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Resveratrol in obese mice show alterations in gut microbiome

resveratrol mice microbiome

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#1 malbecman

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Posted 05 December 2016 - 04:47 PM

 All roads do perhaps lead to the gut microbiome: 



Improved Glucose Homeostasis in Obese Mice Treated with Resveratrol is Associated with Alterations in the Gut Microbiome
Miranda M. SungTy T. KimEmmanuel DenouCarrie-Lynn M. SoltysShereen M. HamzaNikole J.ByrneGrant MassonHeekuk ParkDavid S. WishartKaren L. MadsenJonathan D. SchertzerJason R. B.Dyck


Diabetes 2016 Nov; db160680. http://dx.doi.org/10.2337/db16-0680

Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and increased relative abundance of Bacteroides and Parabacteroides. Moreover, fecal transfer from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.

#2 Geoffrey

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Posted 11 December 2016 - 08:08 PM

Very interesting, and concords with the other study posted by Anthony Loera (currently below this one). What if the effect of resveratrol was all along mediated via gut microbiome? Could this account for the effect produced by resveratrol in wine? Might the synergy with alcohol increase its effects on modifying or controlling the biome in the gut? With the recent news that Parkinson's seems to be mediated by gut microbiome, perhaps this effect generally is much greater than we've known to date.

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