

Yeah he may have symptoms that a person with schizoid would exhibit, but from what I've read about these individuals, one thing they avoid at all costs is an intimate relationship, which the OP does have and wants to have



#40 Mind_Paralysis

  • Guest
  • 1,715 posts
  • 155
  • Location:Scandinavia
  • NO

Posted 05 February 2017 - 11:36 AM

I'm not a medical professional but I very much doubt that the OP has schizoid personality disorder

 

Yeah he may have symptoms that a person with schizoid would exhibit, but from what I've read about these individuals, one thing they avoid at all costs is an intimate relationship, which the OP does have and wants to have

 

Perhaps not, I'll be the first to admit that he's very difficult to diagnose, to understand what the causes of these abnormal behaviours are.

 

I don't think he fits the typical profile of either Schizoid Personality Disorder or Schizotypal Personality Disorder, but he is too similar to various *different* Schizoidal disorders that I can't but help think he's somewhere on the Schizophrenic Spectrum.

 

What's your take on both the idea of a "Schizophrenic Spectrum" and the OP of this thread?

 

How would you categorize him? By reading his personal information, and the big post we made regarding his response to various psychopharmacology.

 

 

He's obviously NOT just depressed, there's something else going on.



#41 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 05 February 2017 - 12:04 PM

hmmm let me write more maybe it helps:

 

i have adrenal fatique syndrome my dhea levels are very low in the evening and my cortisol also, i had thyroid over function or still have a hidden one..  ( i never have taken dhea or pregnenolone kinda stuff)

 

i think the emotional blunting thing might come from epstein bar virus in combination with a lot of crying because of developing bodydymophobic disorder. but maybe it comes from the weed and the ssris i dont know.. i hope ill get better :/

 

i feel like constantly kinda no emotion but there is no hole kinda feeling in my stomach or something, like i would call it empty positive permantly kinda state is what i have since i have won the battle against the bodydysmophobic disorder  (the time when i smoked nicotine and took n-acetylcystein - (2016 february)...


Edited by ThreeKings12341, 05 February 2017 - 12:06 PM.


#42 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 05 February 2017 - 12:11 PM

also, when i listen to music, i get nearly 90 % of every time listening, an euphoric kinda state or like im on weed. music always felt fanstastic to me or listened fantastic. i love listening to drum and bass and it makes my body move nearly  everytime, but i wouldnt call it a clear emotion, but its  a high kinda state or euphoric or happy i dont know...



#43 PeaceAndProsperity

  • Guest
  • 1,194 posts
  • -195
  • Location:Heaven

Posted 05 February 2017 - 01:22 PM

I swear to God Almighty, everytime I read a post about some cognitive issue or affective issue on a forum, it's always coincidentally mentioned later on that the OP just so happens to use cannabis and other drugs once in a while. Gee, it's like there might be a correlation between the use of brain-damaging chemicals and issues experienced by the user. But I don't know, it's difficult to tell exactly.


  • Agree x 3
  • Unfriendly x 1
  • dislike x 1

#44 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 07 February 2017 - 09:27 PM

I swear to God Almighty, everytime I read a post about some cognitive issue or affective issue on a forum, it's always coincidentally mentioned later on that the OP just so happens to use cannabis and other drugs once in a while. Gee, it's like there might be a correlation between the use of brain-damaging chemicals and issues experienced by the user. But I don't know, it's difficult to tell exactly.

 

i get that, but i think in my case it all started before smoking weed ( i think 99 %).  weed feels fuckin great for me, but thats the last root im gona hit , if nothing will work. im gona give myself 4 more years of soberness. tomorrow already 9 months abstinent of alcohol :D and 12 months no smoking.



#45 jaiho

  • Guest
  • 521 posts
  • 12
  • Location:Motherland
  • NO

Posted 07 February 2017 - 11:19 PM

It's depression.

People just dont seem to get what depression is. It isn't being sad. It is a complete disconnection to your emotions, your soul/heart.

It kills your feelings, produces anhedonia, emotional blunting.

 

SSRIs can also cause this but it can also resolve it, if its the right SSRI for your neurochemistry.

Some people need augmentation strategies. 

Here's a good algorithm for treating it.

http://psychotropica...al-ad-algorithm



#46 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 07 February 2017 - 11:37 PM

It's depression.

People just dont seem to get what depression is. It isn't being sad. It is a complete disconnection to your emotions, your soul/heart.

It kills your feelings, produces anhedonia, emotional blunting.

 

SSRIs can also cause this but it can also resolve it, if its the right SSRI for your neurochemistry.

Some people need augmentation strategies. 

Here's a good algorithm for treating it.

http://psychotropica...al-ad-algorithm

 

 i know that :) thx for the link. looks interesting!

 

since u know so much about this jaiho.. what do u think in my case except nsi , u would recommend me.. u think ssris really could heal it? and not produce even a worse zombie state?,

abstinence of drugs may work u think?

the right diet?

 

and did nsi-189 work for you  also or ONLY with the psilocybin stuff - for emotions?


Edited by ThreeKings12341, 07 February 2017 - 11:40 PM.


#47 jaiho

  • Guest
  • 521 posts
  • 12
  • Location:Motherland
  • NO

Posted 08 February 2017 - 12:38 AM

NSI-189 + Moclobemide worked for me, and occasional LSD/Psilocybin.

Theres many ways to go about it. 

You can also do the SSRI + TCA combination.


  • Agree x 1

#48 PeaceAndProsperity

  • Guest
  • 1,194 posts
  • -195
  • Location:Heaven

Posted 08 February 2017 - 02:07 AM

Theanine helps (i.e. 20% more emotions) for me but I find it often takes a few days, and low dosages like 50mg (I eyeball it).



#49 stan08

  • Guest
  • 175 posts
  • 2
  • Location:USA
  • NO

Posted 08 February 2017 - 11:43 AM

NSI-189 + Moclobemide worked for me, and occasional LSD/Psilocybin.
Theres many ways to go about it.
You can also do the SSRI + TCA combination.


What about sertraline and tianeptine as a ssri + tca combo?

#50 sentics

  • Guest
  • 78 posts
  • 6
  • Location:Vienna
  • NO

Posted 08 February 2017 - 12:34 PM

NSI-189 + Moclobemide worked for me, and occasional LSD/Psilocybin.

Theres many ways to go about it. 

You can also do the SSRI + TCA combination.

 

what made you stop nsi + moclobemide?

 

I've had some success with nsi + low dose sertraline + relora and I'm about to go on a trial of St. John's Wort + NSI, since I've had success with SJW many years ago in regards of insomnia, anhedonia and low libido. I think the NSI might give it a nice boost.



#51 Mind_Paralysis

  • Guest
  • 1,715 posts
  • 155
  • Location:Scandinavia
  • NO

Posted 08 February 2017 - 01:14 PM

 

NSI-189 + Moclobemide worked for me, and occasional LSD/Psilocybin.

Theres many ways to go about it. 

You can also do the SSRI + TCA combination.

 

what made you stop nsi + moclobemide?

 

I've had some success with nsi + low dose sertraline + relora and I'm about to go on a trial of St. John's Wort + NSI, since I've had success with SJW many years ago in regards of insomnia, anhedonia and low libido. I think the NSI might give it a nice boost.

 

 

That's NOT a good idea!

 

SJW is infamous for its interference with the effects of other compounds - it really messes with tons and tons of enzymes - don't forget that we still don't know how NSI-189 metabolizes - remember, the therapeutic index of NSI-189 is a bell-shaped curve - if you start going past 80 mg per day, then eventually you will hit a dead-end which means NSI-189 will actually STOP working!

 

Around 120 mg is where it stops - and what if SJW increases the plasma-levels of NSI-189? You could then, unknowingly, all of a sudden, be using 130 mg, even though you're only dosing it worth of 20 mg.

 

It could also cause NSI-189 levels to drop too low - perhaps you'd only be getting 10 mg, even though you'd be dosing 20 mg - that would also lead to insufficient effect.

 

 

I say, wait with using this combo, until Neuralstem presents more data on the compound - you can always go for combining SJW with something else, which you have reacted good to in the past.

 

Maybe...

 

SJW + Relora?

SJW + Tianeptine?

 

 

I don't know, SJW is tricky to combine with stuff.
 



#52 sentics

  • Guest
  • 78 posts
  • 6
  • Location:Vienna
  • NO

Posted 09 February 2017 - 10:21 AM

Maybe...

 

SJW + Relora?

SJW + Tianeptine?

 

 

I don't know, SJW is tricky to combine with stuff.
 

 

 

thanks, i appreciate your input and concern. i have combined nsi-189 with a couple of other substances like lamotrigine without "a problem" whatever that means.

 

I'm aware though that SJW hits a lot of stuff and i will tread carefully and titrate SJW up to a therapeutic dose before tentatively adding a low dose of nsi.


  • like x 1

sponsored ad

  • Advert
Advertisements help to support the work of this non-profit organisation. To go ad-free join as a Member.

#53 ThreeKings12341

  • Topic Starter
  • Guest
  • 169 posts
  • 0
  • Location:Berlin

Posted 11 April 2017 - 07:22 PM

 

Maybe...

 

SJW + Relora?

SJW + Tianeptine?

 

 

I don't know, SJW is tricky to combine with stuff.
 

 

 

thanks, i appreciate your input and concern. i have combined nsi-189 with a couple of other substances like lamotrigine without "a problem" whatever that means.

 

I'm aware though that SJW hits a lot of stuff and i will tread carefully and titrate SJW up to a therapeutic dose before tentatively adding a low dose of nsi.

 

hey sentics. wrote u pm since i realised that we live in the same city. and also have the same issues as i discovered...

 

ps im not from berlin ;)


Edited by ThreeKings12341, 11 April 2017 - 07:22 PM.






Also tagged with one or more of these keywords: emotional detachment, emotional dullness, blunting

2 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users


    Bing (1)